Western Australia and the evolving regional order: challenges and opportunities

Executive Summary: 21st century Asia is a powerhouse in the contemporary global economy. In a short period of time it has closed the development gap between the Region and the rest of the world. All indications suggest that this growth performance will continue into the foreseeable future.Australia’s high levels of economic growth over the last decade are directly related to Asia’s ‘economic miracle,’ with Western Australia playing a lead role in Australia’s regional economic engagement. Indeed, the State has accounted for nearly 50 per cent of Australia’s commodity export trade in recent years, concentrated overwhelmingly in Asia. In this sense Australia, and Western Australia in particular, are becoming increasingly ‘hard wired’ into the Region. This presents many opportunities but also challenges.The First Murdoch Commission was established to identify how these opportunities may be pursued and how the challenges may be addressed. The initial impetus was that future prosperity required well-informed strategies and policy settings to optimise potential benefits and sustainable gains.The broad context of the inquiry was the contemporary rise of Asia. This rise is a story of success, yet it is success accompanied by significant challenges. Deepening regional integration is an essential part of the story, with the effect of distributing risks as well as benefits. The ongoing performance of the Region is thus also a question about addressing major problems including rapid urbanisation, resources security, demographic burdens and environmental pressures.This insight underpinned the deliberations of the Commission and its investigation of how economic engagement and the growing interdependency of Western Australia, Australia and the Region can be pursued to enhance mutual benefit and long-term resilience.A distinct feature of the Commission’s investigations was its regional approach. This included the composition of the Commission’s membership, and a series of meetings and consultations with various stakeholder groups and individuals in major regional centres. This approach was taken precisely because Australia’s core interests are now closely intertwined with Asia’s continuing prosperity and stability.The Commission found that there is a strategic choice to be taken by Australia: whether to remain a mere exporter to the Region or to become a more active participant engaging in the Region. The former choice leaves Australia susceptible to the volatilities of a game that it has little capacity to influence. By contrast, the latter offers Australia far greater potential influence, opportunity and long-term benefit for its economic prosperity and wider future. Efforts in this space should not underestimate the major challenges confronting both the Region and the Australian economy, and how regional cooperation can provide ways to address these challenges.Western Australia provided a fertile case for the Commission to examine regional opportunities and challenges from the standpoint of a sub-national unit. There is potential for Western Australia to develop a more prominent role in the Region, and the Commission identified various possibilities at hand.The Commission concluded that greater regional engagement offered many benefits. This includes opportunities for Australia to contribute to addressing some of the major challenges in the Region, especially in areas such as food security and capacity building. Western Australia in particular has a lot to offer and a lot to gain in this respect

Continuous measurements of real-life bidirectional pedestrian flows on a wide walkway

Employing partially overlapping overhead \kinectTMS sensors and automatic pedestrian tracking algorithms we recorded the crowd traffic in a rectilinear section of the main walkway of Eindhoven train station on a 24/7 basis. Beside giving access to the train platforms (it passes underneath the railways), the walkway plays an important connection role in the city. Several crowding scenarios occur during the day, including high- and low-density dynamics in uni- and bi-directional regimes. In this paper we discuss our recording technique and we illustrate preliminary data analyses. Via fundamental diagrams-like representations we report pedestrian velocities and fluxes vs. pedestrian density. Considering the density range $0$ - $1.1\,$ped/m$^2$, we find that at densities lower than $0.8\,$ped/m$^2$ pedestrians in unidirectional flows walk faster than in bidirectional regimes. On the opposite, velocities and fluxes for even bidirectional flows are higher above $0.8\,$ped/m$^2$.Comment: 9 pages, 7 figure

Inertial particle acceleration in strained turbulence

The dynamics of inertial particles in turbulence is modelled and investigated by means of direct numerical simulation of an axisymmetrically expanding homogeneous turbulent strained flow. This flow can mimic the dynamics of particles close to stagnation points. The influence of mean straining flow is explored by varying the dimensionless strain rate parameter $Sk_0/\epsilon_0$ from 0.2 to 20. We report results relative to the acceleration variances and probability density functions for both passive and inertial particles. A high mean strain is found to have a significant effect on the acceleration variance both directly, through an increase in wave number magnitude, and indirectly, through the coupling of the fluctuating velocity and the mean flow field. The influence of the strain on normalized particle acceleration pdfs is more subtle. For the case of passive particle we can approximate the acceleration variance with the aid of rapid distortion theory and obtain good agreement with simulation data. For the case of inertial particles we can write a formal expressions for the accelerations. The magnitude changes in the inertial particle acceleration variance and the effect on the probability density function are then discussed in a wider context for comparable flows, where the effects of the mean flow geometry and of the anisotropy at the small scales are present

Bioactive Scaffolds Integrated with Liposomal or Extracellular Vesicles for Bone Regeneration

