Clinical characteristics of the study participants.

<p>The data are presented as mean ± SD. BMI: Body Mass Index. HbA_1c: haemoglobin A_1c. HDL: high density lipoprotein. LDL: low density lipoprotein. T2D: type 2 diabetes.</p

Effect of <i>KCNQ1</i> variants rs151290, rs2237892 and rs2237895 on beta-cell function as assessed with hyperglycaemic clamp.

a<p>Adjusted for glucose tolerance status (NGT/IGT), study center, age, gender and BMI.</p><p>All variables were log-transformed before analysis. <i>p</i>-values were computed for different additive models using linear generalized estimating equations (GEE) which takes into account the family relatedness when computing the standard errors. Alleles in bold are the risk alleles for type 2 diabetes identified by previous studies.</p><p>DI, disposition index; IGT, impaired glucose tolerance; ISI, insulin sensitivity index; ND, not determined; NGT, normal glucose tolerance.</p

Effect of <i>KCNQ1</i> variants rs151290, rs2237892 and rs2237895 on quantitative metabolic traits in non-diabetic individuals.

a<p>Adjusted for age, sex and study center.</p>b<p>p-value for the additive model.</p><p>The data are presented as mean±SD. All variables were log-transformed before analysis. Alleles in bold are the risk alleles for type 2 diabetes identified by previous studies. BMI: Body Mass Index. HbA_1c: haemoglobin A_1c (glucose bound to haemoglobin). HDL: high density lipoprotein. LDL: low density lipoprotein.</p

Association of the <i>KCNQ1</i> variants with type 2 diabetes in the Dutch population.

a<p>Adjusted for age, sex and study center.</p>b<p>p-value for the additive model.</p><p>For each variant the C-allele is the risk allele for type 2 diabetes as identified by previous studies. RAF: risk allele frequency. T2D: type 2 diabetes.</p