2,987 research outputs found
Self-Organized Criticality Effect on Stability: Magneto-Thermal Oscillations in a Granular YBCO Superconductor
We show that the self-organized criticality of the Bean's state in each of
the grains of a granular superconductor results in magneto-thermal oscillations
preceding a series of subsequent flux jumps. We find that the frequency of
these oscillations is proportional to the external magnetic field sweep rate
and is inversely proportional to the square root of the heat capacity. We
demonstrate experimentally and theoretically the universality of this
dependence that is mainly influenced by the granularity of the superconductor.Comment: submitted to Physical Review Letters, 4 pages, RevTeX, 4 figures
available as uufile
An imaging and spectroscopic study of the very metal-deficient blue compact dwarf galaxy Tol 1214--277
We present a spectrophotometric study based on VLT/FORS I observations of one
of the most metal-deficient blue compact dwarf (BCD) galaxies known, Tol
1214-277 (Z ~ Zsun/25). The data show that roughly half of the total luminosity
of the BCD originates from a bright and compact starburst region located at the
northeastern tip of a faint dwarf galaxy with cometary appearance. The
starburst has ignited less than 4 Myr ago and its emission is powered by
several thousands O7V stars and ~ 170 late-type nitrogen Wolf-Rayet stars
located within a compact region with < 500 pc in diameter. For the first time
in a BCD, a relatively strong [Fe V] 4227 emission line is seen which together
with intense He II 4686 emission indicates the presence of a very hard
radiation field in Tol 1214-277. We argue that this extraordinarily hard
radiation originates from both Wolf--Rayet stars and radiative shocks in the
starburst region. The structural properties of the low-surface-brightness (LSB)
component underlying the starburst have been investigated by means of surface
photometry down to 28 B mag/sq.arcsec. We find that, for a surface brightness
level fainter than ~ 24.5 B mag/sq.arcsec, an exponential fitting law provides
an adequate approximation to its radial intensity distribution. The broad-band
colors in the outskirts of the LSB component of Tol 1214-277 are nearly
constant and are consistent with an age below one Gyr. This conclusion is
supported by the comparison of the observed spectral energy distribution (SED)
of the LSB host with theoretical SEDs.Comment: 17 pages, 11 Postscript figures, uses emulateapj.sty, to appear in
Astronomical Journa
Hydrogenation of CO on a silica surface: an embedded cluster approach
The sequential addition of H atoms to CO adsorbed on a siliceous edingtonite surface is studied with an embedded cluster approach, using density functional theory for the quantum mechanical (QM) cluster and a molecular force field for the molecular mechanical (MM) cluster. With this setup, calculated QM/MM adsorption energies are in agreement with previous calculations employing periodic boundary conditions. The catalytic effect of the siliceous edingtonite (100) surface on CO hydrogenation is assessed because of its relevance to astrochemistry. While adsorption of CO on a silanol group on the hydroxylated surface did not reduce the activation energy for the reaction with a H atom, a negatively charged defect on the surface is found to reduce the gas phase barriers for the hydrogenation of both CO and H2C = O. The embedded cluster approach is shown to be a useful and flexible tool for studying reactions on (semi-)ionic surfaces and specific defects thereon. The methodology presented here could easily be applied to study reactions on silica surfaces that are of relevance to other scientific areas, such as biotoxicity of silica dust and geochemistry
A spectroscopic study of component C and the extended emission around I Zw 18
Long-slit Keck II, 4m Kitt Peak, and 4.5m MMT spectrophotometric data are
used to investigate the stellar population and the evolutionary status of I Zw
18C, the faint C component of the nearby blue compact dwarf galaxy I Zw 18.
