(E)-1-(4-Chloro­phen­yl)-3-[4-(dimethyl­amino)phen­yl]prop-2-en-1-one

The title compound, C17H16ClNO, was synthesized using a solvent-free method by reaction of 4-(dimethyl­amino)benzaldehyde with 4-chloro­acetophenone and NaOH. The chloro­phenyl ring makes a dihedral angle of 18.1 (3)° with the central propenone unit, while the (dimethyl­amino)phenyl group is disordered over two orientations of equal occupancies, which make dihedral angles with the central propenone unit of 32.9 (3) and 57.4 (3)°, respectively

FER Based on Fusion Features of CS-LSMP

Local feature descriptors play a fundamental and important role in facial expression recognition. This paper presents a new descriptor, Center-Symmetric Local Signal Magnitude Pattern (CS-LSMP), which is used for extracting texture features from facial images. CS-LSMP operator takes signal and magnitude information of local regions into account compared to conventional LBP-based operators. Additionally, due to the limitation of single feature extraction method and in order to make full advantages of different features, this paper employs CS-LSMP operator to extract features from Orientational Magnitude Feature Maps (OMFMs), Positive-and-Negative Magnitude Feature Maps (PNMFMs), Gabor Feature Maps (GFMs) and facial patches (eyebrows-eyes, mouths) for obtaining fused features. Unlike HOG, which only retains horizontal and vertical magnitudes, our work generates Orientational Magnitude Feature Maps (OMFMs) by expanding multi-orientations. This paper build two distinct feature maps by dividing local magnitudes into two groups, i.e., positive and negative magnitude feature maps. The generated Gabor Feature Maps (GFMs) are also grouped to reduce the computational complexity. Experiments on the JAFFE and CK+ facial expression datasets showed that the proposed framework achieved significant improvement and outperformed some state-of-the-art methods

Multiobjective Location Model Design Based on Government Subsidy in the Recycling of CDW

With the generation of a large amount of construction and demolition waste (CDW), many scholars have recently paid more attention to the recycling of CDW. In this paper, we design a classification recycling method based on the degree of CDW availability in the recycling of CDW. Considering the important role of the government in reverse logistics, a model of reverse logistics network based on the trade-off between cost and recycling rate is put forward, which is subject to government subsidy. The model includes the location of classification processing center and ensures the best route of transportation. Then, the improved particle swarm optimization algorithm is applied to solve the model to get Pareto frontier by transforming it into a multiobjective integer-programming problem. As a case study, the results of the statistical modeling used in this study indicate the feasibility of the model. Finally, according to the sensitivity analysis of government’s subsidy, we evaluate the effectiveness of this program and its applicability

Fine structure interpretation and reservoir forming characteristics analysis of Jurassic Badaowan Formation in Madong area of Xiayan fault zone

Fine structural interpretation is one of the effective methods to find favorable structural traps and targets. Aiming at the fault interpretation of Jurassic Badaowan Fm in Madong area of Xiayan fault zone is not fine and structural characteristics are not implemented, the structural characteristics of Jurassic Badaowan Fm are implemented and favorable traps are found through the study of seismic, well logging and geological comprehensive methods. The results show that the structure of Jurassic Badaowan Fm in Madong area is high in the north and low in the south. The first member of Badaowan Fm is a delta front subaqueous distributary channel deposit, which is a hydrocarbon enrichment zone. Oil and gas are adjusted along the relay of deep and shallow faults, and the great fault zone and the inherited uplifting zone are favorable accumulation areas of Jurassic Badaowan Fm in Madong area. In this paper, the relationship between deep and shallow fault system and hydrocarbon distribution of Badaowan Fm in Madong area is systematically reviewed for the first time. Combined with the palaeohigh distribution, three favorable hydrocarbon accumulation zones are identified, which provides favorable targets for exploring the hydrocarbon accumulation potential of Badaowan Fm

Deep muscularis propria tumor invasion without lymph node metastasis as a unique subclassification of stage IB gastric cancer: a retrospective study

