How Pennsylvania has taken steps to address the cannabis industry’s equity problem

While cannabis decriminalization and legalization has grown across the states, the profits from cannabis-related businesses have tended to flow mainly to white men, raising issues of equity. In new research, Lee Hannah, Daniel Mallinson, and Lauren Azevedo evaluate measures introduced in Pennsylvania to improve equity in who benefits from cannabis sales

Maximizing Social Equity as a Pillar of Public Administration: An Examination of Cannabis Dispensary Licensing in Pennsylvania

Public administration upholds four pillars of an administrative practice: economy, efficiency, effectiveness, and social equity. The question arises, however, how do administrators balance effectiveness and social equity when implementing policy? Can the values contributing to administrative decisions be measured? This study leverages the expansion of medical cannabis programs in the states to interrogate these questions. The awarding of dispensary licenses in Pennsylvania affords the ability to determine the effect of social equity scoring on license award decisions, relative to criteria that represent the other pillars. The results show that safety and business acumen were the most important determining factors in the awarding of licenses, both effectiveness concerns. Social equity does not emerge as a significant determinant until the second round of licensing. This study then discusses the future of social equity provisions for cannabis policy, as well as what the findings mean for social equity in public administration

A synthetic, three-dimensional bone marrow hydrogel [preprint]

Three-dimensional (3D) synthetic hydrogels have recently emerged as desirable in vitro cell culture platforms capable of representing the extracellular geometry, elasticity, and water content of tissue in a tunable fashion. However, they are critically limited in their biological functionality. Hydrogels are typically decorated with a scant 1-3 peptide moieties to direct cell behavior, which vastly underrepresents the proteins found in the extracellular matrix (ECM) of real tissues. Further, peptides chosen are ubiquitous in ECM, and are not derived from specific proteins. We developed an approach to incorporate the protein complexity of specific tissues into the design of biomaterials, and created a hydrogel with the elasticity of marrow, and 20 marrow-specific cell-instructive peptides. Compared to generic PEG hydrogels, our marrow-inspired hydrogel improves stem cell differentiation and proliferation. We propose this tissue-centric approach as the next generation of 3D hydrogel design for applications in tissue engineering

Integrated Stellar Populations: Confronting Photometry with Spectroscopy

We investigate the ability of spectroscopic techniques to yield realistic star formation histories (SFHs) for the bulges of spiral galaxies based on a comparison with their observed broadband colors. Full spectrum fitting to optical spectra indicates that recent (within ~1 Gyr) star formation activity can contribute significantly to the V-band flux, whilst accounting for only a minor fraction of the stellar mass budget which is made up primarily of old stars. Furthermore, recent implementations of stellar population (SP) models reveal that the inclusion of a more complete treatment of the thermally pulsating asymptotic giant branch (TP-AGB) phase to SP models greatly increases the NIR flux for SPs of ages 0.2-2 Gyr. Comparing the optical--NIR colors predicted from population synthesis fitting, using models which do not include all stages of the TP-AGB phase, to the observed colors reveals that observed optical--NIR colors are too red compared to the model predictions. However, when a 1 Gyr SP from models including a full treatment the TP-AGB phase is used, the observed and predicted colors are in good agreement. This has strong implications for the interpretation of stellar populations, dust content, and SFHs derived from colors alone.Comment: 6 pages, 6 figures, accepted for publication in the Astrophysical Journa

Hypervelocity Star Candidates in the SEGUE G & K Dwarf Sample

We present 20 candidate hypervelocity stars from the Sloan Extension for Galactic Understanding and Exploration (SEGUE) G and K dwarf samples. Previous searches for hypervelocity stars have only focused on large radial velocities; in this study we also use proper motions to select the candidates. We determine the hypervelocity likelihood of each candidate by means of Monte Carlo simulations, considering the significant errors often associated with high proper motion stars. We find that nearly half of the candidates exceed their escape velocities with at least 98% probability. Every candidate also has less than a 25% chance of being a high-velocity fluke within the SEGUE sample. Based on orbits calculated using the observed six-dimensional positions and velocities, few, if any, of these candidates originate from the Galactic center. If these candidates are truly hypervelocity stars, they were not ejected by interactions with the Milky Way's supermassive black hole. This calls for a more serious examination of alternative hypervelocity-star ejection scenarios.Comment: 8 pages, 5 figures, published in ApJ, this version includes all figures as intende

Physical Activity for Adults with Visual Impairments: Impact of Socio-Demographic Factors

