Hodgkin en de classificatie van maligne lymfomen : Hoe de britse arts ook later ontdekte lymfomen aan zich wist te binden

Thomas Hodgkin beschreef als eerste een maligne lymfoom, dat later zijn naam zou krijgen. Daarna werden andere lymfoïde maligniteiten herkend die niet op Hodgkins ziekte leken. Deze werden genoemd naar de op dat moment geldende morfologische nomenclatuur van de betrokken cellen. Later werd de naamgeving mede bepaald door immunologische kenmerken. Maar nog steeds wordt de groep van lymfomen die ontdekt zijn na Hodgkins beschrijving aangeduid als zijnde ‘geen ziekte van Hodgkin’: non-Hodgkin-lymfoom. Wij vinden het ongewenst dat de man wiens lymfoom zo algemeen bekend is, zelf zo onbekend is. In dit artikel geven wij daarom een historisch overzicht van Thomas Hodgkin, ‘zijn’ lymfoom en de andere maligne lymfomen

First report of IgG4 related disease primary presenting as vertebral bone marrow lesions

IgG4-related disease is a fibro-inflammatory disorder characterized by swelling of tissues and affected organs accompanied by the development of scar tissue (fibrosis) and infiltration by IgG4 positive plasma cells. Almost any organ can be affected, including, but rarely, bone marrowinvolvement. Here we present a case of a 76-year-old male with IgG4-related disease presenting primarily with vertebral bone marrow lesions. Histopathology showed the typical features of storiform fibrosis, and increased IgG4 positive plasma cells. Treatment with corticosteroids significantly improved wellbeing and resolved lesion size on MRI

Whole slide images for primary diagnostics of gastrointestinal tract pathology: a feasibility study

During the last decade, whole slide images have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation, and quality assurance testing. However, whole slide images have as yet not much been used for up-front diagnostics because of the lack of validation studies. The aim of this study was, therefore, to test the feasibility of whole slide images for diagnosis of gastrointestinal tract specimens, one of the largest areas of diagnostic pathology. One hundred gastrointestinal tract biopsies and resections that had been diagnosed using light microscopy 1 year before were rediagnosed on whole slide images scanned at ×20 magnification by 5 pathologists (all reassessing their own cases), having the original clinical information available but blinded to their original light microscopy diagnoses. The original light microscopy and whole slide image-based diagnoses were compared and classified as concordant, slightly discordant (without clinical consequences), and discordant. The diagnoses based on light microscopy and the whole slide image-based rediagnoses were concordant in 95% of the cases. Light microscopy and whole slide image diagnosis in the remaining 5% of cases were slightly discordant, none of these were with clinical or prognostic implications. Up-front histopathologic diagnosis of gastrointestinal biopsies and resections can be done on whole slide image