Hydrogen H and H emission lines are detected in the spectra of I
Zw 18C, implying that ionizing massive stars are present. High signal-to-noise
Keck II spectra of different regions in I Zw 18C reveal H, H
and higher order hydrogen lines in absorption. Several techniques are used to
constrain the age of the stellar population in I Zw 18C. Ages derived from two
different methods, one based on the equivalent widths of the H,
H emission lines and the other on H, H absorption lines
are consistent with a 15 Myr instantaneous burst model. We find that a small
extinction in the range = 0.20 -- 0.65 mag is needed to fit the observed
spectral energy distribution of I Zw 18C with that model. In the case of
constant star formation, all observed properties are consistent with stars
forming continuously between ~ 10 Myr and < 100 Myr ago. We use all available
observational constraints for I Zw 18C, including those obtained from Hubble
Space Telescope color-magnitude diagrams, to argue that the distance to I Zw 18
should be as high as ~ 15 Mpc. The deep spectra also reveal extended ionized
gas emission around I Zw 18. H emission is detected as far as 30" from
it. To a B surface brightness limit of ~ 27 mag arcsec we find no
observational evidence for extended stellar emission in the outermost regions,
at distances > 15" from I Zw 18.Comment: 38 pages, 11 Postscript figures, accepted for publication in the
Astrophysical Journa
What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?
The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported increased bone marrow vascularity and elevation of angiogenic cytokines in acute lymphoblastic leukaemia (ALL). VEGF and basic fibroblast growth factor (bFGF) are the major proangiogenic cytokines that have been studied, and evaluation of their prognostic impact in childhood ALL has been reported in several studies, though with controversial results. The antiangiogenic response, contributing to the angiogenic balance, has scarcely been reported. The origin of the factors, their prognostic value, and their relevance as good markers of what really happens in the bone marrow are discussed in this paper. The place of antiangiogenic drugs in ALL has to be defined in the global treatment strategy
Treatment of endometriosis by aromatase inhibitors: efficacy and side effects
The recent demonstration that aromatase is expressed at higher levels in endometriosis implants than in normal endometrium has led to pilot studies using inhibitor aromatasis in patients with endometriosis. We conducted a systematic review of the literature and studied the efficacy of aromatase inhibitors on endometriosis. There were seventeen studies (case reports/series) evaluating outcomes of aromatase inhibitors. Studies suggest that aromatase inhibitors alone or co-administered with progestins, oral contraceptives or gonadotrophin releasing hormone (GnRH) agonist could reduce pain and endometriosis. There is only one randomized controlled trial comparing aromatase inhibitor+GnRH agonist and GnRH agonist and one study with eighty patients. Side-effects profiles of aromatase inhibitor regimens are favorable; it does not appear a significant bone loss. Aromatase inhibitors seem to have a promising effect on endometriosis but randomized controlled trials are needed to prove their effects and their safety
O089: Recurrent transmission of group a streptococcus pyogenes (GAS) during surgery by a health care worker (HCW)
Spectral statistics of chaotic systems with a point-like scatterer
The statistical properties of a Hamiltonian perturbed by a localized
scatterer are considered. We prove that when describes a bounded chaotic
motion, the universal part of the spectral statistics are not changed by the
perturbation. This is done first within the random matrix model. Then it is
shown by semiclassical techniques that the result is due to a cancellation
between diagonal diffractive and off-diagonal periodic-diffractive
contributions. The compensation is a very general phenomenon encoding the
semiclassical content of the optical theorem.Comment: 11 pages, no figure
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation
The promising drug target N-myristoyltransferase (NMT) catalyses an essential protein modification thought to occur exclusively at N-terminal glycines (Gly). Here, we present high-resolution human NMT1 structures co-crystallised with reactive cognate lipid and peptide substrates, revealing high-resolution snapshots of the entire catalytic mechanism from the initial to final reaction states. Structural comparisons, together with biochemical analysis, provide unforeseen details about how NMT1 reaches a catalytically competent conformation in which the reactive groups are brought into close proximity to enable catalysis. We demonstrate that this mechanism further supports efficient and unprecedented myristoylation of an N-terminal lysine side chain, providing evidence that NMT acts both as N-terminal-lysine and glycine myristoyltransferase
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