5,769 research outputs found
Investigation of the SH3BP2 Gene Mutation in Cherubism
Cherubism is a rare developmental lesion of the jaw that is generally inherited as an autosomal dominant trait. Recent studies have revealed point mutations in the SH3BP2 gene in cherubism patients. In this study, we examined a 6-year-old Korean boy and his family. We found a Pro418Arg mutation in the SH3BP2 gene of the patient and his mother. A father and his 30-month-old younger brother had no mutations. Immunohistochemically, the multinucleated giant cells proved positive for CD68 and tartrate-resistant acid phosphatase (TRAP). Numerous spindle-shaped stromal cells expressed a ligand for receptor activator of nuclear factor kB (RANKL), but not in multinucleated giant cells. These results provide evidence that RANKL plays a critical role in the differentiation of osteoclast precursor cells to multinucleated giant cells in cherubism. Additionally, genetic analysis may be a useful method for differentiation of cherubism.</p
Geographical distribution of typhoid risk factors in low and middle income countries
Overdispersion. Appendix 2. Full specification of regression outputs. Appendix 3. TRF index (type 5) by sub-national boundary. Appendix 4. Final TRF index values by sub-national boundary. Appendix 5. TRF index in Bangladesh. (ZIP 1995 kb
Optical spectroscopic investigation on the coupling of electronic and magnetic structure in multiferroic hexagonal RMnO3 (R = Gd, Tb, Dy, and Ho) thin films
We investigated the effects of temperature and magnetic field on the
electronic structure of hexagonal RMnO3 (R = Gd, Tb, Dy, and Ho) thin films
using optical spectroscopy. As the magnetic ordering of the system was
disturbed, a systematic change in the electronic structure was commonly
identified in this series. The optical absorption peak near 1.7 eV showed an
unexpectedly large shift of more than 150 meV from 300 K to 15 K, accompanied
by an anomaly of the shift at the Neel temperature. The magnetic field
dependent measurement clearly revealed a sizable shift of the corresponding
peak when a high magnetic field was applied. Our findings indicated strong
coupling between the magnetic ordering and the electronic structure in the
multiferroic hexagonal RMnO3 compounds.Comment: 16 pages including 4 figure
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