Results from univariate and multivariate analysis of ALS patients compared to controls.

<p>Results from univariate and multivariate analysis of ALS patients compared to controls.</p

ALS Biomarker candidates.

<p>Boxplots showing the CSF levels for follistatin, IL1-alpha and KLK5 for ALS patients and matched controls. The protein levels are compared using the Mann-Whitney U-test and p-values are displayed in the Figures. The limits of detection are indicated by dashed horizontal lines. The y-axes represent Ct-values.</p

Protein variation among the investigated individuals.

<p><b>A) Boxplots showing protein concentrations ranges in CSF from 72 individuals without neurological disorders.</b> The concentration ranges between the upper and lower limits of detection for each marker are shown in grey. The numbers below and above the boxplots show the number of patient samples (out of the total 72) that are outside the detection limits. <b>B) Performance measures for each protein assay.</b> The 1^st, 2^nd (median) and 3^rd quartile values of the robust % CV. The numbers of detectable samples out of a total of 72 samples are found at the bottom line for each marker.</p