1,170 research outputs found
The fibered isomorphism conjecture for complex manifolds
In this paper we show that the fibered isomorphism conjecture of Farrell and
Jones corresponding to the stable topological pseudoisotopy functor is true for
the fundamental groups of a large class of complex manifolds. A consequence of
this result is that the Whitehead group, reduced projective class groups and
the negative K-groups of the fundamental group of these manifolds vanish
whenever the fundamental group is torsion free. We also prove the same results
for a class of real manifolds.Comment: accepted for publication in Acta Mathematica Sinica, English Serie
A de novo variant in the keratin 1 gene (KRT1) in a Chinese shar-pei dog with severe congenital cornification disorder and non-epidermolytic ichthyosis.
A 3-months old Chinese shar-pei puppy with ichthyosis was investigated. The dog showed generalized scaling, alopecia and footpad lesions. Histopathological examinations demonstrated a non-epidermolytic hyperkeratosis. The parents of the affected puppy did not show any skin lesions. A trio whole genome sequencing analysis identified a heterozygous de novo 3 bp deletion in the KRT1 gene in the affected dog. This variant, NM_001003392.1:c.567_569del, is predicted to delete a single asparagine from the conserved coil 1A motif within the rod domain of KRT1, NP_001003392.1:p.(Asn190del). Immunohistochemistry demonstrated normal levels of KRT1 expression in the epidermis and follicular epithelia. This might indicate that the variant possibly interferes with keratin dimerization or another function of KRT1. Missense variants affecting the homologous asparagine residue of the human KRT1 cause epidermolytic hyperkeratosis. Histologically, the investigated Chinese shar-pei showed a non-epidermolytic ichthyosis. The finding of a de novo variant in an excellent functional candidate gene strongly suggests that KRT1:p.Asn190del caused the ichthyosis phenotype in the affected Chinese shar-pei. To the best of our knowledge, this is the first description of a KRT1-related non-epidermolytic ichthyosis in domestic animals
Generalized Sagnac Effect
Experiments were conducted to study light propagation in a light waveguide
loop consisting of linearly and circularly moving segments. We found that any
segment of the loop contributes to the total phase difference between two
counterpropagating light beams in the loop. The contribution is proportional to
a product of the moving velocity v and the projection of the segment length
Deltal on the moving direction, Deltaphi=4pivDeltal/clambda. It is independent
of the type of motion and the refractive index of waveguides. The finding
includes the Sagnac effect of rotation as a special case and suggests a new
fiber optic sensor for measuring linear motion with nanoscale sensitivity.Comment: 3 pages (including 3 figures
Probing Spin-Polarized Currents in the Quantum Hall Regime
An experiment to probe spin-polarized currents in the quantum Hall regime is
suggested that takes advantage of the large Zeeman-splitting in the
paramagnetic diluted magnetic semiconductor zinc manganese selenide
(ZnMnSe). In the proposed experiment spin-polarized electrons are
injected by ZnMnSe-contacts into a gallium arsenide (GaAs) two-dimensional
electron gas (2DEG) arranged in a Hall bar geometry. We calculated the
resulting Hall resistance for this experimental setup within the framework of
the Landauer-B\"uttiker formalism. These calculations predict for 100%
spininjection through the ZnMnSe-contacts a Hall resistance twice as high as in
the case of no spin-polarized injection of charge carriers into a 2DEG for
filling factor . We also investigated the influence of the equilibration
of the spin-polarized electrons within the 2DEG on the Hall resistance. In
addition, in our model we expect no coupling between the contact and the 2DEG
for odd filling factors of the 2DEG for 100% spininjection, because of the
opposite sign of the g-factors of ZnMnSe and GaAs.Comment: 7 pages, 5 figure
Synthesizing efficacious genistein in conjugation with superparamagnetic Fe<sub>3</sub>O<sub>4</sub> decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma
Stabilisation of single longitudinal mode operation in a Q-switched Nd:YAG laser
Detection of the reflected laser beam power from the mode-selecting etalon in a prelase-Q-switched laser provides an indicator of mode-frequency drifts. The detected signal can be used to control a piezo-mounted resonator mirror, thus correcting the drift and providing a means for maintaining single longitudinal mode operation on every shot
Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34 -> q36 by fluorescence in situ hybridization and radiation hybrid mapping