Little is known about what factors influence physical activity participation for adult-aged individuals with visual impairments. Therefore, the purpose of this study was to explore the impact of socio-demographic factors on the physical activity participation of adults with visual impairments. The international physical activity questionnaire-short form and a socio-demographic factor questionnaire were distributed to individuals with visual impairments. A total of 176 adults (Mage = 47.04, 52.8% female) completed the questionnaires. Physical activity and socio-demographic variables were analyzed descriptively and relationships were explored using correlation analysis and multiple regression analysis. On average, participants reported 413.79 minutes of moderate-to-vigorous physical activity and 2058.52 minutes of sedentary active per week. A significant amount of variance of physical activity was explained by the socio-demographic variables in this study. Of the socio-demographic variables measured, only gender emerges as a significant positive predictor of total weekly physical activity. The results of this study both affirm and conflict with previous research. Unlike previous research focusing on those with visual impairments, this study demonstrated that gender was an important predictor of physical activity. This finding is consistent with population-wide data on individuals without disabilities in the United States

Tracing the Origins and Evolution of Small Planets using Their Orbital Obliquities

We recommend an intensive effort to survey and understand the obliquity distribution of small close-in extrasolar planets over the coming decade. The orbital obliquities of exoplanets--i.e., the relative orientation between the planetary orbit and the stellar rotation--is a key tracer of how planets form and migrate. While the orbital obliquities of smaller planets are poorly explored today, a new generation of facilities coming online over the next decade will make such observations possible en masse. Transit spectroscopic observations with the extremely large telescopes will enable us to measure the orbital obliquities of planets as small as $\sim2R_{\oplus}$ around a wide variety of stars, opening a window into the orbital properties of the most common types of planets. This effort will directly contribute to understanding the formation and evolution of planetary systems, a key objective of the National Academy of Sciences' Exoplanet Science Strategies report.Comment: Submitted to the Astro2020 call for science white papers. 7 pages, 2 figure

Exploring Asian and Asian American Specific Body Mass Index Cut-Points

Background: Body Mass Index (BMI) is used as a quick and inexpensive tool to measure populations at risk for a number of metabolic and chronic conditions. In part due to its simplicity, BMI has been criticized for its inaccurate prediction concerning health outcomes. Due to the diversity in the United States, one of the potential remedies offered was to introduce race-based BMI cut-points to better predict the relationship between obesity, morbidity, and mortality. The purpose of this study was to explore Asian and Asian American specific BMI cut-points and its potential implications. Methods: A scoping review of the literature was conducted through PubMed. Qualitative content and thematic analyses were conducted. Results: Initial search resulted in twenty articles. Eleven studies met criteria for evaluation. Thematic analyses identified 1) Addressing disparities in morbidity and mortality 2) Lowering cut-points did not result in better clinical outcomes 3) Asian/Asian Americans are a multicultural, diverse group. Conclusion: The BMI cut-points should not be lowered for Asian or Asian Americans in the United States.Keywords: Asian and Asian American, BMI, Asian Specific BMI Cut-Point

Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care

We wish to save lives of patients admitted to ICUs. Their mortality is high enough based simply on the severity of the original injury or illness, but is further raised by events during their stay. We target those events that are subacute but potentially catastrophic, such as infection. Sepsis, for example, is a bacterial infection of the bloodstream, that is common in ICU patients and has a \u3e 25% risk of death. Logically, early detection and treatment with antibiotics should improve outcomes. Our fundamental precepts are (1) some potentially catastrophic medical and surgical illnesses have subclinical phases during which early diagnosis and treatment might have life-saving effects, (2) these phases are characterized by changes in the normal highly complex but highly adaptive regulation and interaction of the nervous system and other organs such as the heart and lungs, (3) teams of clinicians and quantitative scientists can work together to identify clinically important abnormalities of monitoring data, to develop algorithms that match the clinicians\u27 eye in detecting abnormalities, and to undertake the clinical trials to test their impact on outcomes

The Effects of a High Fat Meal on Blood Flow Regulation during Arm Exercise

A diet high in saturated fats results in endothelial dysfunction and can lead to atherosclerosis, a precursor to cardiovascular disease. Exercise training is a potent stimulus though to mitigate the negative effects of a high saturated fat diet; however, it is unclear how high-saturated fat meal (HSFM) consumption impacts blood flow regulation during a single exercise session. PURPOSE: This study sought to examine the impact of a single HSFM on peripheral vascular function during an acute upper limb exercise bout. METHODS: Ten young healthy individuals completed two sessions of progressive handgrip exercise. Subjects either consumed a HSFM (0.84 g of fat/kg of body weight) 4 hours prior or remained fasted before the exercise bout. Progressive rhythmic handgrip exercise (6kg, 12kg, 18kg) was performed for 3 minutes per stage at rate of 1 Hz. The brachial artery (BA) diameter and blood velocity was obtained using Doppler Ultrasound (GE Logiq e) and BA blood flow was calculated with these values. RESULTS: BA blood flow and flow mediated dilation (normalized for shear rate) during the handgrip exercise significant increased from baseline in all workloads, but no differences were revealed in response to the HSFM consumption. CONCLUSION: Progressive handgrip exercise augmented BA blood flow and flow mediated dilation in both testing days; however, there was no significant differences following the HSFM consumption. This suggests that upper limb blood flow regulation during exercise is unaltered by a high fat meal in young healthy individuals.https://scholarscompass.vcu.edu/gradposters/1060/thumbnail.jp