23 research outputs found
Entrainer-Assisted Pressure-Swing Distillation for Separating the Minimum-Boiling Azeotrope Toluene/Pyridine: Design and Control
The separation of toluene/pyridine
by distillation still remains
an obstacle in industry because of not only the formation of a minimum-boiling
azeotrope but also their relative volatilities, whose ratio is close
to unity throughout the whole composition range. Extractive distillation
is still not feasible because it is hard to find suitable entrainers.
Heterogeneous azeotropic distillation might require high energy consumption
to obtain both purified products. Conventional pressure-swing distillation
is also not feasible. In this work, we apply entrainer-assisted pressure-swing
distillation to separate toluene/pyridine (95 mol %/5 mol %) by introducing <i>n</i>-propanol as an entrainer. Based on the different compositions
of the recycling stream sent back to the azeotropic column, a two-column
sequence and a three-column sequence are established. Both sequences
are partially heat-integrated. The steady-state designs of both sequences
are optimized based on the total annual cost (TAC). The results reveal
that the optimal two-column sequence has a 16.07% reduction of TAC
and a 14.39% energy savings compared with the three-column sequence.
Furthermore, the dynamic controllability of the two-column sequence
is investigated by introducing ±10% disturbances in the feed
flow rate and ±20% disturbances in the pyridine concentration.
A conventional temperature control structure is implemented. As the
fresh feed is quite dilute in pyridine, the purity of the pyridine
product will be significantly influenced by even a small change in
the recycling-stream flow rate. Therefore, the recycling-stream flow
rate must be selected as a manipulated variable that is manipulated
to control the pyridine product purity. The results reveal that robust
control can be achieved
Image_1_Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis.TIF
BackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger’s linear regression test and a funnel plot.ResultsSixteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.69, 95% CI 1.48–1.93; multivariate analysis: HR 1.69; 95% CI 1.39–2.05, I2 = 77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (Change to univariate analysis: HR 1.74, 95% CI 1.47–2.05; multivariate analysis: HR 1.54; 95% CI 1.23–1.93, I2 = 63%).ConclusionSarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.Systematic review registrationRegistration ID: CRD42023438208 https://www.crd.york.ac.uk/PROSPERO/#recordDetails.</p
Image_4_Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis.TIF
BackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger’s linear regression test and a funnel plot.ResultsSixteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.69, 95% CI 1.48–1.93; multivariate analysis: HR 1.69; 95% CI 1.39–2.05, I2 = 77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (Change to univariate analysis: HR 1.74, 95% CI 1.47–2.05; multivariate analysis: HR 1.54; 95% CI 1.23–1.93, I2 = 63%).ConclusionSarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.Systematic review registrationRegistration ID: CRD42023438208 https://www.crd.york.ac.uk/PROSPERO/#recordDetails.</p
Image_2_Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis.TIF
BackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger’s linear regression test and a funnel plot.ResultsSixteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.69, 95% CI 1.48–1.93; multivariate analysis: HR 1.69; 95% CI 1.39–2.05, I2 = 77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (Change to univariate analysis: HR 1.74, 95% CI 1.47–2.05; multivariate analysis: HR 1.54; 95% CI 1.23–1.93, I2 = 63%).ConclusionSarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.Systematic review registrationRegistration ID: CRD42023438208 https://www.crd.york.ac.uk/PROSPERO/#recordDetails.</p
Table_1_Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis.docx
BackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger’s linear regression test and a funnel plot.ResultsSixteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.69, 95% CI 1.48–1.93; multivariate analysis: HR 1.69; 95% CI 1.39–2.05, I2 = 77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (Change to univariate analysis: HR 1.74, 95% CI 1.47–2.05; multivariate analysis: HR 1.54; 95% CI 1.23–1.93, I2 = 63%).ConclusionSarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.Systematic review registrationRegistration ID: CRD42023438208 https://www.crd.york.ac.uk/PROSPERO/#recordDetails.</p
Obtaining Reversible, Durable, High-Contrast Photochromism and Antibacterial Properties in a Flexible, Wearable Fiber Using Nanometer-Sized Polyoxotungstate
An approach to preparing a functional fiber has been
developed.
The method is carried out to link nanometer-sized polyoxometalate
and cotton fabric by employing a cationic agent. Interestingly, the
composite fabric exhibits a broad absorption peak in the visible range
after irradiation, accompanied by obvious color changes from white
to blue owing to electron transfer. The W(VI) transforms into a heteropoly
blue W(V) rapidly (<5 s) in response to UV irradiation with a low-power
UV (5 W), whereas its recovery seems slightly slow (5 h) in the air.
