Essays on the Challenges to Labor Market Entry for Iraqi Refugees and Immigrants in the United States

This dissertation consists of three essays that explore the relationship between the U.S. Refugee Resettlement Program and the economic integration process of Iraqi refugees and immigrants in the United States. I utilize a mixed-method approach to explore the labor force activity and resettlement experiences of Iraqi refugees and immigrants. In the first paper, I explore the relationship between refugees and resettlement service providers using data obtained from interviews with service providers and multi-site participant observation at two resettlement agencies. The results indicate that ethnicity and gender have a critical influence in shaping the provision and utilization of resettlement services. In the second paper, I analyze the responses from face-to-face interviews I conducted with recently-arrived Iraqi refugees to identify the primary obstacles to socio-economic mobility they encountered during their initial resettlement in the United States. My findings suggest that the intersections of ethnicity, class, and gender interact to influence the labor force experiences of Iraqi refugees by informing job preferences and employability in the local labor market. The roles of ethnic-based social networks and institutional policies, as key components of the mode of reception, shape the refugees\u27 decision-making processes related to housing, education, and employment. In the third paper, I use data from a pooled sample of the 2005-2012 American Community Surveys to examine the determinants of socio-economic status of Iraqis by gender and ethnicity, and to explore their variation in labor market activity by U.S. metropolitan level Iraqi immigrant population composition. The implications from the results are that the type of employment and earnings of Iraqi immigrants and refugees are significantly affected according to the degree of Iraqi residential composition. The empirical results indicate that this effect of Iraqis on socio-economic status varies by ethnicity and gender. These essays contribute to the field of sociology by adding to our understanding of how the involvement of the government and intermediary agents in the refugee resettlement process shapes the refugee\u27s socio-economic trajectory, by contributing to the knowledge base of Iraqi socio-economic status in the U.S. within the field of migration studies, and by identifying the dynamic interactions between nationality, ethnicity, class, and gender in the labor market

Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection

This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827, 075470, 097377, 101873 & 200208) and MRC Centre for Medical Mycology (N006364/1). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.Peer reviewedPublisher PD

Framing issues of environmental security in Angola & Mozambique - the nexus of land, conflicts and sustainable livelihoods in post-conflict situations

ABSTRACT Violent and protracted conflicts, such as those that affected Mozambique and Angola (both countries with a Lusophone colonial heritage), have had severe consequences in terms of wartime dislocation and destruction, especially in rural areas. Land issues per se are not endogenously conflictive, but in post-conflict settings, the scramble for access to the assets necessary to (re-)establish livelihoods for large numbers of people, as well as the pursuit of land access by large-scale commercial interests who capitalise on a fluid land tenure situation to acquire resources, may occur. A nuanced and comparative study of Mozambique and Angola is undertaken that explores the relationship between violence, resources and the environment. It asks two questions: i) What accounts for the relationship between violence (evidenced in both brutal physical acts, threats and increasing vulnerabilities) and land as a resource? ii) Are there lessons to be learnt from these findings that are particular to countries emerging from protracted civil wars? The thesis explores the changing discourses around the concepts of human security and environmental security, and the pressing land issues confronting the African continent. It highlights the complexity of issues – political, social and economic – and the necessity for a theoretical shift away from the popular approaches towards alternative ways of understanding the connections between the environment, violence and resources. It examines the specific dynamics of a post-conflict environment, an area that has received little attention, despite its potential for playing a significant role in ensuring broad-based development and in peace-building. A modified livelihoods framework is also used to analyse land issues on the basis that land is an element of a wider livelihoods approach with a focus on poverty alleviation and wealth creation. Findings mirror those of other international researchers who have found that conflicts over land often have less to do with resource scarcity, but that “violence is more likely when resources are in great abundance or have great economic and strategic value” (Peluso and Watts, 2001: 5). Furthermore, findings support the calls for taking a more inclusive concept of violence and non-violence that recognises that the outward manifestation of disputes may not be violence in the form of civil war, but social disruptions (Liotta, 2005). The value of a post-structuralist political ecology for analysing these various connections is demonstrated in the research findings. It is one which does not search for ‘environmental triggers’ of violent conflicts, but looks at the reciprocal relationship between nature and humans. Both countries are confronting many of the land issues that are common to Africa and which suggest an important new phase in the politics of land. In Angola land tenure and shelter are now insecure for many in both rural and urban areas, while in both countries there is mounting competition and conflict over land and landed resources. There are increasing threats of exclusionary practices and land grabs, but also the more subtle, ‘non-traditional’ security threats of the destruction and damage to livelihoods, of deepening impoverishment, evident in "creeping vulnerabilities”. The findings of the research confirm that in dealing with both equity and efficiency issues, and environmental sustainability and political stability, land policies need to be well integrated into wider social, economic and environmental planning – at various levels, local to global – to strengthen sustainable security. vi Land conflicts are generally contained as local-level disputes, often camouflaged by government or suppressed. While conflict theory points to apparent triggers – differential impacts and political mobilisation – it must be acknowledged that these tensions are more often than not politically sustainable, as leaders justify overriding the interests of the poor in the interests of growth. Furthermore, peace is not the default mode of society: conflicts are at times an integral part of the transformation of land tenures systems and not necessarily destructive in themselves. Concerns need to focus, rather, on those cases where inequity and violence are politically sustainable, and what this means for human security. It is this issue that is recommended for further research. “In contrast to thinking about violent conflict, a human-centred conceptualisation of environmental security asserts the need for cooperation and inclusion to manage the environment for the equal benefit of all people and future generations” (Barnett, 2001: 128)

