Putting 'M' back in Monetary Policy

Money demand and the stock of money have all but disappeared from monetary policy analyses. This paper is an empirical contribution to the debate over the role of money in monetary policy analysis. The paper models supply and demand interactions in the money market and finds evidence of an essential role for money in the transmission of policy. Across sub-samples, it finds evidence consistent with the following inferences: (1) the money stock and the interest rate jointly transmit monetary policy; (2) for a given exogenous change in the nominal interest rate, the estimated impact of policy on economic activity increases monotonically with the response of the money supply; (3) the path of the real rate is not sufficient for determining policy impacts.

Control of Glycolytic Flux by AMPK and p53-mediated Signaling Pathways in Tumor Cells Grown at Low pH

Introduction: Tumor cells grow in nutrient and oxygen deprived microenvironments and adapt to the suboptimal growth conditions by altering metabolic pathways. This adaptation process characteristically results in a tumor phenotype that displays upregulated Hif-1α anaerobic glycolysis, chronic acidification, reduced rate of overall protein synthesis, lower rate of cell proliferation and aggressive invasive characteristics. Most transplantable tumors exhibit a pHe of 6.7- 7.0; the DB-1 melanoma xenografts used here have a pHe=6.7. Understanding tumor cell reaction to the microenvironment is a critical factor in predicting the tumor response to radiotherapy. The glucose regulatory molecule, 6-Phosphofructo-2-Kinase/Fructose-2,6- Biphosphatase Isoform-3 (PFKFB3), is a bifunctional enzyme central to glycolytic flux and downstream of the metabolic stress sensor AMP-activated protein kinase (AMPK), which we show activates an isoform of phosphofructokinase (PFK-2). Radiation Research Society (RRS) 8th Annual Meeting September 25-29, Maui, H

Control of Glycolytic Flux by AMPK and p53-Mediated Signaling Pathways in Tumor Cells Adapted to Grow at Low pH

Introduction: Tumor cells grow in nutrient and oxygen deprived microenvironments and adapt to the suboptimal growth conditions by altering metabolic pathways. This adaptation process characteristically results in a tumor phenotype that displays anaerobic glycolysis, chronic acidification and aggressive tumor characteristics. Understanding the tumor cell reaction to the microenvironment is a critical factor in predicting the tumor response to hyperthermia. The glucose regulatory molecule, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase Isoform-3 (PFKFB3), is a bifunctional enzyme central to glycolytic flux and downstream of the metabolic stress sensor AMP-activated protein kinase (AMPK), which has been shown to activate an isoform of Phosphofructokinase (PFK-2). Society for Thermal Medicine Annual Meeting April 23-26, Clearwater Beach, FL

Asymmetric radiating brane-world

At high energies on a cosmological brane of Randall-Sundrum type, particle interactions can produce gravitons that are emitted into the bulk and that can feed a bulk black hole. We generalize previous investigations of such radiating brane-worlds by allowing for a breaking of Z_2-symmetry, via different bulk cosmological constants and different initial black hole masses on either side of the brane. One of the notable features of asymmetry is a suppression of the asymptotic level of dark radiation, which means that nucleosynthesis constraints are easier to satisfy. There are also models where the radiation escapes to infinity on one or both sides, rather than falling into a black hole, but these models can have negative energy density on the brane.Comment: sign error in eq. (34) corrected; version to appear Phys. Rev.

