Non-separable Gabor schemes : their design and implementation

vi+164hlm.;24c

Device and method for extracting information from characteristic signals

The present invention relates to a device and a method for extracting information from detected characteristic signals. A data stream (76, 78, 80, 82) derivable from electromagnetic radiation (14) emitted or reflected by an object (11) is received and a plurality of characteristic index elements (50) varying over time can be extracted therefrom. The index elements (50) comprise physiological information (48) indicative of at least one at least partially periodic vital signal (12), and a disturbing signal component (58). For eliminating the disturbing signal component (58) to a great extent, the characteristic index elements (50) can be projected to a disturbance-reduced index element (64) having a distinct orientation in relation to a presumed orientation of the disturbing signal component (58). The disturbance-reduced index element (64) is chosen so as to reflect a dominant main orientation and length of the disturbing signal component (58) over time. Consequently, the mainly genuine physiological information (48) extracted from the data stream (76, 78, 80, 82) in this way can be utilized for determining the at least one at least partially periodic vital signal (12)

Video coding and decoding devices and methods preserving PPG relevant information

The present invention relates to a video encoding device (10, 10', 10") and method for encoding video data and to a corresponding video decoding device (60, 60') and method. To preserve PPG relevant information after encoding without requiring a large amount of additional data for the video encoder output stream, the proposed video encoding device comprises a selection unit (20, 20') for selecting in input video data (100) skin areas as one or more regions of interest (101), that can be used to provide a strong PPG signal, based on one or more predetermined selection criteria including the spatial size, temporal stability, illumination stability and/or color stability or based on the quality and/or content of PPG signals extracted from skin areas potentially usable as region of interest,, a first encoding unit (30,30') for encoding said one or more regions of interest (101) of said input video data (100) according to a predetermined encoding scheme with a first setting of the encoding to preserve PPG-relevant information in the encoded one or more regions of interest, wherein said first encoding unit (30) is adapted for encoding only the chrominance components (101a) of said one or more regions of interest (101) or for encoding said one or more regions of interest (101) by intra-block coding,, a second encoding unit (40, 40') for encoding remaining parts (103) of said input video data (100) according to said predetermined encoding scheme with a second setting of the encoding, and an encoder combination unit (50) for combining the encoded one or more regions of interest (102) and the encoded remaining parts (104) of said input video data into an encoder output video stream (105).</p

Video coding and decoding devices and methods preserving ppg relevant information

The present invention relates to a video encoding device (10) for encoding video data and a corresponding video decoding device, wherein during decoding PPG relevant information shall be preserved. For this purpose the video coding device (10) comprises a first encoder (20) for encoding input video data (100) according to a first encoding scheme and outputting first coded video data (120) having a lower quality than the input video data, and a second encoder (30) for encoding input video data (100) according to a second encoding scheme preserving PPG-relevant information and outputting second coded video data (130)

A Systematic Evaluation of Cost-Saving Dosing Regimens for Therapeutic Antibodies and Antibody-Drug Conjugates for the Treatment of Lung Cancer

Background: Expensive novel anticancer drugs put a serious strain on healthcare budgets, and the associated drug expenses limit access to life-saving treatments worldwide. Objective: We aimed to develop alternative dosing regimens to reduce drug expenses. Methods: We developed alternative dosing regimens for the following monoclonal antibodies used for the treatment of lung cancer: amivantamab, atezolizumab, bevacizumab, durvalumab, ipilimumab, nivolumab, pembrolizumab, and ramucirumab; and for the antibody-drug conjugate trastuzumab deruxtecan. The alternative dosing regimens were developed by means of modeling and simulation based on the population pharmacokinetic models developed by the license holders. They were based on weight bands and the administration of complete vials to limit drug wastage. The resulting dosing regimens were developed to comply with criteria used by regulatory authorities for in silico dose development. Results: We found that alternative dosing regimens could result in cost savings that range from 11 to 28%, and lead to equivalent pharmacokinetic exposure with no relevant increases in variability in exposure. Conclusions: Dosing regimens based on weight bands and the use of complete vials to reduce drug wastage result in less expenses while maintaining equivalent exposure. The level of evidence of our proposal is the same as accepted by regulatory authorities for the approval of alternative dosing regimens of other monoclonal antibodies in oncology. The proposed alternative dosing regimens can, therefore, be directly implemented in clinical practice.</p