10 research outputs found

    Thrombosis in vasculitis: from pathogenesis to treatment

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    In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected. Inflammation-induced thrombosis is by now considered a feature not only of autoimmune rheumatic diseases, but also of systemic vasculitides such as Behçet’s syndrome, ANCA-associated vasculitis or giant cells arteritis, especially during active disease. These findings have important consequences in terms of management and treatment. Indeed, Behçet’syndrome requires immunosuppressive agents for vascular involvement rather than anticoagulation or antiplatelet therapy, and it is conceivable that also in ANCA-associated vasculitis or large vessel-vasculitis an aggressive anti-inflammatory treatment during active disease could reduce the risk of thrombotic events in early stages. In this review we discuss thrombosis in vasculitides, especially in Behçet’s syndrome, ANCA-associated vasculitis and large-vessel vasculitis, and provide pathogenetic and clinical clues for the different specialists involved in the care of these patients

    Sea level variability at Antalya and Mentes tide gauges in Turkey: atmospheric, steric and land motion contributions

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    Sea level trends and interannual variability at Antalya and Mentes tide gauges are investigated during the 1985-2001 period, quantifying the roles of atmospheric, steric and local land motion contributions. Tide gauge sea level measurements, temperature/salinity climatologies and GPS data are used in the analyses and the results are compared with the output of a barotropic model forced by atmospheric pressure and wind. The overall sea level trends at two tide gauges collocated with GPS are in the range of 5.5 to 7.9 mm/yr during the study period, but showing different behaviour in the sub-periods 1985-1993 and 1993-2001 due to variations in the contributing factors both in space and time. After the removal of the atmospheric forcing and steric contribution from sea level records, the resulting trends vary between 1.9 to 4.5 mm/yr in Antalya and -1.2 to -11.6 mm/yr in Mentes depending on the period considered. Vertical land movement estimated from GPS data seems to explain the high positive residual trend in Antalya during the whole period. On the other hand, the source of the highly negative sea level trend of about -14 mm/yr in Mentes during 1985-1993 could not be resolved with the available datasets. Interannual variability of wind and atmospheric pressure appear to dominate the sea level at both tide gauges during the study period. Atmospheric and steric contributions together account for similar to 50% of the total sea level variance at interannual time scales. Mass induced sect level variations which were not considered in this study may help to close the sea level trend budgets as well as to better explain the interannual sett level variance

    from GPS and InSAR Data

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    Düzce earthquake ruptured a ca. 40-km-long adjoining strand of the North Anatolian fault (NAF) system to the east. We used displacements of 50 Global Positioning System (GPS) sites together with interferometric synthetic aperture radar (InSAR) range-change data spanning the event to estimate the geometry and slip distribution of the coseismic rupture. Postseismic deformation transients from the Düzce earthquake and the preceding I˙zmit event that are included in some of the measurements are corrected for using dislocation models fit to GPS data spanning the various time periods. Nonlinear inversions for fault geometry indicate that the rupture occurred on a ca. 54 � north-dipping oblique normal, right-lateral fault. Distributed-slip inversions indicate maximum strike slip near the center of the Düzce fault close to the earthquake hypocenter. Slip magnitude and depth of faulting decrease to the west and east of the hypocenter. Both GPS and InSAR data suggest that normal slip is restricted to the shallow portion of the rupture. The Düzce earthquake had the highest slip-to-rupture-length ratio of any historic earthquake along the NAF

    Fabrication of optical nanodevices through field-emission scanning probe lithography and cryogenic etching

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    Sub-10 nanometer lithography is opening a new area for beyond-CMOS devices. Regarding to single nano-digit manufacturing we have established a new maskless patterning scheme by using field-emission, current controlled Scanning Probe Lithography (cc-SPL) in order to create optical nanodevices in thin silicon-on-insulator (SOI) substrates. This work aims to manufacture split ring resonators into calixarene resist by using SPL, while plasma etching at cryogenic temperatures is applied for an efficient pattern transfer into the underlying Si layer. Such electromagnetic resonators take the form of a ring with a narrow gap, whose 2D array was the first left-handed material tailored to demonstrate the so-called left-hand behavior of the wave propagation. It is shown that the resonance frequency can be tuned with the feature size of the resonator, and the resonance frequency can be shifted further into near infrared or even visible light regions
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