Lack of spontaneous ocular neovascularization and attenuated laser-induced choroidal neovascularization in IGF-I overexpression transgenic mice

Robust IGF-I overexpression induces ocular angiogenesis in mice. To investigate the effect of subtle IGF-I overexpression, we examined the ocular phenotype of IGF-II promoter-driven IGF-I transgenic mice. Despite 2.5-fold elevation of IGF-I mRNA in the retina and 29 and 52% increase of IGF-I protein in the retina and aqueous humor, respectively, no ocular abnormality was observed in these transgenics. This was correlated with unaltered VEGF mRNA levels in the transgenic retina. The transgene was also associated with an attenuated laser-induced choroidal neovascularization. Differential expression levels and pattern of IGF-I gene may underlie the different retinal phenotypes in different transgenic lines

N-Ethyl-3,5-dinitro­benzamide

In the title mol­ecule, C9H9N3O5, the dihedral angle between the mean planes of the amide group and the benzene ring is 31.24 (14)°. In the crystal, N—H⋯O hydrogen bonds link the mol­ecules to form one-dimensional chains propagating in [100]

An Accelerating 3D Image Reconstruction System Based on the Level-of-Detail Algorithm

This paper proposes a research of An Accelerating 3D Image Reconstruction System Based on the Level-of-Detail Algorithm and combines 3D graphic application interfaces, such as DirectX3D and OpenCV to reconstruct the 3D imaging system for Magnetic Resonance Imaging (MRI), and adds Level of Detail (LOD) algorithm to the system. The system uses the volume rendering method to perform 3D reconstruction for brain imaging. The process, which is based on the level of detail algorithm that converts and formulates functions from differing levels of detail and scope, significantly reduces the complexity of required processing and computation, under the premises of maintaining drawing quality. To validate the system's efficiency enhancement on brain imaging reconstruction, this study operates the system on various computer platforms, and uses multiple sets of data to perform rendering and 3D object imaging reconstruction, the results of which are then verified and compared

Life table of Cochlochila bullita stål (hemiptera: tingidae) on Orthosiphon aristatus (blume) miq. and Ocimum basilicum l. in laboratory conditions

Ocimum tingid, Cochlochila bullita Stål (Hemiptera: Tingidae) is a pest of Lamiaceae plants such as basil, tulsi and coleus. It is now being recorded in Malaysia as a pest of the cat’s whiskers plant, Orthosiphon aristatus (Blume) Miq. Nevertheless, apart from its brief biological description, no other information is available. The life table of this pest was studied in laboratory conditions. Development time for C. bullita feeding on O. aristatus was 23.3 ± 0.9 days, which was found to be similar to those feeding on Ocimum basilicum (22.8 ± 0.3 days). Although C. bullita posts a higher mortality rate on O. aristatus than on O.basilicum (52% vs. 37%), the adult longevity of the bugs that feed on O. aristatus (♀: 33.9; ♂: 38.2 days) was found to be significantly higher than those bugs that feed on O.basilicum (♀: 27.2; ♂: 26.0 days). The pre-ovipostion, ovispostion and fecundity of C. bullita were also different between the host plants. The net reproductive rates (R0), finite rate of increase (λ) and intrinsic rate of increase (r) were also higher on O. aristatus (10.7504, 1.0690 and 0.0667), although there was an increased in immature survival on O. basilicum (6.0287, 1.0556 and 0.0541). Therefore, it is concluded that O. aristatus is as good as O. basilicum, or the population growth of C. bullita is more favoured as compared to O. basilicum

N,4-Dimethyl­benzamide

In the crystal of the title compound, C9H11NO, mol­ecules are connected via inter­molecular N—H⋯O hydrogen bonds, forming a one-dimensional network in the b-axis direction. The dihedral angle between the amide group and the benzyl ring is 13.8 (2)°

Health Information Science: 7th International Conference, HIS 2018, Cairns, QLD, Australia, October 5–7, 2018, Proceedings

[Extract] The International Conference Series on Health Information Science (HIS) provides a forum for disseminating and exchanging multidisciplinary research results in computer science/information technology and health science and services. It covers all aspects of health information sciences and systems that support health information management and health service delivery. The 7th International Conference on Health Information Science (HIS 2018) was held in Cairns, Queensland, Australia, during October 5–7, 2018. Founded in April 2012 as the International Conference on Health Information Science and Their Applications, the conference continues to grow to include an ever-broader scope of activities. The main goal of these events is to provide international scientific forums for researchers to exchange new ideas in a number of fields that interact in depth through discussions with their peers from around the world. The scope of the conference includes: (1) medical/health/biomedicine information resources, such as patient medical records, devices and equipments, software and tools to capture, store, retrieve, process, analyze, and optimize the use of information in the health domain; (2) data management, data mining, and knowledge discovery, all of which play a key role in decision-making, management of public health, examination of standards, privacy and security issues; (3) computer visualization and artificial intelligence for computer-aided diagnosis; and (4) development of new architectures and applications for health information systems

Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study

The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy. A total of 200 volunteers (65–79 years of age) scheduled for gastroscopy under anesthesia were randomly divided into the following groups: P, propofol (1.5–2.0 mg/kg); E, etomidate (0.15-0.2 mg/kg); P+E, propofol (0.75–1 mg/kg) followed by etomidate (0.075-0.1 mg/kg); and E+P, etomidate (0.075-0.01 mg/kg) followed by propofol (0.75–1 mg/kg). Vital signs and bispectral index were monitored at different time points. Complications, induction and examination time, anesthesia duration, and recovery and discharge time were recorded. At the end of the procedure, the satisfaction of patients, endoscopists and the anesthetist were evaluated. The recovery (6.1±1.2 h) and discharge times (24.8±2.8 h) in group E were significantly longer compared with groups P, P+E and E+P (P<0.05). The occurrence of injection pain in group P+E was significantly higher compared with the other three groups (P<0.05). In addition, the incidence of myoclonus and post-operative nausea and vomiting were significantly higher in group P+E compared with the other three groups (P<0.05). There was no statistical difference among the four groups with regards to the patients' immediate, post-procedure satisfaction (P>0.05). Furthermore, there was no difference in the satisfaction of anesthesia, as evaluated by the anesthetist and endoscopist, among the four groups (P>0.05). The present study demonstrates that anesthesia for gastroscopy in elderly patients can be safely and effectively accomplished using a drug regimen that combines propofol with etomidate. The combined use of propofol and etomidate has unique characteristics which improve hemodynamic stability, cause minimal respiratory depression and less side effects, provide rapid return to full activity and result in high levels of satisfaction

Production of low formaldehyde emission particleboard by using new formulated formaldehyde based resin

In order to preserve the global market competitiveness, the particleboard industry was affronted with challenges to reduce formaldehyde emission while maintaining the quality strength properties of particleboard. To counter the issue, particleboards with five different surface-to-core ratio were fabricated by applying newly formulated UF and MUF resins which were 30% surface: 70% core (3:7); 40% surface: 60% core (4:6); 50% surface: 50% core (5:5); 60% surface: 40% core (6:4) and 70% surface: 30% core (7:3) based on dry particle weight respectively. Formaldehyde emission and strength properties of the fabricated particleboard were investigated based on Japanese Industrial Standard, which are JIS A 1460 and JIS A 5908, respectively. All the MUF-bonded particleboard complied with the type 18 standard, whereas all the UF-bonded particleboard produced complied with type 13 except thickness swelling of the UF-bonded particleboard. The surface-to-core ratio applied in three layered particleboard for both resins exerted considerable influence on the strength properties and formaldehyde emission of particleboards produced from both resins. MUF-bonded particleboard with 40% surface and 60% core recorded the lowest formaldehyde emission (0.09 mg L-1) and highest strength properties. For UF-bonded particleboard, the ratio of 60% surface and 40% core showed the lowest formaldehyde emission (0.28 mg L-1) with better strength properties. This study highlighted the potential of MUF resin to replace UF resin due to its ability to produce F**** particleboard with better strength properties and lower formaldehyde emission according to JIS A 5908

Addition of propylamine as formaldehyde scavenger for urea formaldehyde-bonded particleboard

Rubberwood particleboard were produced using urea formaldehyde (UF) resin admixed with propylamine as formaldehyde scavenger. 1 % propylamine were incorporated into 8 %, 10 %, 12 %, 14 % and 16 % UF resins, respectively. The effectiveness of propylamine addition to reduce formaldehyde emission from particleboard was examined. Physical and mechanical properties were evaluated according to Japanese Industrial Standard (JIS). The results showed that addition of propylamine had reduced 33 to 65 % formaldehyde emission from particleboard made with different dosages of UF resin. However, the properties of the particleboard were adversely influenced by the addition of propylamine. Higher resin dosage (≥14 %) had counterbalanced the loss of strength and dimensional stability but accompanied by increased formaldehyde emission. As a conclusion, UF dosage of 14 % admixed with 1 % propylamine is the most ideal formulation to produce particleboard with low formaldehyde emission while maintaining the desired properties