Illustration of clinical relevance and potential usefulness of the simplified CI formula.

<p>Case 3: Significant increase of CI and muscle mass after start of hemodialysis (1st phase), loss of muscle mass after renal transplant rejection and rapid deterioration of CI following lung cancer leading to death (Pat. BJ, Male, 58 yo, 76.5 Kg, _spKT/V 1.33±0.18, CI 20.2±6.7 mg/kg/24 h).</p

Bland-Altman plot of the difference between equation-derived versus creatinine kinetic modeling-derived creatinine index.

<p>The horizontal lines are the mean difference and 95% limits of agreement.</p

Scatterplot between observed creatinine index and predicted creatinine index.

<p>A scatterplot with a regression line and a 95% confidence interval for the line representing the relationship between creatinine kinetic modeling (CKM)-derived creatinine index (Observed Cindex) and creatinine index derived from the equation (Predicted Cindex).</p

Difference plot analysis comparing equation-estimated CI and CKM- derived CI according to gender and age groups.

<p><i>Abbreviations</i>: CI, creatinine index; CKM, creatinine kinetic modeling; 95% CI, 95% confidence interval.</p

Clinical characteristics of hemodialysis patients used for the development of a simplified equation for the calculation of creatinine index.

<p><i>Note</i>: Qualitative variables expressed as number (percent). Quantitative variables expressed as mean ± SD for normally distributed variables or median [interquartile range] for non normally distributed variables;</p><p><i>Abbreviations</i>: HDF, hemodiafiltration; HD, hemodialysis; min, minutes.</p

Illustration of clinical relevance and potential usefulness of the simplified CI formula.

<p>Case 5: Slow decline of CI reflecting muscle mass loss in young heart transplant man then followed by a rapid CI decline due to development of liver cirrhosis (peliosis hepatitis) leading to death (Pat. KJ, Male, 53 yo, 61.9 Kg, Heart transplant - CV Catheters, _spKT/V 1.62±0.41, CI 22.1±5.9 mg/kg/24 h).</p

Clinical markers associated to increased coronary artery calcifications.

*<p>p-value (for variables with more than two categories, the p-value of the test for trend is given).</p

Biological markers associated to increased coronary artery calcifications after adjustment for age, gender, diabetes mellitus and smoking (the p-value of the test for trend is given).

<p>Biological markers associated to increased coronary artery calcifications after adjustment for age, gender, diabetes mellitus and smoking (the p-value of the test for trend is given).</p

Fibroblast growth factor 23 and Osteoprotegerin are differently associated to the severity of CAC.

<p>(A) Proportions of patients with normal (<173.30 RU/mL) or high (≥173.30 RU/mL) fibroblast growth factor 23 (FGF23) and normal (<10.71 pmol/L) or high (≥10.71 pmol/L) osteoprotegerin (OPG) levels within each coronary artery calcification (CAC) category. Sections of pie charts indicate proportions of patients with FGF23 and/or OPG levels by CAC category. (B) Prevalence rate ratio of CAC associated with increased levels of FGF23 and/or OPG levels.</p

Characteristics of the chronic kidney disease patients.

<p>Values were described by using proportions for categorical variables and median [range] for quantitative variables.</p