Study of the system of middle atmosphere-ionosphere using remote-sensing data

In the present investigation, the methods of statistical spectral analysis are employed for a study of the quasi-periodic changes of state parameters of the middle atmosphere and the ionosphere, taking into account oscillations with periods of several days. The considered oscillations are typical for planetary waves. The theory and empirical findings regarding transient planetary waves are utilized as a basis for the concepts employed in the data analysis and for the interpretation of the results. The results of the investigation show a presence of coherent variations in the time series of radiation density measurements and other state parameters for the middle atmosphere and the ionosphere. The existence of presumably dynamic coupling processes can be recognized in oscillations with periods of about 16 or 5 days

Massive MIMO-based Localization and Mapping Exploiting Phase Information of Multipath Components

In this paper, we present a robust multipath-based localization and mapping framework that exploits the phases of specular multipath components (MPCs) using a massive multiple-input multiple-output (MIMO) array at the base station. Utilizing the phase information related to the propagation distances of the MPCs enables the possibility of localization with extraordinary accuracy even with limited bandwidth. The specular MPC parameters along with the parameters of the noise and the dense multipath component (DMC) are tracked using an extended Kalman filter (EKF), which enables to preserve the distance-related phase changes of the MPC complex amplitudes. The DMC comprises all non-resolvable MPCs, which occur due to finite measurement aperture. The estimation of the DMC parameters enhances the estimation quality of the specular MPCs and therefore also the quality of localization and mapping. The estimated MPC propagation distances are subsequently used as input to a distance-based localization and mapping algorithm. This algorithm does not need prior knowledge about the surrounding environment and base station position. The performance is demonstrated with real radio-channel measurements using an antenna array with 128 ports at the base station side and a standard cellular signal bandwidth of 40 MHz. The results show that high accuracy localization is possible even with such a low bandwidth.Comment: 14 pages (two columns), 13 figures. This work has been submitted to the IEEE Transaction on Wireless Communications for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessibl

Purinergic and Calcium Signaling in Macrophage Function and Plasticity

In addition to a fundamental role in cellular bioenergetics, the purine nucleotide adenosine triphosphate (ATP) plays a crucial role in the extracellular space as a signaling molecule. ATP and its metabolites serve as ligands for a family of receptors that are collectively referred to as purinergic receptors. These receptors were first described and characterized in the nervous system but it soon became evident that they are expressed ubiquitously. In the immune system, purinergic signals regulate the migration and activation of immune cells and they may also orchestrate the resolution of inflammation (1, 2). The intracellular signal transduction initiated by purinergic receptors is strongly coupled to Ca2+-signaling and coordination of these pathways plays a critical role in innate immunity. In this review, we provide an overview of purinergic and Ca2+-signaling in the context of macrophage phenotypic polarization and discuss the implications on macrophage function in physiological and pathological conditions

Multipath-assisted maximum-likelihood indoor positioning using UWB signals

Multipath-assisted indoor positioning (using ultrawideband signals) exploits the geometric information contained in deterministic multipath components. With the help of a-priori available floorplan information, robust localization can be achieved, even in absence of a line-of-sight connection between anchor and agent. In a recent work, the Cramér-Rao lower bound has been derived for the position estimation variance using a channel model which explicitly takes into account diffuse multipath as a stochastic noise process in addition to the deterministic multipath components. In this paper, we adapt this model for position estimation via a measurement likelihood function and evaluate the performance for real channel measurements. Performance results confirm the applicability of this approach. A position accuracy better than 2.5 cm has been obtained in 90% of the estimates using only one active anchor at a bandwidth of 2GHz and robustness against non-line-of-sight situations has been demonstrated

NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration

Objective: We have previously shown that the transcription factor, nuclear factor of activated T-cells 5 (NFAT5), regulates vascular smooth muscle cell phenotypic modulation, but the role of NFAT5 in atherosclerosis is unknown. Our main objective was to determine if NFAT5 expression in bone marrow (BM)-derived cells altered atherosclerotic development and macrophage function. Methods and Results: NFAT5+/-ApoE-/- mice were generated for in vivo atherosclerosis studies. Following high fat diet feeding, en face analysis of the thoracic aorta established that genome-wide NFAT5 haploinsufficiency reduced atherosclerotic lesion formation by 73%. BM transplant studies revealed that transplantation of NFAT5+/-ApoE-/- marrow into NFAT5+/+ApoE-/- mice resulted in a similar 86% reduction in lesion formation. In vitro functional analysis of BM-derived macrophages demonstrated that NFAT5 is required for macrophage migration, which is a key event in the propagation of atherosclerosis. Conclusion: We have identified NFAT5 in BM-derived cells as a positive regulator of atherosclerotic lesion formation and macrophage function in the vasculature.open