A Study on the Capacity of Normal and talpid3 Mutant Myogenic Cells to Migrate in Fowl Embryonic Wing Buds

1. The ability of myogenic cells to migrate within chick wing bud was investigated using quail cell markers. Fragments of quail wing buds containing myogenic cells of somitic origin were excised from stage 20-26 H. H. embryos and olthotropically implanted into chick wing buds in ovo. The chimaeric limbs were fixed for analysis at daily intervals. It was not until after the second day of implantation that quail cells started migrating out of the graft sites. Quail chondrocytes were found at the graft sites but they were non invasive. After the third day of implantation, quail cells were detected in most of the muscle regions in the zeugopod, but it was not until after the fourth day that quail cells were discernible in the autopod. Myogenic cell migration was exclusively in a proximodistal direction, with very little or no concurrent movement in the opposite direction

Excess caffeine exposure impairs eye development during chick embryogenesis

Caffeine has been an integral component of our diet and medicines for centuries. It is now known that over consumption of caffeine has detrimental effects on our health, and also disrupts normal foetal development in pregnant mothers. In this study, we investigated the potential teratogenic effect of caffeine over-exposure on eye development in the early chick embryo. Firstly, we demonstrated that caffeine exposure caused chick embryos to develop asymmetrical microphthalmia and induced the orbital bone to develop abnormally. Secondly, caffeine exposure perturbed Pax6 expression in the retina of the developing eye. In addition, it perturbed the migration of HNK-1(+) cranial neural crest cells. Pax6 is an important gene that regulates eye development, so altering the expression of this gene might be the cause for the abnormal eye development. Thirdly, we found that reactive oxygen species (ROS) production was significantly increased in eye tissues following caffeine treatment, and that the addition of anti-oxidant vitamin C could rescue the eyes from developing abnormally in the presence of caffeine. This suggests that excess ROS induced by caffeine is one of the mechanisms involved in the teratogenic alterations observed in the eye during embryogenesis. In sum, our experiments in the chick embryo demonstrated that caffeine is a potential teratogen. It causes asymmetrical microphthalmia to develop by increasing ROS production and perturbs Pax6 expression

SBTRec- A Transformer Framework for Personalized Tour Recommendation Problem with Sentiment Analysis

When traveling to an unfamiliar city for holidays, tourists often rely on guidebooks, travel websites, or recommendation systems to plan their daily itineraries and explore popular points of interest (POIs). However, these approaches may lack optimization in terms of time feasibility, localities, and user preferences. In this paper, we propose the SBTRec algorithm: a BERT-based Trajectory Recommendation with sentiment analysis, for recommending personalized sequences of POIs as itineraries. The key contributions of this work include analyzing users' check-ins and uploaded photos to understand the relationship between POI visits and distance. We introduce SBTRec, which encompasses sentiment analysis to improve recommendation accuracy by understanding users' preferences and satisfaction levels from reviews and comments about different POIs. Our proposed algorithms are evaluated against other sequence prediction methods using datasets from 8 cities. The results demonstrate that SBTRec achieves an average F1 score of 61.45%, outperforming baseline algorithms. The paper further discusses the flexibility of the SBTRec algorithm, its ability to adapt to different scenarios and cities without modification, and its potential for extension by incorporating additional information for more reliable predictions. Overall, SBTRec provides personalized and relevant POI recommendations, enhancing tourists' overall trip experiences. Future work includes fine-tuning personalized embeddings for users, with evaluation of users' comments on POIs,~to further enhance prediction accuracy

BTRec: BERT-Based Trajectory Recommendation for Personalized Tours

An essential task for tourists having a pleasant holiday is to have a well-planned itinerary with relevant recommendations, especially when visiting unfamiliar cities. Many tour recommendation tools only take into account a limited number of factors, such as popular Points of Interest (POIs) and routing constraints. Consequently, the solutions they provide may not always align with the individual users of the system. We propose an iterative algorithm in this paper, namely: BTREC (BERT-based Trajectory Recommendation), that extends from the POIBERT embedding algorithm to recommend personalized itineraries on POIs using the BERT framework. Our BTREC algorithm incorporates users' demographic information alongside past POI visits into a modified BERT language model to recommend a personalized POI itinerary prediction given a pair of source and destination POIs. Our recommendation system can create a travel itinerary that maximizes POIs visited, while also taking into account user preferences for categories of POIs and time availability. Our recommendation algorithm is largely inspired by the problem of sentence completion in natural language processing (NLP). Using a dataset of eight cities of different sizes, our experimental results demonstrate that our proposed algorithm is stable and outperforms many other sequence prediction algorithms, measured by recall, precision, and F1-scores.Comment: RecSys 2023, Workshop on Recommenders in Touris

