Analysis of Multi-Layered Materials under High Velocity Impact Using CTH

Multi-layer armor containing ceramic and metallic layers has become more common in the past two decades. Typically, ceramics have high compressive strength which combined with their low density make them highly desirable for armor applications. This research effort numerically simulates high velocity impact of cylindrical projectiles on multi-layer metallic and ceramic targets of finite thickness. The impact of the projectile occurs normal to the surface of the target. The projectiles used are made of either S7 tool steel or tungsten. The targets consist of either rolled homogeneous armor, 4340 steel and boron carbide ceramic or rolled homogeneous armor and boron carbide ceramic. The Eulerian hydrocode CTH, ideal for studying cases of gross global and local deformation, is used to perform an axisymmetric analysis of the projectile and the target. The Johnson-Holmquist constitutive model (JH-2) for brittle materials is used for the ceramic layers, and the Johnson-Cook constitutive model is used for the metallic layers. Various arrangements of ceramic and metallic layers were simulated over a range of velocities to quantitatively determine ballistic limits. Comparison of the ballistic limits for each configuration will determine which ceramic-metal lay-up arrangement is optimal for resisting penetration of the given projectile. A variety of options in CTH are taken into account in this research. This research shows that replacing multiple metallic target layers with B4C ceramic decreases the resistance of the target to the penetration of the projectile for a target of given thickness

Heterogeneous Investors and their Changing Demand and Supply Schedules for Individual Common Stocks

Using 550 million limit orders submitted in the Korea Stock Exchange, we estimate demand and supply elasticities of heterogeneous investor types and their changes around the Asian financial crisis. We find that domestic individuals have substantially more inelastic demand and supply curves than domestic institutions and foreign investors. The crisis permanently reduced price elasticities of domestic individuals by 50% but had no effect on those of foreign investors. Institutional changes restricting margin purchases, implemented after the crisis, seem particularly important in explaining the dramatic drop. Information heterogeneity, availability of close substitutes and arbitrage risk also explain time-series variations in elasticities.

RnaseIII and T4 Polynucleotide Kinase Sequence Biases and Solutions During RNA-Seq Library Construction

Background: RNA-seq is a next generation sequencing method with a wide range of applications including single nucleotide polymorphism (SNP) detection, splice junction identification, and gene expression level measurement. However, the RNA-seq sequence data can be biased during library constructions resulting in incorrect data for SNP, splice junction, and gene expression studies. Here, we developed new library preparation methods to limit such biases. Results: A whole transcriptome library prepared for the SOLiD system displayed numerous read duplications (pile-ups) and gaps in known exons. The pile-ups and gaps of the whole transcriptome library caused a loss of SNP and splice junction information and reduced the quality of gene expression results. Further, we found clear sequence biases for both 5' and 3' end reads in the whole transcriptome library. To remove this bias, RNaseIII fragmentation was replaced with heat fragmentation. For adaptor ligation, T4 Polynucleotide Kinase (T4PNK) was used following heat fragmentation. However, its kinase and phosphatase activities introduced additional sequence biases. To minimize them, we used OptiKinase before T4PNK. Our study further revealed the specific target sequences of RNaseIII and T4PNK. Conclusions: Our results suggest that the heat fragmentation removed the RNaseIII sequence bias and significantly reduced the pile-ups and gaps. OptiKinase minimized the T4PNK sequence biases and removed most of the remaining pile-ups and gaps, thus maximizing the quality of RNA-seq data.National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA12404, AA019382, AA020926, AA016648National Institutes of Health (NIH) R01 GM088344Waggoner Center for Alcohol and Addiction Researc

Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease

A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as "guttate leukoderma," this skin finding is a rarely-reported presentation of Darier disease. It has been theorized that the mutation in ATP2A2 causes defective E-cadherin, which in turn disrupts the adhesion of melanocytes to keratinocytes, thus leading to impaired dendrite formation, hindered melanin transfer, and ultimately to melanocyte apoptosis. Herein, we contribute a case of a 56-year old woman who presented with the rarely-described guttate leukoderma of Darier disease and acrokeratosis verruciformis of Hopf