Safety and preliminary efficacy of vorinostat with R-EPOCH in high-risk HIV-associated non-Hodgkin\u27s lymphoma (AMC-075)

We performed a phase I trial of vorinostat (VOR) given on days 1 to 5 with R-EPOCH (rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride) in patients with aggressive HIV-associated non-Hodgkin lymphoma. VOR was tolerable at 300 mg and seemingly efficacious with chemotherapy with complete response rate of 83% and 1-year event-free survival of 83%. VOR did not significantly alter chemotherapy steady-state concentrations, CD4+ cell counts, or HIV viral loads. Vorinostat (VOR), a histone deacetylase inhibitor, enhances the anti-tumor effects of rituximab (R) and cytotoxic chemotherapy, induces viral lytic expression and cell killing in Epstein-Barr virus-positive (EBV+) or human herpesvirus-8-positive (HHV-8+) tumors, and reactivates latent human immunodeficiency virus (HIV) for possible eradication by combination antiretroviral therapy (cART). We performed a phase I trial of VOR given with R-based infusional EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride) (n = 12) and cART in aggressive HIV-associated B-cell non-Hodgkin lymphoma (NHL) in order to identify safe dosing and schedule. VOR (300 or 400 mg) was given orally on days 1 to 5 with each cycle of R-EPOCH for 10 high-risk patients with diffuse large B-cell lymphoma (1 EBV+), 1 EBV+/HHV-8+ primary effusion lymphoma, and 1 unclassifiable NHL. VOR was escalated from 300 to 400 mg using a standard 3 + 3 design based on dose-limiting toxicity observed in cycle 1 of R-EPOCH. The recommended phase II dose of VOR was 300 mg, with dose-limiting toxicity in 2 of 6 patients at 400 mg (grade 4 thrombocytopenia, grade 4 neutropenia), and 1 of 6 treated at 300 mg (grade 4 sepsis from tooth abscess). Neither VOR, nor cART regimen, significantly altered chemotherapy steady-state concentrations. VOR chemotherapy did not negatively impact CD4+ cell counts or HIV viral loads, which decreased or remained undetectable in most patients during treatment. The response rate in high-risk patients with NHL treated with VOR(R)-EPOCH was 100% (complete 83% and partial 17%) with a 1-year event-free survival of 83% (95% confidence interval, 51.6%-97.9%). VOR combined with R-EPOCH was tolerable and seemingly efficacious in patients with aggressive HIV-NHL

