Proof of the deadlock-freeness of ALD routing algorithm

This is the appendix to the paper Load-Balanced Adaptive Routing for Torus Networks to provide a detailed, formal proof of the deadlock-freeness of the routing algorithm proposed in the paper. The paper is submitted to Electronics Letters, and the abstract of which is as follows: A new routing algorithm for torus interconnection networks to achieve high throughput on various traffic patterns, Adaptive Load-balanced routing with cycle Detection (ALD), is presented. Instead of the -channels scheme adopted in a few recently proposed algorithms of the same category, a cycle detection scheme is employed in ALD to handle deadlock, which leads to higher routing adaptability. Simulation results demonstrate that ALD achieves higher throughput than the recently proposed algorithms on both benign and adversarial traffic patterns

A Submodular Optimization Framework for Outage-Aware Cell Association in Heterogeneous Cellular Networks

In cellular heterogeneous networks (HetNets), offloading users to small cell base stations (SBSs) leads to a degradation in signal to interference plus noise ratio (SINR) and results in high outage probabilities for offloaded users. In this paper, we propose a novel framework to solve the cell association problem with the intention of improving user outage performance while achieving load balancing across different tiers of BSs. We formulate a combinatorial utility maximization problem with weighted BS loads that achieves proportional fairness among users and also takes into account user outage performance. A formulation of the weighting parameters is proposed to discourage assigning users to BSs with high outage probabilities. In addition, we show that the combinatorial optimization problem can be reformulated as a monotone submodular maximization problem and it can be readily solved via a greedy algorithm with lazy evaluations. The obtained solution offers a constant performance guarantee to the cell association problem. Simulation results show that our proposed approach leads to over 30% reduction in outage probabilities for offloaded users and achieves load balancing across macrocell and small cell BSs

High density lipoprotein promotes proliferation of adipose-derived stem cells via S1P1 receptor and Akt, ERK1/2 signal pathways

Introduction: Adipose-derived stem cells (ADSC) are non-hematopoietic mesenchymal stem cells that have shown great promise in their ability to differentiate into multiple cell lineages. Their ubiquitous nature and the ease of harvesting have attracted the attention of many researchers, and they pose as an ideal candidate for applications in regenerative medicine. Several reports have demonstrated that transplanting ADSC can promote repair of injured tissue and angiogenesis in animal models. Survival of these cells after transplant remains a key limiting factor for the success of ADSC transplantation. Circulating factors like High Density Lipoprotein (HDL) has been known to promote survival of other stems cells like bone marrow derived stem cells and endothelial progenitor cells, both by proliferation and by inhibiting cell apoptosis. The effect of HDL on transplanted adipose-derived stem cells in vivo is largely unknown. Methods: This study focused on exploring the effects of plasma HDL on ADSC and delineating the mechanisms involved in their proliferation after entering the bloodstream. Using the MTT and BrdU assays, we tested the effects of HDL on ADSC proliferation. We probed the downstream intracellular Akt and ERK1/2 signaling pathways and expression of cyclin proteins in ADSC using western blot. Results: Our study found that HDL promotes proliferation of ADSC, by binding to sphingosine-1-phosphate receptor-1(S1P1) on the cell membrane. This interaction led to activation of intracellular Akt and ERK1/2 signaling pathways, resulting in increased expression of cyclin D1 and cyclin E, and simultaneous reduction in expression of cyclin-dependent kinase inhibitors p21 and p27, therefore promoting cell cycle progression and cell proliferation. Conclusions: These studies raise the possibility that HDL may be a physiologic regulator of stem cells and increasing HDL concentrations may be valuable strategy to promote ADSC transplantation.'973' National ST Major Project [2011CB503900]; National Natural Science Foundation of China [81270321, 81170101, 81370235]; Natural Science Foundation of Beijing, China [7122106]SCI(E)[email protected]; [email protected]

Brief Communication Relationship of high CH50 level and interruption of cascade reaction of complement mRNA expression in acute venous thromboembolism patients

Abstract: In patients with pulmonary embolism (PE), forepart components of complements were activated. However there are interruption/decrease of cascade reaction and cytolytic effects in complement system. This study detected CRP, CH50, C3 and C4 levels in patients with venous thromboembolism (VTE) and compare with the imbalance of complement associated gene mRNA expression in PE patients. There was significant increase of CH50 in acute VTE patients. Even though CH50 increased significantly in acute VTE patients and had a relatively high sensitivity, cytolytic effects of complements might decrease, based on the genomics results of complement cascade reactions imbalance/interruption and increased total complements in VTE patients