With population aging and increased life expectancy, an increasing number of people are facing musculoskeletal health problems that necessitate therapeutic intervention at defect sites. Bone tissue engineering (BTE) has become a promising approach for bone graft substitutes as traditional treatments using autografts or allografts involve clinical complications. Significant advancements have been made in developing ideal BTE scaffolds that can integrate bioactive molecules promoting robust bone repair. Herein, we review bioactive scaffolds tuned for local bone regenerative therapy, particularly through integrating synthetic liposomal vesicles or extracellular vesicles to the scaffolds. Liposomes offer an excellent drug delivery system providing sustained release of the loaded bioactive molecules. Extracellular vesicles, with their inherent capacity to carry bioactive molecules, are emerging as an advanced substitute of synthetic nanoparticles and a novel cell-free therapy for bone regeneration. We discuss the recent advance in the use of synthetic liposomes and extracellular vesicles as bioactive materials combined with scaffolds, highlighting major challenges and opportunities for their applications in bone regeneration. We put a particular focus on strategies to integrate vesicles to various biomaterial scaffolds and introduce the latest advances in achieving sustained release of bioactive molecules from the vesicle-loaded scaffolds at the bone defect site

Molecular Gas Content of HI Monsters and Implications to Cold Gas Content Evolution in Galaxies

We present 12CO (J=1-0) observations of a sample of local galaxies (0.04<z<0.08) with a large neutral hydrogen reservoir, or "HI monsters". The data were obtained using the Redshift Search Receiver on the FCRAO 14 m telescope. The sample consists of 20 HI-massive galaxies with M(HI)>3e10Msun from the ALFALFA survey and 8 LSBs with a comparable M(HI) (>1.5e10Msun). Our sample selection is purely based on the amount of neutral hydrogen, thereby providing a chance to study how atomic and molecular gas relate to each other in these HI-massive systems. We have detected CO in 15 out of 20 ALFALFA selected galaxies and 4 out of 8 LSBs with molecular gas mass M(H2) of (1-11)e9Msun. Their total cold gas masses of (2-7e10Msun make them some of the most gas-massive galaxies identified to date in the Local Universe. Observed trends associated with HI, H2, and stellar properties of the HI massive galaxies and the field comparison sample are analyzed in the context of theoretical models of galaxy cold gas content and evolution, and the importance of total gas content and improved recipes for handling spatially differentiated behaviors of disk and halo gas are identified as potential areas of improvement for the modeling.Comment: 18 pages, 11 figures, 2 tables; Accepted for publication in MNRA

Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndrome

PurposeTo investigate the efficacy of topiramate monotherapy in West syndrome prospectively.MethodsThe study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a maximum of 12 mg/kg/day. Clinical assessment was based on the parents' report and a neurological examination every 2 weeks for the first 2 months of treatment. The baseline electroencephalograms (EEGs) were compared with the post-treatment EEGs at 2 weeks and 1 month.ResultsWest syndrome was considered to be cryptogenic in 7 of the 28 patients and symptomatic in 21 patients. After treatment, 11 patients (39%) became spasm-free, 6 (21%) had more than 50% spasmsreduction, 3 (11%) showed less than 50% reduction, and 8 (29%) did not respond. The effective daily dose for achieving more than 50% reduction in spasm frequency, including becoming spasm-free, was found to be 5.8±1.1 mg/kg/day. Nine patients (32%) showed complete disappearance of spasms and hypsarrhythmia, and 11 (39%) showed improved EEG results. Despite adverse events (4 instances of irritability, 3 of drowsiness, and 1 of decreased feeding), no patients discontinued the medication.ConclusionTopiramate monotherapy seems to be effective and well tolerated as a first line therapy for West syndrome and is not associated with serious adverse effects

A Passivity-based Nonlinear Admittance Control with Application to Powered Upper-limb Control under Unknown Environmental Interactions

This paper presents an admittance controller based on the passivity theory for a powered upper-limb exoskeleton robot which is governed by the nonlinear equation of motion. Passivity allows us to include a human operator and environmental interaction in the control loop. The robot interacts with the human operator via F/T sensor and interacts with the environment mainly via end-effectors. Although the environmental interaction cannot be detected by any sensors (hence unknown), passivity allows us to have natural interaction. An analysis shows that the behavior of the actual system mimics that of a nominal model as the control gain goes to infinity, which implies that the proposed approach is an admittance controller. However, because the control gain cannot grow infinitely in practice, the performance limitation according to the achievable control gain is also analyzed. The result of this analysis indicates that the performance in the sense of infinite norm increases linearly with the control gain. In the experiments, the proposed properties were verified using 1 degree-of-freedom testbench, and an actual powered upper-limb exoskeleton was used to lift and maneuver the unknown payload.Comment: Accepted in IEEE/ASME Transactions on Mechatronics (T-MECH