21 research outputs found
Captain John Smith: American (?)
- Author
- Publication venue
- eGrove
- Publication date
- 01/01/1984
- Field of study
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
- Andrews L
- Andrews R
- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
- Archer A
- Armitage J
- Armstrong L
- Armstrong M
- Arnesson K
- Arnold M
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- Arp H
- Asbill B
- Ashbrook-raby C
- Ashton L
- Assarsson E
- Audet K
- Augenbraun C
- Aung HNIN THANDA
- Auscher S
- Ausner J
- Aviles R
- Awasty V
- Axelsson U
- Ayers S
- Ayub H
- Babar G
- Babington G
- Backlund M
- Badal B
- Baggiore C
- Baghiana S
- Bai H
- Bai J
- Baigent C
- Baillargeon G
- Bakbak A
- Baker S
- Baldin Mg
- Baldini E
- Baldwin E
- Ballantyne C
- Baltic A
- Banerjee S
- Bang Hansen M
- Banks K
- Bansilal S
- Barkley-daughtry S
- Barnes D
- Barnes E
- Barnett S
- Baroni Claudio
- Barry S
- Barter P
- Bartolomei Mecatti B
- Barton I
- Barton J
- Baré C
- Bashton D
- Basler M
- Bastani L
- Basvi P
- Batchlett K
- Bateman S
- Battistelli E
- Baty J
- Bauersachs J
- Bauman A
- Bavendiek U
- Baxter A
- Bayly G
- Bays H
- Beasley T
- Beck P
- Beck S
- Becker P
- Beebe S
- Been M
- Begg R
- Behm K
- Beilker J
- BeiĂner S
- Bekfani T
- Belanger B
- Belew K
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- Bellamy C
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- Betzl G
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- Bhargava R
- Bhatia
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- Bjergo J
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- CARIDAD HERNANDEZ JOSE MANUEL
- Carlos S
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- Casey MAEVE ANN
- Casey MAEVE ANN
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- Childs A
- Chiodi Riccardo
- Chirio C
- Chmilewski S
- Christensen A
- Christensen B
- Christensen S
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- Chun-furlong D
- Chung K
- Chung R
- Ciampanelli E
- Ciuica S
- Clark A
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- Claxton E. Jr
- Clayton-evans L
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- Crivellari ADAM MARIA ROMANO
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- Danish Rizvi M
- Darlington H
- Darrel-asherel E
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- Davies M
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- Dawe C
- Dawkins Hughes S
- Dayanandan R
- De Boer I
- De Burca B
- De Donno O
- De La Garza J
- De Lorenzi E
- De Matteis C
- De Servi S
- De Silva R
- Dechert M
- Defosse C
- Defraia C
- Del Mastro E
- Dela Cruz C
- Delgado T
- Delozier A
- Delucca P
- Demets D
- Deng X
- Dengler T
- Desai N
- Desai V
- Desantis J
- Deslongchamp F
- Desousa C
- Destefano R
- Dettmer M
- Dhaliwal M
- Di Biase M
- DI BUONO Antonio
- Di Donato A
- Di Matteo C
- Di Pasquale G
- Di Ruocco M
- Diao Q
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- Dietrich D
- Diget H
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- Domingue N
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- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
- Zhu X
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- Ziefle S
- Zilz N
- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- à gÄrdh A
- Ăner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Epidemiology and etiology of Parkinsonâs disease: a review of the evidence
- Author
- A Alonso
- A Ascherio
- A Ascherio
- A Ascherio
- A Ascherio
- A Ascherio
- A Bajaj
- A Barbeau
- A Barbeau
- A Bergareche
- A Bocchetta
- A Di Fonzo
- A Di Fonzo
- A Di Fonzo
- A Diem-Zangerl
- A Elbaz
- A Elbaz
- A Elbaz
- A Elbaz
- A Elbaz
- A Elbaz
- A Elbaz
- A Elbaz
- A Elbaz
- A Elbaz
- A Grandinetti
- A Hofman
- A Hofman
- A Iranzo
- A Ishikawa
- A Korchounov
- A Kuopio
- A Laihinen
- A Lombard
- A McInerney-Leo
- A Menegon
- A Mitsumoto
- A Morano
- A Nicoletti
- A Nuti
- A Paganini-Hill
- A Polder
- A Priyadarshi
- A Ramirez
- A Seidler
- A Smargiassi
- A Vieregge
- A Zimprich
- AA Hicks
- AA Li
- AB Singleton
- AB West
- AB West
- AB West
- AF Leentjens
- AF Leentjens
- AG Schuurman
- AH Evans
- AH Rajput
- AH Rajput
- AH Rajput
- AJ Hughes
- AJ Hughes
- AJ Hughes
- AJ Hughes
- AJ Sasco
- AJ Sasco
- AJ Sasco
- AL DeStefano
- AL DeStefano
- AL McCormack
- AL Werneck
- AM Kuopio
- AM Kuopio
- AR Rosen
- AR Troiano
- AS Dhillon
- AS Najim al-Din
- B Jansson
- B Kandinov
- B Kandinov
- B Kis
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Men of Letters in Colonial Maryland
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- Newfound Press
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- 13/05/2015
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V. Name Index (with some biographical notes)
- Author
- Publication venue
- Publication date
- Field of study
The name index often adds brief biographical identification
On the Sources and Authorship of âA Letter From Father Abraham to His Beloved Sonâ
- Publication venue
- 'MIT Press - Journals'
- Publication date
- Field of study
Handling the Soviet threat: âProject controlâ and the debate on American strategy in the early Cold War years
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
European and American Political Architects: Prince Klemens Wenzel von Metternich, Lord Castlereagh, Benjamin Franklin What Did They Expect?