A Gentleman with Anemia and Cholestasis

Primary sclerosing cholangitis is a rare cause of cholestasis caused by progressive inflammation and fibrosis of both intrahepatic and extrahepatic bile ducts leading to multifocal ductal strictures. Herein, we report a case of primary sclerosing cholangitis and inflammatory bowel disease. The concomitant diagnosis of these two diseases is not typical. The management includes the treatment of inflammatory bowel disease and potential complications of primary sclerosing cholangitis, including dominant strictures of bile duct, portal hypertension, gallbladder diseases, cholangiocarcinoma, and colonoscopic surveillance

Hearing Loss in Patients with Nasopharyngeal Carcinoma after Chemotherapy and Radiation

In light of the possible adverse effects of radiation on hearing, we conducted a study to evaluate the long-term sensorineural hearing status following radiotherapy (RT) in patients suffering from nasopharyngeal carcinoma. Audiologic examinations were performed at regular intervals before and after RT. We also analyzed the effects of age, chemotherapy, pre-RT hearing status, and post-RT otitis media with effusion (OME) on post-RT hearing change. A total of 150 patients (261 ears) were enrolled in this study and followed up for a mean of 43.8 months. After RT, 8.9-28.8% of ears had at least a 10 dB loss in bone conduction threshold at speech frequency, which was defined as an average of hearing threshold at 0.5 kHz, 1 kHz, and 2 kHz, while the percentage was 18-34.2% at 4 kHz. Patient age was related to these changes at speech frequency, and the presence of post-RT OME was related to significant loss at both speech frequency and 4 kHz. Pre-RT hearing status and chemotherapy did not influence hearing change. To sum up, sensorineural hearing loss began as early as after completion of RT. Early changes may be transient, but the effect of radiation on hearing tended to be chronic and progressive

Measurement of Blood Pressure Using an Arterial Pulsimeter Equipped with a Hall Device

To measure precise blood pressure (BP) and pulse rate without using a cuff, we have developed an arterial pulsimeter consisting of a small, portable apparatus incorporating a Hall device. Regression analysis of the pulse wave measured during testing of the arterial pulsimeter was conducted using two equations of the BP algorithm. The estimated values of BP obtained by the cuffless arterial pulsimeter over 5 s were compared with values obtained using electronic or liquid mercury BP meters. The standard deviation between the estimated values and the measured values for systolic and diastolic BP were 8.3 and 4.9, respectively, which are close to the range of values of the BP International Standard. Detailed analysis of the pulse wave measured by the cuffless radial artery pulsimeter by detecting changes in the magnetic field can be used to develop a new diagnostic algorithm for BP, which can be applied to new medical apparatus such as the radial artery pulsimeter

Examining consumers’ adoption of wearable healthcare technology: The role of health attributes

With the advancement of information technology, wearable healthcare technology has emerged as one of the promising technologies to improve the wellbeing of individuals. However, the adoption of wearable healthcare technology has lagged when compared to other well-established durable technology products, such as smartphones and tablets, because of the inadequate knowledge of the antecedents of adoption intention. The aim of this paper is to address an identified gap in the literature by empirically testing a theoretical model for examining the impact of consumers’ health beliefs, health information accuracy, and the privacy protection of wearable healthcare technology on perceived usefulness. Importantly, this study also examines the influences of perceived usefulness, consumer innovativeness, and reference group influence on the adoption intention of wearable healthcare technology. The model seeks to enhance understanding of the influential factors in adopting wearable healthcare technology. Finally, suggestions for future research for the empirical investigation of the model are provided

A Human Embryo of Carnegie Stage 12

A human embryo obtained from a salpinx removed for the treatment of tubal gestation was serially sectioned and observed. On gross examination, the embryo showed three prominent pharyngeal arches, but not the cervical sinus. The upper arm bud had just begun to appear with a slight elevation in the skin ectoderm. Both the anterior and posterior neuropores had already been closed. The heart was at the cardiac loop stage. The respiratory diverticulum, the dorsal pancreas and the beginning of the omental bursa had appeared. In the pharyngeal region, the adenohypophyseal pocket and the thyroid anlage were observed. The optic evagination showed no regional differentiation yet. From the above findings, we concluded that this embryo belonged to Carnegie stage 12