1 research outputs found
Friedel–Crafts Alkylation of Acylphloroglucinols Catalyzed by a Fungal Indole Prenyltransferase
Naturally
occurring prenylated acylphloroglucinol derivatives are plant metabolites
with diverse biological and pharmacological activities. Prenylation
of acylphloroglucinols plays an important role in the formation of
these intriguing natural products and is catalyzed in plants by membrane-bound
enzymes. In this study, we demonstrate the prenylation of such compounds
by a soluble fungal prenyltransferase AnaPT involved in the biosynthesis
of prenylated indole alkaloids. The observed activities of AnaPT toward
these substrates are much higher than that of a microsomal fraction
containing an overproduced prenyltransferase from the plant hop