Nevertheless, increasing the temperature can accelerate the fading
process. Further, the continuous coloring–fading process presents
outstanding repetition stability. Additionally, the composite fabric
shows a degree of antibacterial property. Meanwhile, the physical
properties indicate that multifunctional cotton retains natural features
after chemical modification. In a word, the reversible photoresponsive
cellulose fabric can be a promising candidate for developing a wearable
and flexible sensor to monitor environmental changes
Image_3_Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis.TIF
BackgroundNumerous studies have reported sarcopenia to be associated with unfavorable outcomes in patients who have undergone pancreatectomy. Therefore, in this meta-analysis, we examined the relationship between sarcopenia and survival after pancreatic surgery.MethodsPubMed, Embase, and Cochrane Library were searched for studies that examined the association between sarcopenia and survival after pancreatic surgery from the inception of the database until June 1, 2023. Hazard ratio (HR) for overall survival (OS) and/or progression-free survival (PFS) of sarcopenia and pancreatic surgery were extracted from the selected studies and random or fixed-effect models were used to summarize the data according to the heterogeneity. Publication bias was assessed using Egger’s linear regression test and a funnel plot.ResultsSixteen studies met the inclusion criteria. For 13 aggregated univariate and 16 multivariate estimates, sarcopenia was associated with decreased OS (univariate analysis: HR 1.69, 95% CI 1.48–1.93; multivariate analysis: HR 1.69; 95% CI 1.39–2.05, I2 = 77.4%). Furthermore, sarcopenia was significantly associated with poor PFS of pancreatic resection (Change to univariate analysis: HR 1.74, 95% CI 1.47–2.05; multivariate analysis: HR 1.54; 95% CI 1.23–1.93, I2 = 63%).ConclusionSarcopenia may be a significant prognostic factor for a shortened survival following pancreatectomy since it is linked to an elevated risk of mortality. Further studies are required to understand how sarcopenia affects long-term results after pancreatic resection.Systematic review registrationRegistration ID: CRD42023438208 https://www.crd.york.ac.uk/PROSPERO/#recordDetails.</p
Multiple Steady-States Analysis and Unstable Operating Point Stabilization in Homogeneous Azeotropic Distillation with Intermediate Entrainer
The
steady-state multiplicity in azeotropic distillation processes
has been theoretically predicted and verified experimentally for decades.
However, it is a tough task to detect all the steady-state solutions.
The purpose of this article is 2-fold: first, it provides a systematical
study on the multiplicity in homogeneous azeotropic distillation with
intermediate entrainer and a novel strategy is proposed to find all
the steady-state solutions using “Design Specs/Vary”
in Aspen Plus. Operating on the unstable steady-state branch benefits
both energy saving and reducing capital investment with the product
quality specified. Because of the great benefits that operating on
the unstable steady-state branch offers, the second purpose is to
present suitable control schemes to stabilize the operating point
on the unstable steady-state branch to achieve robust control
Kaplan-Meier analysis of disease-free survival (DFS) in renal cell carcinoma according to expression of the EZH2 or H3K27me3 score.
<p>(A), (D) all patients in the training set. (B), (E) patients with I+II stage disease in the training set. (C), (F) patients with III+IV stage disease in the training set. (G), (J) all patients in the validation set. (H), (K) patients with I+II stage disease in the validation set. (I), (L) patients with III+IV stage disease in the validation set. </p
Spinel (Mn, Fe)<sub>3</sub>O<sub>4</sub> Nanocatalyst for the Catalytic Ozone Decomposition under Humid Conditions
The
development of ozone-decomposition catalysts with high efficiency
and exceptional resistance to humidity is a significant challenge,
as ozone is a primary air pollutant. This study successfully synthesized
a series of MnxFe3–xO4 catalysts with varying crystal structures
by adjusting the Mn/Fe molar ratios through a coprecipitation method
with inorganic salt precursors. Compared to crystalline Mn3O4 and Fe2O3, the obtained amorphous
MnFe2O4(MnFe-1) nanocatalyst exhibited an optimal
ozone conversion rate of 99.9% for 50 ppm O3 with a space
velocity (SV) of 600 L g–1 h–1 in dry gas and 77.4% for 50 ppm O3 with a SV of 600
L g–1 h–1 under a relative humidity
(RH) of 60%. The superior performance of the amorphous sample can
be attributed not only to its smaller size and larger surface area
but also to the presence of Mn3+ as the active site, a
higher number of oxygen vacancies and acid sites, and the synergistic
effect between iron and manganese. This research offers a universally
applicable preparation method for nanosized spinel oxides and provides
an in-depth exploration of the ozone-decomposition mechanism