Liver regeneration in dogs: Morphologic and chemical changes

Forty-four percent and 72% hepatectomy were carried out in dogs and the animals were sacrificed for biochemical and pathologic studies from 0.5 to 6 days later. Compensatory hypertrophy and hyperplasia ("regeneration") were evident within 1 day, reached a maximum in 3 days, and were almost complete by 6 days. Coincident with the histologic events of regeneration were decreases in responsiveness of receptor adenyl cyclase to glucagon stimulation, increases of cyclic AMP, inconsistent changes in plasma insulin, and increases in plasma glucagon. These studies have standardized hepatic resection in dogs and they have focused attention upon some possible mechanisms that will require further study. © 1978 Academic Press, Inc. All rights of reserved

Character Strengths Among Youth

Four hundred and fiftynine students from 20 different high school classrooms in Michigan participated in focus group discussions about the character strengths included in the Values in Action Classification. Students were interested in the subject of good character and able to discuss with candor and sophistication instances of each strength. They were especially drawn to the positive traits of leadership, practical intelligence, wisdom, social intelligence, love of learning, spirituality, and the capacity to love and be loved. Students believed that strengths were largely acquired rather than innate and that these strengths developed through ongoing life experience as opposed to formal instruction. They cited an almost complete lack of contemporary role models exemplifying different strengths of character. Implications of these findings for the quantitative assessment of positive traits were discussed, as were implications for designing character education programs for adolescents. We suggest that peers can be an especially important force in encouraging the development and display of good character among youth.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45293/1/10964_2004_Article_379439.pd

Stroke in women — from evidence to inequalities

Stroke is the second largest cause of disability-adjusted life-years lost worldwide. The prevalence of stroke in women is predicted to rise rapidly, owing to the increasing average age of the global female population. Vascular risk factors differ between women and men in terms of prevalence, and evidence increasingly supports the clinical importance of sex differences in stroke. The influence of some risk factors for stroke — including diabetes mellitus and atrial fibrillation — are stronger in women, and hypertensive disorders of pregnancy also affect the risk of stroke decades after pregnancy. However, in an era of evidence-based medicine, women are notably under-represented in clinical trials — despite governmental actions highlighting the need to include both men and women in clinical trials — resulting in a reduced generalizability of study results to women. The aim of this Review is to highlight new insights into specificities of stroke in women, to plan future research priorities, and to influence public health policies to decrease the worldwide burden of stroke in women