Finite-Amplitude Instability of the Compressible Laminar Wake. Strongly Amplified Disturbances

The interaction between mean flow and finite‐amplitude disturbances in certain experimentally observed unstable, compressible laminar wakes is considered theoretically without explicitly assuming small amplification rates. Boundary‐layer form of the two‐dimensional mean‐flow momentum, kinetic energy and thermal energy equations and the time‐averaged kinetic energy equation of spatially growing disturbances are recast into their respective von Kármán integral form which show the over‐all physical coupling. The Reynolds shear stresses couple the mean flow and disturbance kinetic energies through the conversion mechanism familiar in low‐speed flows. Both the mean flow and disturbance kinetic energies are coupled to the mean‐flow thermal energy through their respective viscous dissipation. The work done by the disturbance pressure gradients gives rise to an additional coupling between the disturbance kinetic energy and the mean‐flow thermal energy. The compressibility transformation suggested by work on turbulent shear flows is not applicable to this problem because of the accompanying ad hoc assumptions about the disturbance behavior. The disturbances of a discrete frequency which corresponds to the most unstable fundamental component, are first evaluated locally. Subsequent mean‐flow and disturbance profile‐shape assumptions are made in terms of a mean‐flow‐density Howarth variable. The compressibility transformation, which cannot convert this problem into a form identical to the low‐speed problem of Ko, Kubota, and Lees because of the compressible disturbance quantities, nevertheless, yields a much simplified description of the mean flow

Teaching Spoken English at Junior High School: A Comparison of TPR and PPP

This article reports on an experimental methods-comparison study, which was undertaken with beginner level junior high school students (aged 12 and 13) in Japan. The study aimed to investigate which type of teaching, Total Physical Response (TPR) or Present Practice Produce (PPP), was more effective in developing productive and receptive knowledge of a set of collocations. Results showed that both types of teaching had a significant impact upon the development of understanding and using the target language. However, there were no significant differences between the effectiveness of TPR and PPP, apart from a short-term benefit for PPP in terms of receptive knowledge. This shows that both types of teaching can have a positive impact upon learners of this age and level and that there is a need for further research to investigate the effectiveness of these communicative methodologies in this context

Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA)

<p><b>Background and Purpose:</b> Thrombolysis for acute ischemic stroke in patients aged >80 years is not approved in some countries due to limited trial data in the very elderly. We compared outcomes between thrombolysed and nonthrombolysed (control) patients from neuroprotection trials to assess any influence of age on response.</p> <p><b>Method:</b>Among patients with ischemic stroke of known age, pretreatment severity (baseline National Institutes of Health Scale Score), and 90-day outcome (modified Rankin Scale score; National Institutes of Health Scale score), we compared the distribution of modified Rankin score in thrombolysed patients with control subjects by Cochran-Mantel-Haenszel test and then logistic regression after adjustment for age and baseline National Institutes of Health Scale score. We examined patients ≤80 and ≥ 81 years separately and then each age decile.</p> <p><b>Results:</b> Rankin data were available for 5817 patients, 1585 thrombolysed and 4232 control subjects; 20.5% were aged >80 years (mean ± SD, 85.1 ± 3.4 years). Baseline severity was higher among thrombolysed than control subjects (median National Institutes of Health Scale score 14 versus 13, P<0.05). The distribution of modified Rankin Scale scores was better among thrombolysed patients (P<0.0001; OR, 1.39; 95% CI, 1.26 to 1.54). The association occurred independently with similar magnitude among young (P<0.0001; OR, 1.42; 95% CI, 1.26 to 1.59) and elderly (P=0.002; OR, 1.34; 95% CI, 1.05 to 1.70) patients. ORs were consistent across all age deciles >30 years; outcomes assessed by National Institutes of Health Scale score gave supporting significant findings, and dichotomized modified Rankin Scale score outcomes were also consistent.</p> <p><b>Conclusions:</b> Outcome after thrombolysis for acute ischemic stroke was significantly better than in control subjects. Despite the expected poorer outcomes among elderly compared with young patients that is independent of any treatment effect, the association between thrombolysis treatment and improved outcome is maintained in the very elderly. Age alone should not be a barrier to treatment.</p&gt

Mind, Brain, and Education: A Case Study of Student Perceptions of an Interdisciplinary Graduate Program

