From Traditional to Innovative Assessment: The Case of Depression

This article reviews various approaches to the assessment of depression in deaf people as based on current research. Studies comparing traditional paper and pencil instrumentation with American Sign Language (ASL) video tape approaches are presented. Results indicate that both approaches do work with deaf clients, depending on language proficiency in either English or ASL. Exploration of computerized technology is warranted

Comparison of Face-to-Face and Video-Mediated Communication with Deaf Individuals: Implications for Telepsychotherapy

Telecommunications and videoconference systems are increasingly replacing face-to-face communication (F2F). Video-mediated communication (VMC) offers the benefit of virtual F2F communication over long distances. The purpose of this study was to compare communication performance and perceptions for deaf individuals in F2F and VMC situations using a Map Task. Deaf participants were instructed by a deaf instructor using American Sign Language to mark routes. There were no significant differences in the length of sessions, almost all communication breakdown events, map task deviations, and overall outcomes. The results suggest that effective communication can occur in VMC situations. Research is needed to gauge the effectiveness of VMC conditions in the delivery of mental health services including telepsychotherapy to deaf individuals who may not have access to local signing mental health services providers

Book Review

non

Impact of Communication on Depressive Vulnerability in Deaf Individuals

Mode of communication and perceived communication with mother deserve attention within the mother-deaf child relationship. This study explored the impact of both factors on each other and on the vulnerability of young deaf college students for depressive symptoms using measures revised to meet the language needs of this population. Depression was negatively associated with perceived communication with mother. Mode of communication significantly related to perceived communication with mother, with oral subjects scoring highest. They were also least depressed. Further analysis revealed that subjects communicating with their mothers through signs only and vice versa scored as high for perceived maternal communication as did oral subjects. This suggests that a good match between mother and child in mode of communication positively impacts on the young deaf adult\u27s emotional health

Social Identity in Deaf Culture: A Comparison of Ideologies

The emergence of Deaf culture and recent developments in identity research fueled by cultural diversity has ignited exploration of identity development in deaf people. The issue of how individuals go through the process of developing identities related to being deaf is now receiving much attention. Two major theoretical models in the literature, specifically racial identity development models and bicultural/acculturation models are presented and then discussed in terms of how they might apply to deaf people. Subsequently, we describe two separate measures that have been developed to empirically test the application of these models to deaf populations. While research on both measures indicates good psychometric properties, ongoing reconceptualization of social identity models that may explain how deaf people develop identities related to Deaf and hearing societies continues to be necessary. It is hoped that these measures will lead to better understanding of the relationship between aspects of identity and healthy psychological adjustment in deaf people

Reliability and Validity of the Adapter COPE Scale with Deaf College Students

The purpose of the current study was to investigate the reliability and validity of the Adapted Coping Operations Preference Enquiry (COPE) Scale with deaf college students. The Adapted COPE identifies15 strategies for managing stresors. 117 deaf college students from Gallaudet University, between the ages of 18 and 25, participated in the present study. When used with this sample, the majority of the Adapted COPE subscales evidenced high or moderate internal consistency reliability, except for the Mental Disengagement and Active Coping subscales. To investigate structural validity, principle component analysis was conducted utilizing quartimax rotation. Initial analyses retained 17 factors and failed to replicate the intended subscale structure of the measure. Post-hoc t-tests indicated that responses to the Original COPE by hearing participants and the Adapted COPE by deaf participants were largely similar, except for the Substance Use subscale, with significantly higher mean scores in the deaf sample. This suggests that the psychometric analyses of the original COPE scale indicate a need for additional restructuring of the measure

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

<div><p>Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deacetylase inhibitor, for the treatment and management of this disease. At 2 mg/kg, MS-275 significantly decreased tumor burden in an SKH-1 hairless mouse model of UVB radiation-induced skin carcinogenesis. MS-275 was cell permeable as a topical formulation and induced histone acetylation changes in mouse tumor tissue. MS-275 was also effective at inhibiting the proliferation of patient derived cutaneous squamous cell carcinoma lines and was particularly potent toward cells isolated from a regional metastasis on an immunocompromised individual. Our findings support the use of alternative routes of administration for histone deacetylase inhibitors in the treatment of high-risk squamous cell carcinoma which may ultimately lead to more precise delivery and reduced systemic toxicity.</p></div

HIV and adolescents: focus on young key populations

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138345/1/jia20076.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138345/2/jia20076-sup-0001.pd

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A&gt;T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

Lysyl hydroxylase 3 localizes to epidermal basement membrane and Is reduced in patients with Recessive Dystrophic Epidermolysis Bullosa

Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in COL7A1 resulting in reduced or absent type VII collagen, aberrant anchoring fibril formation and subsequent dermal-epidermal fragility. Here, we identify a significant decrease in PLOD3 expression and its encoded protein, the collagen modifying enzyme lysyl hydroxylase 3 (LH3), in RDEB. We show abundant LH3 localising to the basement membrane in normal skin which is severely depleted in RDEB patient skin. We demonstrate expression is in-part regulated by endogenous type VII collagen and that, in agreement with previous studies, even small reductions in LH3 expression lead to significantly less secreted LH3 protein. Exogenous type VII collagen did not alter LH3 expression in cultured RDEB keratinocytes and we show that RDEB patients receiving bone marrow transplantation who demonstrate significant increase in type VII collagen do not show increased levels of LH3 at the basement membrane. Our data report a direct link between LH3 and endogenous type VII collagen expression concluding that reduction of LH3 at the basement membrane in patients with RDEB will likely have significant implications for disease progression and therapeutic intervention