Array CGH based identification of amplified chromosome 8p11.23-11.22 region encompassing ADAM9 gene.

<p>Array CGH based identification of amplified chromosome 8p11.23-11.22 region encompassing ADAM9 gene.</p

Array CGH based identification of amplified chromosome 7q34 region encompassing MGAM gene.

<p>Array CGH based identification of amplified chromosome 7q34 region encompassing MGAM gene.</p

Socio-demographic and clinic-pathologic parameters of 46 OSCC patients.

<p>Socio-demographic and clinic-pathologic parameters of 46 OSCC patients.</p

The ideogram of top most frequently CNAs in term of amplifcations and deletions identified in this study using aCGH.

<p>The ideogram of top most frequently CNAs in term of amplifcations and deletions identified in this study using aCGH.</p

Amplification of ADAM5P, MGAM and SIRPB1 identifed by using aCGH and qPCR in OSCC samples.

<p>The percentage for amplification of ADAM5P were almost similar from aCGH and qPCR study with 80% (37/46 OSCC samples) and 81.25% (39/48 OSCC samples), respectively. Similarly, the percentage of the amplification detected from aCGH and qPCR for MGAM gene were also reported as 74% (37/46 OSCC samples) and 50% (24/48 OSCC samples), respectively. The percentage of amplification identified from aCGH and qPCR for SIRPB1 were 61% (28/46 OSCC samples) and 25% (12/48 OSCC samples).</p

The gene expression level (RQ) of MGAM and ADAM9 in OSCC samples.

<p>The gene expression level (RQ) of MGAM and ADAM9 in OSCC samples based on the fold change which expressed as an average of 30 OSCC samples. In OSCC, MGAM has the highest gene expression level (RQ = 6.6) where the gene expression between OSCC and normal mucosa is statistically significant (p = 0.001). This is followed by ADAM9 with gene expression level of RQ = 1.51 (p = 0.093). The RQ for normal tissue (NT) of the two genes were 1 due to the normalization.</p