Advances in developmental and neuroscience research, calls for educational reform, and an emphasis on interdisciplinarity have generated interest in how science might inform educational practice and policy, resulting in the emerging field of mind, brain, and education (MBE). A primary goal of the field is to connect the cognitive and developmental sciences, biology, and education to develop a scientific grounding for educational practice and policy. Interdisciplinary MBE graduate programs seek to train a new generation of interdisciplinary researchers and practitioners. The purpose of this case study is to investigate students’ perceptions of their experiences developing interdisciplinary understanding in an MBE graduate program; how these perceptions vary based on student characteristics; and, to explore student perceptions of the potential and limitations of MBE to address educational problems. The findings suggest students gain interdisciplinary knowledge and skills in the program; are able to synthesize and produce integrative understandings to apply to problems in education; and, that the MBE program positively affects their appreciation for interdisciplinary research and their readiness to collaborate on interdisciplinary research. The results suggest students perceive the diversity of the knowledge, skills, and backgrounds of the cohort and participation in a lab/research experience are among the most supportive aspects of their experience in interdisciplinary learning and understanding, as well as in their future interdisciplinary work. Students leave having thought critically about a wide variety of tensions, uncertainties, and power imbalances in the interdisciplinary work of MBE and feel prepared to participate in collaborative research and begin the slow, and significant, process of change to improve education. The study is unique in exploring student perceptions of an MBE program and contributes to the literature on students’ development of interdisciplinary understanding and on educators’ beliefs about the potential of MBE to influence educational practice and policy. The study offers insight to institutions and individuals interested in developing interdisciplinary programs to advance the field of MBE and address some of the complex issues facing education today

Cognitive/decisional Predictors Of Coping Propensity And Stress Arousal: Validation Of A Choice/control Schema

Although stress investigators have intimated that decisional processes comprise important precursors to coping activity, there have been few attempts, within the stress domain, to conceptualize coping behaviour in the context of stress-relevant decisional models. In the present dissertation, an attempt was made to evaluate Neufeld\u27s (1982) choice/control model. This model, which was derived from subjective expected utility theory, makes three interrelated hypotheses regarding the determinants of coping propensity and anticipatory stress arousal. Hypothesis One states that the propensity to engage in counterstress activity will be an inverse function of the ratio of the expected value of stress, given counterstress activity, to the expected value of stress, given no counterstress activity. Hypothesis Two states that anticipatory stress arousal primarily will be a function of the lowest of the latter numerator or denominator components. Hypothesis Three states that anticipatory stress arousal will increase, due to decisional uncertainty, as the value of the cost-of-coping ratio approaches one.;The model was evaluated in the context of four interrelated studies. Three studies involved the analysis of self-report judgments of stress and one study involved the analysis of cognitive, behavioural, and psychophysiological indicators of stress. Together, study results provided strong and stable support for Neufeld\u27s (1982) choice/control model across different experimental contexts and different response modalities. Results also revealed three types of stressor situations in which model-relevant hypotheses were not consistently supported. These included (a) challenging situations and situations outside the threat domain; (b) situations characterized by the juxtaposition of incompatible response tendencies; and (c) situations characterized by impact uncertainty . An examination of the conditions under which choice/control hypotheses were not supported suggested that future investigations should be concerned with: (a) the perceptual versus mathematical distinction between the cost-of-coping ratio components; (b) the influence on choice behaviour of changes in stress expectancy judgments over time; and (c) the potentially different components of global stress expectancy judgments and their implications for the variable meaning of the latter. Even in the absence of such investigations, it is argued the model has strong heuristic value in its current, unmodified form

Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study

Background: Phylogenetic reconstruction is a necessary first step in many analyses which use whole genome sequence data from bacterial populations. There are many available methods to infer phylogenies, and these have various advantages and disadvantages, but few unbiased comparisons of the range of approaches have been made. Methods: We simulated data from a defined "true tree" using a realistic evolutionary model. We built phylogenies from this data using a range of methods, and compared reconstructed trees to the true tree using two measures, noting the computational time needed for different phylogenetic reconstructions. We also used real data from Streptococcus pneumoniae alignments to compare individual core gene trees to a core genome tree. Results: We found that, as expected, maximum likelihood trees from good quality alignments were the most accurate, but also the most computationally intensive. Using less accurate phylogenetic reconstruction methods, we were able to obtain results of comparable accuracy; we found that approximate results can rapidly be obtained using genetic distance based methods. In real data we found that highly conserved core genes, such as those involved in translation, gave an inaccurate tree topology, whereas genes involved in recombination events gave inaccurate branch lengths. We also show a tree-of-trees, relating the results of different phylogenetic reconstructions to each other. Conclusions: We recommend three approaches, depending on requirements for accuracy and computational time. Quicker approaches that do not perform full maximum likelihood optimisation may be useful for many analyses requiring a phylogeny, as generating a high quality input alignment is likely to be the major limiting factor of accurate tree topology. We have publicly released our simulated data and code to enable further comparisons

Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial

<p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke. The xanthine oxidase inhibitor allopurinol lowers uric acid but also attenuates expression of inflammatory adhesion molecules in murine models, reduces oxidative stress in the vasculature, and improves endothelial function. We sought to investigate whether allopurinol alters expression of inflammatory markers after acute ischemic stroke.</p> <p><b>Methods</b>: We performed a randomized, double-blind, placebo-controlled trial to investigate the safety, tolerability, and effect of 6 weeks’ treatment with high- (300 mg once a day) or low- (100 mg once a day) dose allopurinol on levels of uric acid and circulating inflammatory markers after ischemic stroke.</p> <p><b>Results</b>: We enrolled 50 patients with acute ischemic stroke (17, 17, and 16 in the high, low, and placebo groups, respectively). Mean (±SD) age was 70 (±13) years. Groups had similar characteristics at baseline. There were no serious adverse events. Uric acid levels were significantly reduced at both 7 days and 6 weeks in the high-dose group (by 0.14 mmol/L at 6 weeks, P=0.002). Intercellular adhesion molecule-1 concentration (ng/mL) rose by 51.2 in the placebo group, rose slightly (by 10.6) in the low-dose allopurinol group, but fell in the high-dose group (by 2.6; difference between groups P=0.012, Kruskal-Wallis test).</p> <p><b>Conclusion</b>: Allopurinol treatment is well tolerated and attenuates the rise in intercellular adhesion molecule-1 levels seen after stroke. Uric acid levels were lowered with high doses. These findings support further evaluation of allopurinol as a preventive measure after stroke.</p&gt

Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats

<p><b>Background and Purpose:</b> The study aim was to assess the effects of magnesium sulfate (MgSO4) administration on white matter damage in vivo in spontaneously hypertensive rats.</p> <p><b>Methods:</b> The left internal capsule was lesioned by a local injection of endothelin-1 (ET-1; 200 pmol) in adult spontaneously hypertensive rats. MgSO4 was administered (300 mg/kg SC) 30 minutes before injection of ET-1, plus 200 mg/kg every hour thereafter for 4 hours. Infarct size was measured by T2-weighted magnetic resonance imaging (day 2) and histology (day 11), and functional recovery was assessed on days 3 and 10 by the cylinder and walking-ladder tests.</p> <p><b>Results:</b> ET-1 application induced a small, localized lesion within the internal capsule. Despite reducing blood pressure, MgSO4 did not significantly influence infarct volume (by magnetic resonance imaging: median, 2.1 mm3; interquartile range, 1.3 to 3.8, vs 1.6 mm3 and 1.2 to 2.1, for the vehicle-treated group; by histology: 0.3 mm3 and 0.2 to 0.9 vs 0.3 mm3 and 0.2 to 0.5, respectively). Significant forelimb and hindlimb motor deficits were evident in the vehicle-treated group as late as day 10. These impairments were significantly ameliorated by MgSO4 in both cylinder (left forelimb use, P<0.01 and both-forelimb use, P<0.03 vs vehicle) and walking-ladder (right hindlimb score, P<0.02 vs vehicle) tests.</p> <p><b>Conclusions:</b> ET-1–induced internal capsule ischemia in spontaneously hypertensive rats represents a good model of lacunar infarct with small lesion size, minimal adverse effects, and a measurable motor deficit. Despite inducing mild hypotension, MgSO4 did not significantly influence infarct size but reduced motor deficits, supporting its potential utility for the treatment of lacunar infarct.</p&gt

Statistical analysis of the primary outcome in acute stroke trials

Common outcome scales in acute stroke trials are ordered categorical or pseudocontinuous in structure but most have been analyzed as binary measures. The use of fixed dichotomous analysis of ordered categorical outcomes after stroke (such as the modified Rankin Scale) is rarely the most statistically efficient approach and usually requires a larger sample size to demonstrate efficacy than other approaches. Preferred statistical approaches include sliding dichotomous, ordinal, or continuous analyses. Because there is no best approach that will work for all acute stroke trials, it is vital that studies are designed with a full understanding of the type of patients to be enrolled (in particular their case mix, which will be critically dependent on their age and severity), the potential mechanism by which the intervention works (ie, will it tend to move all patients somewhat, or some patients a lot, and is a common hazard present), a realistic assessment of the likely effect size, and therefore the necessary sample size, and an understanding of what the intervention will cost if implemented in clinical practice. If these approaches are followed, then the risk of missing useful treatment effects for acute stroke will diminish