17 research outputs found
High modulus hydrogels for ophthalmic and related biomedical applications
This paper presents three families of semiâinterpenetrating polymer network (SIPN) hydrogels based on an esterâbased polyurethane (EBPU) and hydrophilic monomers: N,Nâdimethylacrylamide (NNDMA), Nâvinyl pyrrolidone (NVP) and acryloylmorpholine (AMO) as potential materials for keratoprosthesis, orthokeratology and miniâscleral lens application. Hydrogels sheets were synthesized via freeâradical polymerization with methods developed inâhouse. SIPN hydrogels were characterized for their equilibrium water content, mechanical and surface properties. Three families of optically clear SIPNâbased hydrogels have been synthesized in the presence of water with >10% of composition attributable to EBPU. Water contents of SIPN materials ranged from 30% to 70%. SIPNs with â€15% EBPU of total composition showed little influence to mechanical properties, whereas >15% EBPU contributed significantly to an increase in material stiffness. In the hydrated state, SIPNs with â€15% EBPU of total composition show little difference in polar component (Îłp) of surface free energy, whereas for >15% EBPU there is a decrease in Îłp. The EBPU SIPN hydrogels display complementary material properties for keratoprosthesis, orthokeratology, and miniâscleral applications