A comfort comparison of travoprost BAK-free 0.004% versus latanoprost 0.005% in patients with primary open-angle glaucoma or ocular hypertension

David A Godfrey1, Lee S Peplinski2, Jeanette A Stewart3, William C Stewart31Glaucoma Associates of Texas, Dallas, TX, USA; 2Kentuckiana Institute for Eye Research, Louisville, KY, USA; 3PRN Pharmaceutical Research Network, LLC, Dallas, TX, USAPurpose: To determine the short-term comfort after a single dose of travoprost BAK-free compared to latanoprost in primary open-angle glaucoma or ocular hypertensive patients.Design: Prospective, double-masked, randomized comparison of two separate active agents dosed once in opposite eyes.Methods: At Visit 1, qualified patients began a glaucoma medicine-free period for three days. At Visit 2, patients were randomly assigned to travoprost BAK-free or latanoprost in opposite eyes. Following dosing in each eye, patients completed a visual analog scale (VAS score, 0–100 mm) at specified time intervals and a comfort survey.Results: In 54 completed subjects, no difference existed five seconds after dosing, in comfort on the VAS between latanoprost (7.1 ± 16.2 mm) and travoprost BAK-free (7.8 ± 16.1 mm, P = 0.53). Also no differences existed between treatments following dosing for discomfort at individual timepoints past five seconds, peak discomfort or the time required to return to baseline comfort (P > 0.05). In addition, the comfort survey demonstrated no difference between products for burning, stinging, foreign body sensation, overall comfort and general acceptance between the products, both for absolute levels and changes from baseline (P > 0.05).Conclusion: Following a single instillation, both latanoprost and travoprost BAK-free exhibit similar comfort scores.Keywords: comfort, travoprost BAK-free, latanoprost, glaucoma, ocular hypertensio

Ground-level climate at a peatland wind farm in Scotland is affected by wind turbine operation

The global drive to produce low-carbon energy has resulted in an unprecedented deployment of onshore wind turbines, representing a significant land use change for wind energy generation with uncertain consequences for local climatic conditions and the regulation of ecosystem processes. Here, we present high-resolution data from a wind farm collected during operational and idle periods that shows the wind farm affected several measures of ground-level climate. Specifically, we discovered that operational wind turbines raised air temperature by 0.18 °C and absolute humidity (AH) by 0.03 g m−3 during the night, and increased the variability in air, surface and soil temperature throughout the diurnal cycle. Further, the microclimatic influence of turbines on air temperature and AH decreased logarithmically with distance from the nearest turbine. These effects on ground-level microclimate, including soil temperature, have uncertain implications for biogeochemical processes and ecosystem carbon cycling, including soil carbon stocks. Consequently, understanding needs to be improved to determine the overall carbon balance of wind energy

Killer instincts: natural killer cells as multifactorial cancer immunotherapy

Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of individual cells to putative targets. Against cancers, which mutate and evolve under therapeutic and immunologic pressure, the diversity for recognition provided by NK cells may be key to comprehensive cancer control. NK cells are already being trialled as adoptive cell therapy and targets for immunotherapeutic agents. However, strategies to leverage their naturally occurring diversity and agility have not yet been developed. In this review, we discuss the receptors and signaling pathways through which signals for activation or inhibition are generated in NK cells, focusing on their roles in cancer and potential as targets for immunotherapies. Finally, we consider the impacts of receptor co-expression and the potential to engage multiple pathways of NK cell reactivity to maximize the scope and strength of antitumor activities

Cell biology of Candida albicans-host interactions

Acknowledgements The authors are supported by the Wellcome Trust via a Senior Investigator Award to NG, an ISST award and a Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology. The authors are also part of the MRC Centre for Medical Mycology at Aberdeen.Peer reviewedPublisher PD