Improving the management of colorectal neoplasms in clinical practice

Colorectal cancer is one of the most frequent cancers in the Western world. Forty-five percent of symptomatic patients have metastatic disease. The overall prevalence of adenoma in an asymptomatic population is 25-30% at the age of 50 years and approximately two-thirds of all colonic polyps are adenomatous. Around 95% of CRCs evolve from an adenomatous polyp or sessile serrated lesion (SSL). Only 5% of all adenomatous polyps progress to CRC. To reduce both the incidence and mortality rate of CRC, a national bowel screening program started in January 2014. This thesis focussed on improving clinical care for patients with colorectal neoplasms. From identifying high risk persons/families through the national screening program to modifying a surgical technique to a minimal invasive organ-preserving technique for removal of colorectal neoplasms to the treatment of metastatic colorectal cancer. All studies are based on clinical questions arise from the daily practice. And is therefore also applicable in daily practice. Wetenschapsfonds Medisch specialisten Isala (WMI); Nederlandse Vereniging voor Gastro-Enterologie (NVGE)LUMC / Geneeskund

Equivalent Helicobacter pylori infection rates in Lynch syndrome mutation carriers with and without a first-degree relative with gastric cancer

Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Identification of familial colorectal cancer and hereditary colorectal cancer syndromes through the Dutch population-screening program: results ofa pilot study

Objectives: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance.Material and methods: This retrospective observational study was performed in two large hospitals. Individuals aged between 55 and 75 years with a positive I-FOBT that underwent colonoscopy were included. A detailed family history was obtained in all individuals.Results: A total of 657 individuals with a positive I-FOBT test underwent colonoscopy. A total of 120 (18.3%) participants were found to have a positive family history for CRC, 20 (3.0%) fulfilled the FCC criteria, 4 (0.6%) the Bethesda guidelines and 1 (0.2%) participant the Amsterdam criteria. Multiple adenomas (>10) were found in 21 (3.2%) participants. No cases of serrated polyposis were identified. Based on these criteria and guidelines, a total of 35 (5.3%) required referral to the clinical geneticist and the relatives of 20 (3.0%) participants should be referred for surveillance colonoscopy.Conclusion: Obtaining a detailed family history at the time of intake of participants with a positive I-FOBT in the Dutch surveillance program increased the identification of participants with familial CRC.Molecular tumour pathology - and tumour geneticsMTG2 - Moleculaire genetica van gastrointestinale tumore

Consequences of CT colonography in stenosing colorectal cancer

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Colonoscopic-Assisted Laparoscopic Wedge Resection for Colonic Lesions A Prospective Multicenter Cohort Study (LIMERIC-Study)

Objective: The aim of this study was to evaluate the safety and efficacy of a modified CAL-WR. Summary Background Data: The use of segmental colectomy in patients with endoscopically unresectable colonic lesions results in significant morbidity and mortality. CAL-WR is an alternative procedure that may reduce morbidity. Methods: This prospective multicenter study was performed in 13 Dutch hospitals between January 2017 and December 2019. Inclusion criteria were (1) colonic lesions inaccessible using current endoscopic resection techniques (judged by an expert panel), (2) non-lifting residual/recurrent adenomatous tissue after previous polypectomy or (3) an undetermined resection margin after endoscopic removal of a low-risk pathological T1 (pT1) colon carcinoma. Thirty-day morbidity, technical success rate and radicality were evaluated. Results: Of the 118 patients included (56% male, mean age 66 years, standard deviation +/- 8 years), 66 (56%) had complex lesions unsuitable for endoscopic removal, 34 (29%) had non-lifting residual/recurrent adenoma after previous polypectomy and 18 (15%) had uncertain resection margins after polypectomy of a pT1 colon carcinoma. CAL-WR was technically successful in 93% and R-0 resection was achieved in 91% of patients. Minor complications (Clavien-Dindo i-ii) were noted in 7 patients (6%) and an additional oncologic segmental resection was performed in 12 cases (11%). Residual tissue at the scar was observed in 5% of patients during endoscopic follow-up. Conclusions: CAL-WR is an effective, organ-preserving approach that results in minor complications and circumvents the need for major surgery. CAL-WR, therefore, deserves consideration when endoscopic excision of circumscribed lesions is impossible or incomplete.Cellular mechanisms in basic and clinical gastroenterology and hepatolog

Improving the management of colorectal neoplasms in clinical practice

Colorectal cancer is one of the most frequent cancers in the Western world. Forty-five percent of symptomatic patients have metastatic disease. The overall prevalence of adenoma in an asymptomatic population is 25-30% at the age of 50 years and approximately two-thirds of all colonic polyps are adenomatous. Around 95% of CRCs evolve from an adenomatous polyp or sessile serrated lesion (SSL). Only 5% of all adenomatous polyps progress to CRC. To reduce both the incidence and mortality rate of CRC, a national bowel screening program started in January 2014. This thesis focussed on improving clinical care for patients with colorectal neoplasms. From identifying high risk persons/families through the national screening program to modifying a surgical technique to a minimal invasive organ-preserving technique for removal of colorectal neoplasms to the treatment of metastatic colorectal cancer. All studies are based on clinical questions arise from the daily practice. And is therefore also applicable in daily practice. </p

Improving the management of colorectal neoplasms in clinical practice

Colorectal cancer is one of the most frequent cancers in the Western world. Forty-five percent of symptomatic patients have metastatic disease. The overall prevalence of adenoma in an asymptomatic population is 25-30% at the age of 50 years and approximately two-thirds of all colonic polyps are adenomatous. Around 95% of CRCs evolve from an adenomatous polyp or sessile serrated lesion (SSL). Only 5% of all adenomatous polyps progress to CRC. To reduce both the incidence and mortality rate of CRC, a national bowel screening program started in January 2014. This thesis focussed on improving clinical care for patients with colorectal neoplasms. From identifying high risk persons/families through the national screening program to modifying a surgical technique to a minimal invasive organ-preserving technique for removal of colorectal neoplasms to the treatment of metastatic colorectal cancer. All studies are based on clinical questions arise from the daily practice. And is therefore also applicable in daily practice. </p

Referrals for surgical removal of polyps since the introduction of a colorectal cancer screening programme

Aim Implementation of the Dutch national bowel screening programme in 2014 led to an increased rate of detection of polyps. In general, polyps should be removed endoscopically. However, if the size and location of the polyp make endoscopic removal technically difficult, or if there is a suspicion for early (T1) cancer, surgery is the preferred method for removal. An increasing number of these patients are being treated with minimally invasive surgical procedures instead of segmental resection. The aim of this study was to assess the number of referrals for surgery and the type of surgery for polyps since the introduction of the Dutch national bowel screening programme.Method A retrospective cohort study was performed. Patients who underwent surgery for colorectal polyps between January 2012 and December 2017 were included. Patients with histologically proven carcinoma prior to surgery were excluded. Primary outcomes were the number and type of surgical procedures for polyps.Results A total of 164 patients were included. An annual increase in procedures for colorectal polyps was observed, from 18 patients in 2012 to 36 patients in 2017. All the procedures before implementation of the screening programme were segmental resections, and 58.8% of the patients underwent organ-preserving surgery after implementation of the screening. The overall complication rate of organ-preserving surgery was 16.3%, compared with 44.3% for segmental resections (P = 0.001). Overall, invasive colorectal cancer was encountered in 23.8% of cases.Conclusion The number of referrals for surgical resection of colorectal polyps has doubled since the introduction of the Dutch national bowel screening programme with a substantial shift towards organ-preserving techniques.Surgical oncolog