58 research outputs found
Duration of wrinkle correction following repeat treatment with Juvéderm hyaluronic acid fillers
Many patients elect to have repeat treatments with hyaluronic acid dermal fillers to maintain wrinkle correction, but the clinical performance of these products after repeat treatments has not been formally assessed. The primary objective of this study was to evaluate the effectiveness of JuvĂ©derm injectable gel (JuvĂ©derm Ultra, JuvĂ©derm Ultra Plus, and JuvĂ©derm 30) through 1 year after repeat treatment of nasolabial folds (NLFs) that were previously treated with JuvĂ©derm or Zyplast 6â9 months prior to the repeat treatment. Upon completion of the pivotal IDE clinical trial for JuvĂ©derm, five of the original 11 study sites were selected to participate in an extended follow-up evaluation, and a total of 80 subjects were enrolled. For the JuvĂ©derm-treated NLFs in each treatment group, the median injection volume was 1.5â1.6 mL for initial treatment but only 0.5â0.6 mL for the repeat treatment (p < 0.0001). Mean Investigator-assigned NLF severity scores on a scale of 0â4 for the JuvĂ©derm-treated NLFs improved from 2.5â2.7 (moderate to severe) at baseline to 1.2â1.5 (mild) just prior to repeat treatment (>24 weeks) and 0.7â0.9 (mild) at 4 weeks after repeat treatment. At 48 weeks post-repeat treatment, the mean NLF scores were 1.1â1.3 (mild), and 78â90% of subjects were considered responders (â„1 point improvement). Thus, subjects sustained a total of 18â21 months of wrinkle correction with a repeat treatment at 6â9 months and needed substantially less filler (60% less) for repeat treatment than for initial treatment, indicating that retreatment at this timepoint may be beneficial to patients
Bone defects following curettage do not necessarily need augmentation: A retrospective study of 146 patients
Background and purpose The natural pattern of bone healing in large bony defects following curettage alone as treatment of benign bone tumors around the knee is not well reported. We analyzed the outcome in 146 patients
Human Histology and Persistence of Various Injectable Filler Substances for Soft Tissue Augmentation
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