2,554 research outputs found
Nondestructive Testing Potential of a Magnetoacoustic Storage Correlator (MASC)
A simple magnetoacoustic storage correlator (MASC) was tested as a pulse compressor in an ultrasonic nondestructive testing application. The pulse compression ratio reached was 30. Higher compression ratios are readily available through choice of different device lengths and device operating regime. The system is flexible; it is not limited to any particular type of large time-bandwidth signal. The correlator reference signal is easily programmable and erasable, and can be changed at any time. This system offers real-time correlation signal processing at a repetition rate that is only limited by the temporal length of the large time-bandwidth signal
Combustion in thermonuclear supernova explosions
Type Ia supernovae are associated with thermonuclear explosions of white
dwarf stars. Combustion processes convert material in nuclear reactions and
release the energy required to explode the stars. At the same time, they
produce the radioactive species that power radiation and give rise to the
formation of the observables. Therefore, the physical mechanism of the
combustion processes, as reviewed here, is the key to understand these
astrophysical events. Theory establishes two distinct modes of propagation for
combustion fronts: subsonic deflagrations and supersonic detonations. Both are
assumed to play an important role in thermonuclear supernovae. The physical
nature and theoretical models of deflagrations and detonations are discussed
together with numerical implementations. A particular challenge arises due to
the wide range of spatial scales involved in these phenomena. Neither the
combustion waves nor their interaction with fluid flow and instabilities can be
directly resolved in simulations. Substantial modeling effort is required to
consistently capture such effects and the corresponding techniques are
discussed in detail. They form the basis of modern multidimensional
hydrodynamical simulations of thermonuclear supernova explosions. The problem
of deflagration-to-detonation transitions in thermonuclear supernova explosions
is briefly mentioned.Comment: Author version of chapter for 'Handbook of Supernovae,' edited by A.
Alsabti and P. Murdin, Springer. 24 pages, 4 figure
Global financial crisis and job satisfaction of atypical workers : the case of Taiwan
Author name used in this publication: Bih-Hearn Virginia LeeAuthor name used in this publication: David Fu-Keung Ip2010-2011 > Academic research: not refereed > Publication in policy or professional journalAccepted ManuscriptPublishe
新世代行動主義之全球化
2011-2012 > Academic research: refereed > Refereed conference paperVersion of RecordPublishe
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells
Translation of ribosomal protein-coding mRNAs (RP-mRNAs) constitutes a key step in ribosome biogenesis, but the mechanisms that modulate RP-mRNA translation in coordination with other cellular processes are poorly defined. Here, we show that subcellular localization of RP-mRNAs acts as a key regulator of their translation during cell migration. As cells migrate into their surroundings, RP-mRNAs localize to the actin-rich cell protrusions. This localization is mediated by La-related protein 6 (LARP6), an RNA-binding protein that is enriched in protrusions. Protrusions act as hotspots of translation for RP-mRNAs, enhancing RP synthesis, ribosome biogenesis, and the overall protein synthesis in migratory cells. In human breast carcinomas, epithelial-to-mesenchymal transition (EMT) upregulates LARP6 expression to enhance protein synthesis and support invasive growth. Our findings reveal LARP6-mediated mRNA localization as a key regulator of ribosome biogenesis during cell migration and demonstrate a role for this process in cancer progression downstream of EMT
Dementia and risk of visual impairment in Chinese older adults
We had previously identified visual impairment increasing risk of incident dementia. While a bi-directional vision-cognition association has subsequently been proposed, no study has specifically examined the longitudinal association between dementia and incidence of clinically defined visual impairment. In this territory-wide community cohort study of 10,806 visually unimpaired older adults, we examined their visual acuity annually for 6 years and tested if dementia at baseline was independently associated with higher risk of incident visual impairment (LogMAR ≥ 0.50 in the better eye despite best correction, which is equivalent to moderate visual impairment according to the World Health Organization definition). By the end of Year 6, a total of 3151 (29.2%) participants developed visual impairment. However, we did not find baseline dementia associating with higher risk of incident visual impairment, after controlling for baseline visual acuity, cataract, glaucoma, diabetes, hypertension, hypercholesterolemia, heart diseases, stroke, Parkinson's disease, depression, hearing and physical impairments, physical, intellectual and social activities, diet, smoking, age, sex, educational level, and socioeconomic status. Among different covariables, baseline visual acuity appears to be more important than dementia in contributing to the development of visual impairment. Our present findings highlight the need for re-evaluating whether dementia is indeed a risk factor for visual impairment