The GUCY2C Tumor Suppressor is the Nexus of a Paracrine Hormone Axis Preventing Radiotherapy-Induced Gastrointestinal (GI) Toxicity

Purpose/Objective: Radiation-induced GI toxicity is the primary dose limitation compromising therapy in cancer patients treated with radiation therapy. GUCY2C is the intestinal receptor for diarrheagenic bacterial enterotoxins and the endogenous paracrine hormones guanylin and uroguanylin. Following genomic insult, cyclic (c)GMP produced by ligand activation of GUCY2C enhances DNA damage sensing and repair in intestinal cells. Here, we show that the GUCY2C-cGMP axis mediates p53-dependent radioprotection of intestinal epithelial cells. American Society for Therapeutic Radiation Oncology (ASTRO) 52nd Annual Meeting October 31 - November 4, San Diego, C

President Trump’s inaugural address: USAPP experts react

On Friday January 20th, 2017, Donald J. Trump was sworn in as the 45th President of the United States. We asked USAPP’s expert contributors to give their rapid reaction to President Trump’s inaugural address

Long-term culture of human breast cancer specimens and their analysis using optical projection tomography

Breast cancer is a leading cause of mortality in the Western world. It is well established that the spread of breast cancer, first locally and later distally, is a major factor in patient prognosis. Experimental systems of breast cancer rely on cell lines usually derived from primary tumours or pleural effusions. Two major obstacles hinder this research: (i) some known sub-types of breast cancers (notably poor prognosis luminal B tumours) are not represented within current line collections; (ii) the influence of the tumour microenvironment is not usually taken into account. We demonstrate a technique to culture primary breast cancer specimens of all sub-types. This is achieved by using three-dimensional (3D) culture system in which small pieces of tumour are embedded in soft rat collagen I cushions. Within 2-3 weeks, the tumour cells spread into the collagen and form various structures similar to those observed in human tumours1. Viable adipocytes, epithelial cells and fibroblasts within the original core were evident on histology. Malignant epithelial cells with squamoid morphology were demonstrated invading into the surrounding collagen. Nuclear pleomorphism was evident within these cells, along with mitotic figures and apoptotic bodies. We have employed Optical Projection Tomography (OPT), a 3D imaging technology, in order to quantify the extent of tumour spread in culture. We have used OPT to measure the bulk volume of the tumour culture, a parameter routinely measured during the neo-adjuvant treatment of breast cancer patients to assess response to drug therapy. Here, we present an opportunity to culture human breast tumours without sub-type bias and quantify the spread of those ex vivo. This method could be used in the future to quantify drug sensitivity in original tumour. This may provide a more predictive model than currently used cell lines.Publisher PDFPeer reviewe

Hot dense capsule implosion cores produced by z-pinch dynamic hohlraum radiation

Hot dense capsule implosions driven by z-pinch x-rays have been measured for the first time. A ~220 eV dynamic hohlraum imploded 1.7-2.1 mm diameter gas-filled CH capsules which absorbed up to ~20 kJ of x-rays. Argon tracer atom spectra were used to measure the Te~ 1keV electron temperature and the ne ~ 1-4 x10^23 cm-3 electron density. Spectra from multiple directions provide core symmetry estimates. Computer simulations agree well with the peak compression values of Te, ne, and symmetry, indicating reasonable understanding of the hohlraum and implosion physics.Comment: submitted to Phys. Rev. Let

Degeneracy of consistency equations in braneworld inflation

In a Randall-Sundrum type II inflationary scenario we compute perturbation amplitudes and spectral indices up to next-to-lowest order in the slow-roll parameters, starting from the well-known lowest-order result for a de Sitter brane. Using two different prescriptions for the tensor amplitude, we show that the braneworld consistency equations are not degenerate with respect to the standard relations and we explore their observational consequences. It is then shown that, while the degeneracy between high- and low-energy regimes can come from suitable values of the cosmological observables, exact functional matching between consistency expressions is plausibly discarded. This result is then extended to the Gauss-Bonnet case.Comment: 16 pages, 3 figures. v3: major revision. Changed title, updated references, rearranged material, new prescription for the tensor spectrum, new figures, extended and more robust conclusion

Holography and Brane-bulk Energy Exchange

The five-dimensional description of generalized Randall-Sundrum cosmology is mapped via holography to a generalization of the Starobinsky model. This provides a holographic dual description of the cosmological brane-bulk energy exchange processes studied previously. Some simple solutions are presented in four dimensions.Comment: 41 pages, LaTe