A geometric construction of the exceptional Lie algebras F4 and E8

We present a geometric construction of the exceptional Lie algebras F4 and E8 starting from the round 8- and 15-spheres, respectively, inspired by the construction of the Killing superalgebra of a supersymmetric supergravity background. (There is no supergravity in the paper.)Comment: 12 page

Linear programming control of a group of heat pumps

For a new district in the Dutch city Meppel, a hybrid energy concept is developed based on bio-gas co-generation. The generated electricity is used to power domestic heat pumps which supply thermal energy for domestic hot water and space heating demand of households. In this paper, we investigate direct control of the heat pumps by the utility and how the large-scale optimization problem that is created can be reduced significantly. Two different linear programming control methods (global MILP and time scale MILP) are presented. The latter solves large-scale optimization problems in considerably less computational time. For simulation purposes, data of household thermal demand is obtained from prediction models developed for this research. The control methods are compared with a reference control method resembling PI on/off control of each heat pump. The reference control results in a dynamic electricity consumption with many peak loads on the network, which indicates a high level of simultaneous running heat pumps at those times. Both methods of mix integer linear programming (MILP) control of the heat pumps lead to a much improved, almost flat electricity consumption profile. Both optimization control methods are equally able to minimize the maximum peak consumption of electric power by the heat pumps, but the time scale MILP method requires much less computational effort. Future work is dedicated on further development of optimized control of the heat pumps and the central CHP

Upscaling a district heating system based on biogas cogeneration and heat pumps

The energy supply of the Meppel district Nieuwveense landen is based on biogas cogeneration, district heating, and ground source heat pumps. A centrally located combined heat and power engine (CHP) converts biogas from the municipal wastewater treatment facility into electricity for heat pumps and heat for district heating purposes. Development of the urban district is influenced by the current economic and building decline. For the district heating energy concept, a migration strategy for the required infrastructure is required. The migration spans the district’s small-scale starting phase involving 40 houses up to a scale of 176 houses. An optimization model which maximizes profitability is developed which includes data from district heating and cooling demand patterns. With the optimization model, optimal CHP size, boiler size, and operational hours are determined for various scenarios. From the scenario analysis, a migration strategy is developed which starts with a simple system concept supported by boilers to a larger system which includes a CHP. Sustainability in terms of CO2 emission savings of the energy concept is compared with other possible energy concepts

Molecular misreading: The occurrence of frameshift proteins in different diseases

Neuronal homoeostasis requires a constant balance between biosynthetic and catabolic processes. Eukaryotic cells primarily use two distinct mechanisms for degradation: the proteasome and autophagy of aggregates by the lysosomes. We focused on the UPS (ubiquitin-proteasome system). As a result of molecular misreading, misframed UBB (ubiquitin B) (UBB+1) is generated. UBB+1 accumulates in the neuritic plaques and neurofibrillary tangles in all patients with AD (Alzheimer's disease) and in the neuronal and glial hallmarks of other tauopathies and in polyglutamine diseases such as Huntington's disease. UBB+1 is not present in synucleinopathies such as Parkinson's disease. We showed that UBB+1 causes UPS dysfunction, aggregation and apoptotic cell death. UBB+1 is also present in non-neurological cells, hepatocytes of the diseased liver and in muscles during inclusion body myositis. Other frequently occurring (age-related) diseases such as Type 2 (non-insulin-dependent) diabetes mellitus are currently under investigation. These findings point to the importance of the UPS in diseases and open new avenues for target identification of the main players of the UPS. Treatment of these diseases with tools (e.g. viral RNA interference constructs) to intervene with specific targets is the next step

The effect of sublethal doses NaNO3 given in concentrates or by capsules on blood and vitamin A status of young red and white female cattle.

Administration of 0, 75, 150, 225 or 300 mg/kg body wt daily of NO3 as aqueous soln of NaNO3, mixed with the concentrate ration, to young heifers for a period of four months did not produce any serious toxic symptoms. In animals given 225 or 300 mg/kg there was, however, a slight reduction in feed consumption, along with increases in water intake, PCV values and conversion of Hb (up to 7%) into methaemoglobin. Respiration rate, body weight and vitamin A content of the liver were not affected. The toxicity of NaNO3 is discussed in relation to NO3 poisoning of cattle in the field. (Abstract retrieved from CAB Abstracts by CABI’s permission

Optical biopsy of epithelial cancers by optical coherence tomography

Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study aims to summarize the principles of OCT and to discuss the current literature on the diagnostic value of OCT in the diagnosis of epithelial (pre)malignant lesions. The authors did a systematic search of the electronic databases PubMed and Embase on OCT in the diagnostic process of (pre)malignant epithelial lesions. OCT is able to differentiate between benign and (pre)malignant lesions of epithelial origin in a wide variety of tissues. In this way, OCT can detect skin cancers, oral, laryngeal, and esophageal cancer as well as genital and bladder cancer. OCT is an innovative technique which enables an optical biopsy of epithelial lesions. The incorporation of OCT in specific tools, like handheld and catheter-based probes, will further improve the implementation of this technology in daily clinical practice

The influence of different Ca and P supplies on the vitamin A, Cu and Mn status of young cattle with additional effects of growth and season.