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Practical Approach to the Hormonal Treatment of Acne
- Author
- A Audebert
- A Burke
- A Lemay
- A Lemay
- American College of Obstetricians and gynecologists (ACOG) Committee on Practice Bulletins-Gynecology
- AW Lucky
- B Dreno
- B Runnenbaum
- BC Tanis
- C Charoenvisal
- C Farquhar
- D Deplewski
- D Raudrant
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- D Thiboutot
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- D Thiboutot
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- G Sansone
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- M Vartiainen
- O Lidegaard
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- PD Darney
- S Aydinlik
- S Maddin
- SM Slayden
- V Leo De
- V Moreno
- W Chen
- WA Vloten van
- WO Spitzer
- Yves Poulin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management
- Author
- A. Love
- A. Rane
- Alexandraki K
- Altuntas Y
- Azziz R
- Banaszewska B
- Ben-Haroush A
- Berneis K
- Borg P
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- Chapelot D
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- Dewan S
- Diamanti-Kandarakis E
- Diamanti-Kandarakis E
- Diamanti-Kandarakis E
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- Farnsworth E
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- Farshchi H
- Farshchi H
- Farshchi H R
- Filippatos T D
- Foster G D
- Gambineri A
- Gambineri A
- Gannon M C
- Glintborg D
- Glintborg D
- Glueck C J
- Glueck C J
- Glueck C J
- Goldenberg N
- Gonzalez F
- Goodarzi M O
- Gulcelik N E
- Gulseren L
- H. Farshchi
- Hahn S
- Hardiman P
- Harnack L
- Himelein M J
- Himelein M J
- Hoeger K M
- Jakicic J M
- Jayagopal V
- Jeffery R W
- Karabacak I YNI
- Kasim-Karakas S E
- Kennedy R L
- Kerver J M
- Kirchengast S
- Kwiterovich P O
- Layman D K
- Lemay A
- Levin B E
- Liu X H
- Lo J C
- Majuri A
- Marsh K
- Mastorakos G
- McAuley K A
- Merhi Z O
- Mitkov M
- Mor E
- Moran L J
- Moran L J
- Nader S
- Nordmann A J
- Norman R J
- Pasquali R
- Pelusi B
- Pi-Sunyer F X
- Poehlman E T
- R. L. Kennedy
- Rautio K
- Reimer R A
- Riccardi G
- Sabuncu T
- Salehi M
- Samaha F F
- Sartor B M
- Sharman M J
- Sjoberg A
- Smith S R
- Stamets K
- Stein K
- Stern L
- Tang T
- Topcu S
- Van Dam E WCM
- van Dam E WCM
- Van Gaal L F
- Vessby B
- Vessby B
- Vrbikova J
- Wang J X
- Westphal L M
- Wild R A
- Yildirim B
- Zhang Y F
- Publication venue
- Informa Healthcare
- Publication date
- 01/11/2007
- Field of study
PCOS patients are not always markedly overweight but PCOS is strongly associated with abdominal obesity and insulin resistance. Effective approaches to nutrition and exercise improve endocrine features, reproductive function and cardiometabolic risk profile - even without marked weight loss. Recent studies allow us to make recommendations on macronutrient intake. Fat should be restricted to â€30% of total calories with a low proportion of saturated fat. High intake of low GI carbohydrate contributes to dyslipidaemia and weight gain and also stimulates hunger and carbohydrate craving. Diet and exercise need to be tailored to the individual's needs and preferences. Calorie intake should be distributed between several meals per day with low intake from snacks and drinks. Use of drugs to either improve insulin sensitivity or to promote weight loss are justified as a short-term measure, and are most likely to be beneficial when used early in combination with diet and exercise