7,675 research outputs found
Comparison of Support Vector Machine and Back Propagation Neural Network in Evaluating the Enterprise Financial Distress
Recently, applying the novel data mining techniques for evaluating enterprise
financial distress has received much research alternation. Support Vector
Machine (SVM) and back propagation neural (BPN) network has been applied
successfully in many areas with excellent generalization results, such as rule
extraction, classification and evaluation. In this paper, a model based on SVM
with Gaussian RBF kernel is proposed here for enterprise financial distress
evaluation. BPN network is considered one of the simplest and are most general
methods used for supervised training of multilayered neural network. The
comparative results show that through the difference between the performance
measures is marginal; SVM gives higher precision and lower error rates.Comment: 13 pages, 1 figur
On Stochastic Subgradient Mirror-Descent Algorithm with Weighted Averaging
This paper considers stochastic subgradient mirror-descent method for solving
constrained convex minimization problems. In particular, a stochastic
subgradient mirror-descent method with weighted iterate-averaging is
investigated and its per-iterate convergence rate is analyzed. The novel part
of the approach is in the choice of weights that are used to construct the
averages. Through the use of these weighted averages, we show that the known
optimal rates can be obtained with simpler algorithms than those currently
existing in the literature. Specifically, by suitably choosing the stepsize
values, one can obtain the rate of the order for strongly convex
functions, and the rate for general convex functions (not
necessarily differentiable). Furthermore, for the latter case, it is shown that
a stochastic subgradient mirror-descent with iterate averaging converges (along
a subsequence) to an optimal solution, almost surely, even with the stepsize of
the form , which was not previously known. The stepsize choices
that achieve the best rates are those proposed by Paul Tseng for acceleration
of proximal gradient methods
Streamlines for Motion Planning in Underwater Currents
Motion planning for underwater vehicles must consider the effect of ocean
currents. We present an efficient method to compute reachability and cost
between sample points in sampling-based motion planning that supports
long-range planning over hundreds of kilometres in complicated flows. The idea
is to search a reduced space of control inputs that consists of stream
functions whose level sets, or streamlines, optimally connect two given points.
Such stream functions are generated by superimposing a control input onto the
underlying current flow. A streamline represents the resulting path that a
vehicle would follow as it is carried along by the current given that control
input. We provide rigorous analysis that shows how our method avoids exhaustive
search of the control space, and demonstrate simulated examples in complicated
flows including a traversal along the east coast of Australia, using actual
current predictions, between Sydney and Brisbane.Comment: 7 pages, 4 figures, accepted to IEEE ICRA 2019. Copyright 2019 IEE
Receptor oligomerization: from early evidence to current understanding in class B GPCRs
Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.published_or_final_versio
Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus
The evolutionary trajectories of growth hormone-releasing hormone (GHRH) receptor remain enigmatic since the discovery of physiologically functional GHRH-GHRH receptor (GHRHR) in non-mammalian vertebrates in 2007. Interestingly, subsequent studies have described the identification of a GHRHR2 in chicken in addition to the GHRHR and the closely related paralogous receptor, PACAP-related peptide (PRP) receptor (PRPR). In this article, we provide information, for the first time, on the GHRHR in sarcopterygian fish and amphibians by the cloning and characterization of GHRHRs from lungfish (P. dolloi) and X. laevis. Sequence alignment and phylogenetic analyses demonstrated structural resemblance of lungfish GHRHR to their mammalian orthologs, while the X. laevis GHRHR showed the highest homology to GHRHR2 in zebrafish and chicken. Functionally, lungfish GHRHR displayed high affinity towards GHRH in triggering intracellular cAMP and calcium accumulation, while X. laevis GHRHR2 was able to react with both endogenous GHRH and PRP. Tissue distribution analyses showed that both lungfish GHRHR and X. laevis GHRHR2 had the highest expression in brain, and interestingly, X. laevis GHRHR2 also had high abundance in the reproductive organs. These findings, together with previous reports, suggest that early in the Sarcopterygii lineage, GHRHR and PRPR have already established diverged and specific affinities towards their cognate ligands. GHRHR2, which has only been found in xenopus, zebrafish and chicken hitherto, accommodates both GHRH and PRP.published_or_final_versio
Serdexmethylphenidate/Dexmethylphenidate – A Promising Treatment Option for Childhood Attention Deficit Hyperactivity Disorder (ADHD)
To review the phase 2 and phase 3 clinical trials of Serdexmethylphenidate and dexmethylphenidate (SDX/d-MPH) in the treatment of Attention Deficit/Hyperactivity disorder (ADHD) in children
Design of the freeform V-cut optics in the cell phone backlight system
2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
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