Six 9-month-old female Dutch Friesian cattle were given hay and pelleted concentrates with added 130 g CaCO3 or 100 g Na2HPO4 daily for periods of 50 days each. The supplements did not significantly influence growth or vitamin A, Cu or Mn in liver or blood plasma, although more P tended to retard growth. Liver vitamin A, Cu and Mn generally decreased significantly with time. Cu was more closely related to growth than vitamin A or Mn. A fall of Cu in blood plasma and liver was associated with a fall in the vitamin A in liver and with an increase of vitamin A in plasma.-V. J. B. (Abstract retrieved from CAB Abstracts by CABI’s permission

Diffusion in a generalized Rubinstein-Duke model of electrophoresis with kinematic disorder

Using a generalized Rubinstein-Duke model we prove rigorously that kinematic disorder leaves the prediction of standard reptation theory for the scaling of the diffusion constant in the limit for long polymer chains $D \propto L^{-2}$ unaffected. Based on an analytical calculation as well as Monte Carlo simulations we predict kinematic disorder to affect the center of mass diffusion constant of an entangled polymer in the limit for long chains by the same factor as single particle diffusion in a random barrier model.Comment: 29 pages, 3 figures, submitted to PR

Vasopressinergic modulation of stress responses in the central amygdala of the Roman high-avoidance and low-avoidance rat

The central nucleus of the amygdala (CEA) is selectively involved in the passive component of the behavioral (immobility) and the accompanying parasympathetic response during conditioned, stressful environmental challenges. Vasopressinergic mechanisms in the brain seem to play a role in these stress responses. The effects of the neuropeptides arginine-8-vasopressin (AVP) and oxytocin (OXT) on modulating CEA activity during conditioned stress of inescapable footshock were studied in male Roman high-avoidance (RHA/Verh) and low-avoidance (RLA/Verh) rats, psychogenetically selected on the basis of shuttle-box acquisition behavior. In RLA/Verh rats, the cardiac and behavioral responses to the conditioned emotional stressor were bradycardia and immobility, suggesting an important role for the CEA in these rats. The RHA/Verh rats, however, failed to show any change in heart rate or immobility in response to a conditioned stress situation. The low dose of AVP (20 pg) in the CEA of conscious RLA/Verh rats caused an enhancement of the stress-induced bradycardiac and immobility response. However, the high dose of AVP (2 ng) and OXT (200 pg) attenuated the bradycardiac and immobility responses in the RLA/Verh rats. Infusion of AVP and OXT in the RHA/Verh rats failed to induce any change in heart rate nr immobility. Binding studies revealed that the AVP receptor selectively binds AVP with high affinity. In contrast, the OXT receptor recognizes both AVP and OXT with a similar (but lower) affinity. This suggests that the behavioral and autonomic responses of the high dose of AVP may be caused by OXT receptor stimulation. In conclusion, on the basis of the present results one may hypothesize that CEA differences in AVP and OXT innervation and/or receptor densities may contribute to the differences in coping strategy found in these animals.

The heritability of HbA1c and fasting blood glucose in different measurement settings.

In an extended twin study we estimated the heritability of fasting HbA1c and blood glucose levels. Blood glucose was assessed in different settings (at home and in the clinic). We tested whether the genetic factors influencing fasting blood glucose levels overlapped with those influencing HbA1c and whether the same genetic factors were expressed across different settings. Fasting blood glucose was measured at home and during two visits to the clinic in 77 healthy families with same-sex twins and siblings, aged 20 to 45 years. HbA1c was measured during the first clinic visit. A 4-variate genetic structural equation model was used that estimated the heritability of each trait and the genetic correlations among traits. Heritability explained 75% of the variance in HbA1c. The heritability of fasting blood glucose was estimated at 66% at home and lower in the clinic (57% and 38%). Fasting blood glucose levels were significantly correlated across settings (0.34 < r < 0.54), mostly due to a common set of genes that explained between 53% and 95% of these correlations. Correlations between HbA1c and fasting blood glucoses were low (0.11 < r < 0.23) and genetic factors influencing HbA1c and fasting glucose were uncorrelated. These results suggest that in healthy adults the genes influencing HbA1c and fasting blood glucose reflect different aspects of the glucose metabolism. As a consequence these two glycemic parameters can not be used interchangeably in diagnostic procedures or in studies attempting to find genes for diabetes. Both contribute unique (genetic) information