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Investigations on the Structure Tectonics, Geophysics, Geochemistry, and Hydrocarbon Potential of the Black Mesa Basin, Northeastern Arizona
The U.S. Department of Energy (DOE) has instituted a basin-analysis study program to encourage drilling in underexplored and unexplored areas and increase discovery rates for hydrocarbons by independent oil companies within the continental United States. The work is being performed at the DOE's National Institute for Petroleum and Energy Research (NIPER) in Bartlesville, Oklahoma, by the Exploration and Drilling Group within BDM-Oklahoma (BDM), the manager of the facility for DOE. Several low-activity areas in the Mid-Continent, west, and southwest were considered for the initial study area (Reeves and Carroll 1994a). The Black Mesa region in northwestern Arizona is shown on the U.S. Geological Survey 1995 oil and gas map of the United States as an undrilled area, adapted from Takahashi and Gautier 1995. This basin was selected by DOE s the site for the initial NIPER-BDM survey to develop prospects within the Lower-48 states (Reeves and Carroll 1994b)
Functional Near-Infrared Spectroscopy Reveals Reduced Interhemispheric Cortical Communication after Pediatric Concussion
Cerebral Perfusion Changes in Post-Concussion Syndrome: A Prospective Controlled Cohort Study
Repetitive Mild Traumatic Brain Injuries in Mice during Adolescence Cause Sexually Dimorphic Behavioral Deficits and Neuroinflammatory Dynamics
Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions successfully translated to the clinic. Increased importance on the progressive, long-term consequences of TBI have been emphasized, both in the experimental and clinical literature. Thus, there is a need for a better understanding of the chronic consequences of TBI, with the ultimate goal of developing novel therapeutic interventions to treat the devastating consequences of brain injury. In models of mild, moderate, and severe TBI, histopathological and behavioral studies have emphasized the progressive nature of the initial traumatic insult and the involvement of multiple pathophysiological mechanisms, including sustained injury cascades leading to prolonged motor and cognitive deficits. Recently, the increased incidence in age-dependent neurodegenerative diseases in this patient population has also been emphasized. Pathomechanisms felt to be active in the acute and long-term consequences of TBI include excitotoxicity, apoptosis, inflammatory events, seizures, demyelination, white matter pathology, as well as decreased neurogenesis. The current article will review many of these pathophysiological mechanisms that may be important targets for limiting the chronic consequences of TBI