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LES investigation into the generation of momentum deficits in the supersonic wake of a micro-ramp
Implicitly implemented large eddy simulation (LES) with a fifth-order WENO scheme was conducted in this study. Based on Navier-Stokes equations, this LES was carried out to explore the origin of momentum deficit caused by a supersonic micro-ramp at flow conditions of M a = 2.5 and Re θ = 5760. The numerical results were validated through qualitative and quantitative comparisons with existing experimental data. After describing the aerodynamic properties of the supersonic wake, such as the deficit and the streamwise vortices, the momentum deficit was later detected to originate from the lower portion of the upstream boundary layer, while the high momentum fluid originated from close to the wall at the upper portion. Position alternation trigged by the micro-ramp was finally proposed as a revised mechanism
A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits
The small EDRK-rich factor 2 (SERF2) is a highly conserved protein that modifies amyloid fibre assembly in vitro and promotes protein misfolding. However, the role of SERF2 in regulating age-related proteotoxicity remains largely unexplored due to a lack of in vivo models. Here, we report the generation of Serf2 knockout mice using an ES cell targeting approach, with Serf2 knockout alleles being bred onto different defined genetic backgrounds. We highlight phenotyping data from heterozygous Serf2^{+/-} mice, including unexpected male-specific phenotypes in startle response and pre-pulse inhibition. We report embryonic lethality in Serf2^{-/-} null animals when bred onto a C57BL/6 N background. However, homozygous null animals were viable on a mixed genetic background and, remarkably, developed without obvious abnormalities. The Serf2 knockout mice provide a powerful tool to further investigate the role of SERF2 protein in previously unexplored pathophysiological pathways in the context of a whole organism
Accreting Neutron Stars in Low-Mass X-Ray Binary Systems
Using the Rossi X-ray Timing Explorer (RossiXTE), astronomers have discovered
that disk-accreting neutron stars with weak magnetic fields produce three
distinct types of high-frequency X-ray oscillations. These oscillations are
powered by release of the binding energy of matter falling into the strong
gravitational field of the star or by the sudden nuclear burning of matter that
has accumulated in the outermost layers of the star. The frequencies of the
oscillations reflect the orbital frequencies of gas deep in the gravitational
field of the star and/or the spin frequency of the star. These oscillations can
therefore be used to explore fundamental physics, such as strong-field gravity
and the properties of matter under extreme conditions, and important
astrophysical questions, such as the formation and evolution of millisecond
pulsars. Observations using RossiXTE have shown that some two dozen neutron
stars in low-mass X-ray binary systems have the spin rates and magnetic fields
required to become millisecond radio-emitting pulsars when accretion ceases,
but that few have spin rates above about 600 Hz. The properties of these stars
show that the paucity of spin rates greater than 600 Hz is due in part to the
magnetic braking component of the accretion torque and to the limited amount of
angular momentum that can be accreted in such systems. Further study will show
whether braking by gravitational radiation is also a factor. Analysis of the
kilohertz oscillations has provided the first evidence for the existence of the
innermost stable circular orbit around dense relativistic stars that is
predicted by strong-field general relativity. It has also greatly narrowed the
possible descriptions of ultradense matter.Comment: 22 pages, 7 figures, updated list of sources and references, to
appear in "Short-period Binary Stars: Observation, Analyses, and Results",
eds. E.F. Milone, D.A. Leahy, and D. Hobill (Dordrecht: Springer,
http://www.springerlink.com
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