3 research outputs found
Surface-Independent Hierarchical Coatings with Superamphiphobic Properties
Facile approaches for the fabrication
of substrate independent superamphiphobic surfaces that can repel
both water and organic liquids have been limited. The design of such
super-repellent surfaces is still a major challenge of surface chemistry
and physics. Herein, we describe a simple and efficient dip-coating
approach for the fabrication of highly hierarchical surface coatings
with superamphiphobic properties for a broad range of materials based
on a mussel-inspired dendritic polymer (MI-dPG). The MI-dPG coating
process provides a precise roughness control, and the construction
of highly hierarchical structures was achieved either directly by
pH-controlled aggregation or in combination with nanoparticles (NP).
Moreover, the fabrication of coatings with a thickness and roughness
gradient was possible via simple adjustment of the depth of the coating
solution. Subsequent postmodification of these highly hierarchical
structures with fluorinated molecules yielded a surface with superamphiphobic
properties that successfully prevented the wetting of liquids with
a low surface tension down to about 30 mN/m. The generated superamphiphobic
coatings exhibit impressive repellency to water, surfactant containing
solutions, and biological liquids, such as human serum, and are flexible
on soft substrates
Selective Endothelial Cell Adhesion via Mussel-Inspired Hybrid Microfibrous Scaffold
Endothelialization
of the polymer substrate is limited by unspecific
cell adhesion. Herein, a biodegradable microfibrous scaffold with
a reversibly thermoswitchable property was developed to dynamically
regulate endothelial progenitor cell adhesion by exposing or concealing
cRGD motif to the surface with a thermosensitive moiety (cRGD-PNIPAM)
and antifouling moiety linear polyglycerol (LPG). Owing to a reversible
α<sub>v</sub>β<sub>3</sub> integrin–cRGD interaction
and ligand presentation, the accelerated endothelial cell adhesion
and spreading were achieved. Under the static and dynamic conditions,
prestained endothelial cells were quickly attached to the surface
at 25 °C via the integrin–cRGD interaction, and the cRGD
was the headgroup of the stretched PNIPAM below the LCST of PNIPAM.
With the increase of the temperature to 37 °C, a quick detachment
of cells from the surface was observed due to the cRGD moiety being
shielded by the antifouling LPG layer. As compared to current strategies
for endothelialization, for example, loaded drugs or growth factors,
such a tunable dynamic system based on “switchable surfaces”
may unlock new application in in situ targeted cell recruitment and
might become useful in regenerative medicine
High-Antifouling Polymer Brush Coatings on Nonpolar Surfaces via Adsorption-Cross-Linking Strategy
A new “adsorption-cross-linking”
technology is presented to generate a highly dense polymer brush coating
on various nonpolar substrates, including the most inert and low-energy
surfaces of polyÂ(dimethylsiloxane) and polyÂ(tetrafluoroethylene).
This prospective surface modification strategy is based on a tailored
bifunctional amphiphilic block copolymer with benzophenone units as
the hydrophobic anchor/chemical cross-linker and terminal azide groups
for in situ postmodification. The resulting polymer brushes exhibited
long-term and ultralow protein adsorption and cell adhesion benefiting
from the high density and high hydration ability of polyglycerol blocks.
The presented antifouling brushes provided a highly stable and robust
bioinert background for biospecific adsorption of desired proteins
and bacteria after secondary modification with bioactive ligands,
e.g., mannose for selective ConA and Escherichia coli binding