We have cloned the complete coding region of the porcine TNFSF10 gene. The porcine TNFSF10 cDNA has an ORF of 870 nucleotides and shares 85 % identity with human TNFSF10, and 75% and 72% identity with rat and mouse Tnfsf10 coding sequences, respectively. The deduced porcine TNFSF10 protein consists of 289 amino acids with the calculated molecular mass of 33.5 kDa and a predicted pI of 8.15. The amino acid sequence similarities correspond to 86, 72 and 70% when compared with human, rat and mouse sequences, respectively. Nor-them blot analysis detected TNFSF10-specific transcripts (similar to 1.7 kb) in various organs of a 10-week-old pig, suggesting ubiquitous expression. Real-time RT-PCR studies of various organs from fetal (days 73 and 98) and postnatal stages (two weeks, eight months) demonstrated developmental and tissue-specific regulation of TNFSF10 mRNA abundance. The chromosomal location of the porcine TNFSF10 gene was determined by FISH of a specific BAC clone to metaphase chromosomes. This TNFSF10 BAC clone has been assigned to SSC13q34 -> q36. Additionally, the localization of the TNFSF10 gene was verified by RH mapping on the porcine IMpRH panel. Copyright (c) 2005S. KargerAG, Basel
Detecting unambiguously non-Abelian geometric phases with trapped ions
We propose for the first time an experimentally feasible scheme to disclose
the noncommutative effects induced by a light-induced non-Abelian gauge
structure with trapped ions. Under an appropriate configuration, a true
non-Abelian gauge potential naturally arises in connection with the geometric
phase associated with two degenerated dark states in a four-state atomic system
interacting with three pulsed laser fields. We show that the population in
atomic state at the end of a composed path formed by two closed loops and
in the parameter space can be significantly different from the composed
counter-ordered path. This population difference is directly induced by the
noncommutative feature of non-Abelian geometric phases and can be detected
unambiguously with current technology.Comment: 6 page
Farmer groups for animal health and welfare planning in European organic dairy herds
A set of common principles for active animal health and welfare planning in organic dairy farming has been developed in the ANIPLAN project group of seven European countries. Health and welfare planning is a farmer‐owned process of continuous development and improvement and may be practised in many different ways. It should incorporate health promotion and disease handling, based on a strategy where assessment of current status and risks forms the basis for evaluation, action and review. Besides this, it should be 1) farm-specific, 2) involve external person(s) and 3) external knowledge, 4) be based on organic principles, 5) be written, and 6) acknowledge good aspects in addition to targeting the problem areas in order to stimulate the learning process. Establishing farmer groups seems to be a beneficial way of stimulating a dynamic development on the farms towards continuous improvement, as in this case with focus on animal health and welfare planning. Various factors influence the process in different contexts, e.g. geographical, cultural, traditional factors, and a proper analysis of the situation as well as the purpose of the group is necessary, and can relevantly be negotiated and co‐developed with farmers as well as facilitators before being implemented. Farmer groups based on farmer‐to‐farmer advice and co‐development need a facilitator who takes on the role of facilitating the process and ‘decodes’ him‐ or herself from being ‘expert’
SOAT1 missense variant in two cats with sebaceous gland dysplasia.
Spontaneously arisen hereditary diseases in domestic animals provide an excellent opportunity to study the physiological functions of the altered genes. We investigated two 4-month-old sibling domestic short haired kittens with dry dark debris around the eyes, nose, and ears, dark crusting on the legs and a thin poor hair coat. Skin biopsies revealed abnormal sebaceous gland morphology with lack of normal sebocyte arrangement and differentiation. Hair follicles had a distorted silhouette, interpreted as a change secondary to the observed sebaceous gland dysplasia. Whole genome sequencing on both affected kittens and 65 genetically diverse feline genomes was performed. Filtering for variants that were present in both kittens but absent from the control genomes revealed a homozygous missense variant in SOAT1, encoding sterol O-acyltransferase 1. The protein is localized in the endoplasmic reticulum and catalyzes the formation of cholesteryl esters, an essential component of sebum and meibum. The identified SOAT1:c.1531G > A variant is predicted to change a highly conserved glycine residue within the last transmembrane domain of SOAT1, p.Gly511Arg. In mice, variants in Soat1 or complete knockout of the gene lead to the "hair interior defect" (hid) or abnormal Meibomian glands, respectively. SOAT1:c.1531G > A represents a plausible candidate variant for the observed sebaceous gland dysplasia in both kittens of this study. The variant was not present in 10 additional cats with a similar clinical and histopathological phenotype suggesting genetic heterogeneity. SOAT1 variants should be considered as potential cause in hereditary sebaceous gland dysplasias of humans and domestic animals
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