BACKGROUND: The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated, and therapy strategy for stage IB GC patient required further investigation. METHODS: A total of 380 patients with pT2 GC after radical surgery were retrospectively analyzed, including 185 in superficial muscularis propria (sMP) group and 195 in deep muscularis propria (dMP) group. RESULTS: The overall survival (OS) was significantly better for patients in sMP group than for patients in dMP group (P = 0.007). In multivariate analysis, depth of tumor invasion, pN stage, age, primary location, positive expression of p53, elevated maximal LDH, elevated initial CA19-9 and AFP level were independent prognostic factors for OS. The sMP group had a significantly better OS than dMP group (P = 0.014) in pN0 stage. After further stratification, the survival outcomes were not significantly different between deep muscularis propria tumor invasion without lymph node metastasis (dMPN0) group (stage IB) and superficial muscularis propria tumor invasion with stage 1-2 lymph node metastasis (sMPN1-2) group (stage II) (P = 0.100). Patients with adjuvant chemotherapy had a statistically better survival than those without in dMPN0 group (P = 0.045) and dMPN0 patients with adjuvant chemotherapy had better OS than sMPN1-2 patients (P = 0.015). In addition, greater postoperative survival could be observed in sMPN0 patients than dMPN0 patients in p53-positive group (P = 0.002), and similar OS could be seen between dMPN0 patients with p53-positive and T2N1-2 patients (P = 0.872). CONCLUSION: As a unique subclassification of stage IB GC, appropriate adjuvant chemotherapy should be considered for patients with dMPN0 stage. In addition, positive expression of p53, elevated LDH could be potential factors in identifying the different prognoses for stage IB GC patients

Research progress on the role of vitamin D supplementation in adjuvant therapy for COVID-19

The pandemic caused by coronavirus disease of 2019 （COVID-19） has brought severe challenges to public health all over the world. Vitamin D plays an important role in immune regulation and anti-respiratory virus infection as an immune enhancer. Several studies have demonstrated that vitamin D can regulate the angiotensin-converting enzyme 2/angiotensin （1-7）/Mas receptor axis signaling pathway， inhibit the over-activation of renin-angiotensin system signal， fight against SARS-CoV-2 infection and suppress the production of inflammatory cytokine storm， thereby reducing the risk of pneumonia infection and improving acute respiratory distress syndrome， cardiogenic obstruction and thrombosis in COVID-19 patients. In this article， the mechanism of vitamin D in reducing the risk of SARS-CoV-2 infection and mitigating clinical symptoms was reviewed. It is hypothesized that vitamin D plays a critical role in the prevention or adjuvant therapy for novel coronavirus pneumonia and alleviating clinical manifestations in COVID-19 patients

Toward Full Accounting for Leakage Exploitation and Mitigation in Dynamic Encrypted Databases

Encrypted database draws much attention as it provides privacy-protection services for sensitive data outsourced to a third party. Recent studies show that the security guarantee of encrypted databases are challenged by several leakage-abuse attacks on its search module, and corresponding countermeasures are also proposed. Most of these studies focus on static databases, yet the case for dynamic has not been well investigated. To fill this gap, in this paper, we focus on exploring privacy risks in dynamic encrypted databases and devising effective mitigation techniques. To begin with, we systematically study the exploitable information disclosed during the database querying process, and consider two types of attacks that can recover encrypted queries. The first active attack works by injecting encoded files and correlating file volume information. The second passive attack works by identifying queries’ unique relational characteristics across updates, assuming certain background knowledge of plaintext databases. To mitigate these attacks, we propose a two-layer encrypted database hardening approach, which obfuscates both search indexes and files in a continuous way. As a result, the unique characteristics emerging after data updates can be eliminated constantly. We conduct a series of experiments to confirm the severity of our attacks and the effectiveness of our countermeasures

Epidemiology and grade 2 disability of leprosy among migrant and resident patients in Guangdong: an unignorable continued transmission of leprosy

IntroductionLeprosy remains a major public health concern worldwide and one of the leading causes of disability. New cases of leprosy with grade 2 disability (G2D) often reflect delayed detection due to the limited capacity of the health system to recognize leprosy early. This study aimed to describe the epidemiology and G2D of leprosy among migrant and resident patients with leprosy in Guangdong province, China.MethodsData on newly diagnosed cases of leprosy were collected from the leprosy management information system in China. Descriptive statistical analysis was used to describe the status of G2D. Joinpoint regression model and logistic regression were performed to analyze the temporal trends and influencing factors for G2D.ResultsThe G2D rate among migrant, resident, and total patients with leprosy was 17.5%, 18.7%, and 18.4%, respectively. The total G2D rate increased significantly from 18.0% in 2001 to 25.7% in 2021 (average annual per cent change: 2.5%). Multivariate analysis revealed that factors that negatively influence G2D between migrant and resident patients included delayed discovery time (migrants: OR = 2.57; residents: OR = 4.99) and nerve damage when diagnosed (migrants: OR = 9.40; residents: OR = 21.28).DiscussionOur findings indicate that the targeted intervention measures implemented by our health system are urgently needed to improve the current situation, such as programs to promote early detection, strengthen awareness and skills of healthcare workers, and rehabilitation for disabled patients to improve their quality of life