The Preservation of Cued Recall in the Acute Mentally Fatigued State: A Randomised Crossover Study.

The objective of this study is to investigate the impact of acute mental fatigue on the recall of clinical information in the non-sleep-deprived state. Acute mental fatigue in the non-sleep-deprived subject is rarely studied in the medical workforce. Patient handover has been highlighted as an area of high risk especially in fatigued subjects. This study evaluates the deterioration in recall of clinical information over 2 h with cognitively demanding work in non-sleep-deprived subjects.A randomised crossover study involving twenty medical students assessed free (presentation) and cued (MCQ) recall of clinical case histories at 0 and 2 h under low and high cognitive load using the N-Back task. Acute mental fatigue was assessed through the Visual Analogue Scale, Stanford Scale and NASA-TLX Mental Workload Rating Scale.Free recall is significantly impaired by increased cognitive load (p < 0.05) with subjects demonstrating perceived mental fatigue during the high cognitive load assessment. There was no significant difference in the amount of information retrieved by cued recall under high and low cognitive load conditions (p = 1).This study demonstrates the loss of clinical information over a short time period involving a mentally fatiguing, high cognitive load task. Free recall for the handover of clinical information is unreliable. Memory cues maintain recall of clinical information. This study provides evidence towards the requirement for standardisation of a structured patient handover. The use of memory cues (involving recognition memory and cued recall methodology) would be beneficial in a handover checklist to aid recall of clinical information and supports evidence for their adoption into clinical practice

Information erasure without an energy cost

Landauer argued that the process of erasing the information stored in a memory device incurs an energy cost in the form of a minimum amount of mechanical work. We find, however, that this energy cost can be reduced to zero by paying a cost in angular momentum or any other conserved quantity. Erasing the memory of Maxwell's demon in this way implies that work can be extracted from a single thermal reservoir at a cost of angular momentum and an increase in total entropy. The implications of this for the second law of thermodynamics are assessed.Comment: 8 pages with 1 figure. Final published versio

The cost to see the Wizard: buy-ins and trade-offs in neurological rehabilitation

This scientific commentary refers to ‘A decision-neuroscientific intervention to improve cognitive recovery after stroke’ by Studer et al. (doi:10.1093/brain/awab128)

Relations between Entropies Produced in Nondeterministic Thermodynamic Processes

Landauer's erasure principle is generalized to nondeterministic processes on systems having an arbitrary number of non-symmetrical logical states. The condition that the process is applied in the same way, irrespective of the initial logical state, imposes some restrictions on the individual heat exchanges associated with each possible transition. The complete set of such restrictions are derived by a statistical analysis of the phase-space flow induced by the process. Landauer's erasure principle can be derived from and is a special case of these.Comment: 12 pages with one figure; a final major revision in presentation; physical assumptions are clarified no

Rethinking damaged cognition: an expert opinion on cognitive rehabilitation

Cognition is frequently damaged by acquired brain injury (ABI). Impaired thinking is both a symptom in its own right and also a barrier to recovery by impacting their insight and awareness and their engagement with rehabilitation. Here we consider the aims, mechanisms and contexts when the goal is to improve cognitive function in patients with ABI

An expert opinion in speech and language therapy: The Queen Square Intensive Comprehensive Aphasia Programme

Less is more, right? Wrong: more is more. Here we make the case that the total dose of speech and language therapy (SLT) is a key factor in improving persons with aphasia’s (PWA) outcomes. The challenge is: how can we deliver high-dose therapy when resources are stretched? We review the recent evidence for dose and timing of SLT and then describe one solution to the problem of dose that we are trialing at Queen Square, an Intensive Comprehensive Aphasia Programme (ICAP)

Energy Requirement of Control: Comments on Szilard's Engine and Maxwell's Demon

In mathematical physical analyses of Szilard's engine and Maxwell's demon, a general assumption (explicit or implicit) is that one can neglect the energy needed for relocating the piston in Szilard's engine and for driving the trap door in Maxwell's demon. If this basic assumption is wrong, then the conclusions of a vast literature on the implications of the Second Law of Thermodynamics and of Landauer's erasure theorem are incorrect too. Our analyses of the fundamental information physical aspects of various type of control within Szilard's engine and Maxwell's demon indicate that the entropy production due to the necessary generation of information yield much greater energy dissipation than the energy Szilard's engine is able to produce even if all sources of dissipation in the rest of these demons (due to measurement, decision, memory, etc) are neglected.Comment: New, simpler and more fundamental approach utilizing the physical meaning of control-information and the related entropy production. Criticism of recent experiments adde

Hamiltonian Derivations of the Generalized Jarzynski Equalities under Feedback Control

In the presence of feedback control by "Maxwell's demon," the second law of thermodynamics and the nonequilibrium equalities such as the Jarzynski equality need to be generalized. In this paper, we derive the generalized Jarzynski equalities for classical Hamiltonian dynamics based on the Liouville's theorem, which is the same approach as the original proof of the Jarzynski equality [Phys. Rev. Lett. 78, 2690 (1997)]. The obtained equalities lead to the generalizations of the second law of thermodynamics for the Hamiltonian systems in the presence of feedback control.Comment: Proceedings of "STATPHYS - Kolkata VII", November 26-30, 2010, Kolkata, Indi

Dissipation: The phase-space perspective

We show, through a refinement of the work theorem, that the average dissipation, upon perturbing a Hamiltonian system arbitrarily far out of equilibrium in a transition between two canonical equilibrium states, is exactly given by $= -\Delta F =kT D(\rho\|\widetilde{\rho})= kT$, where $\rho$ and $\widetilde{\rho}$ are the phase space density of the system measured at the same intermediate but otherwise arbitrary point in time, for the forward and backward process. $D(\rho\|\widetilde{\rho})$ is the relative entropy of $\rho$ versus $\widetilde{\rho}$. This result also implies general inequalities, which are significantly more accurate than the second law and include, as a special case, the celebrated Landauer principle on the dissipation involved in irreversible computations.Comment: 4 pages, 3 figures (4 figure files), accepted for PR