Documenting the Impact of a Food Pantry Program in Promoting Stability and Independence Among New Haven Residents

An estimated 22% of New Haven residents live with food insecurity. This means more than 1 in 5 residents of New Haven do not have enough food or enough money to buy food. Notably, issues of food insecurity disproportionately affect people of color and those of lower socioeconomic status, therefore exacerbating disparities in health issues related to food insecurity.2 Christian Community Action (CCA) is a local social service organization that provides housing, financial assistance, food, and other support services for low-income New Haven residents. Their food pantry program, which operates on an appointment-only basis, has regularly provided food to over 80 individuals and families in the New Haven area. CCA is interested in identifying areas for improvement to strengthen their service provision and are also collecting data to bolster their advocacy efforts. The objectives of this project are as follows: 1. Assess satisfaction amongst users of a food pantry program in New Haven. 2. Develop a sustainable method for obtaining and incorporating feedback for quality improvement processes. 3. Strengthen understanding of how usage of CCA’s food pantry promotes stability and independence among food pantry users.https://elischolar.library.yale.edu/ysph_pbchrr/1030/thumbnail.jp

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In this work, hydrate inhibition performance of water-soluble polymers including pyrrolidone, caprolactam, acrylamide types were evaluated using torque measurement and high pressure differential scanning calorimeter (HP ??-DSC). The obtained experimental results suggest that the studied polymers represent the kinetic hydrate inhibition (KHI) performance. 0.5 wt% polyvinylcaprolactam (PVCap) solution shows the hydrate onset time of 34.4 min and subcooling temperature of 15.9 K, which is better KHI performance than that of pure water - hydrate onset time of 12.3 min and subcooling temperature of 6.0 K. 0.5 wt% polyvinylpyrrolidone (PVP) solution shows the hydrate onset time of 27.6 min and the subcooling temperature of 13.2 K while polyacrylamide-co-acrylic acid partial sodium salt (PAM-co-AA) solution shows less KHI performance than PVP solution at both 0.5 and 5.0 wt%. However, PAM-co-AA solution shows slow growth rate and low hydrate amount than PVCap. In addition to hydrate onset and growth condition, torque change with time was investigated as one of KHI evaluation methods. 0.5 wt% PVCap solution shows the lowest average torque of 6.4 N cm and 0.5 wt% PAM-co-AA solution shows the average torque of 7.2 N cm. For 0.5 wt% PVP solution, it increases 11.5 N cm and 5.0 wt% PAM-co-AA solution shows the maximum average torque of 13.4 N cm, which is similar to the average torque of pure water, 15.2 N cm. Judging from the experimental results obtained by both an autoclave and a HP ??-DSC, the PVCap solution shows the best performance among the KHIs in terms of delaying hydrate nucleation. From these results, it can be concluded that the torque change with time is useful to identify the flow ability of tested solution, and the further research on the inhibition of hydrate formation can be approached in various aspects using a HP ??-DSC. ??? ??????????????? ?????? ????????? ?????? ???????????? ???????????? ???????????? pyrrolidone, caprolactam, acrylamide ?????? ????????? ??????????????? ?????????????????? ?????? ????????? ???????????????. ?????? ??????, ??? ????????? ???????????? ?????? ??????????????? ?????????????????? ??????????????? ????????? ???????????? ????????? ??????????????????, ?????? 0.5 wt% polyvinylcaprolactam (PVCap)??? ?????? 34.4?????? ?????????????????? ?????? ??????, 15.9 K??? subcooling ????????? ????????? 12.3 ???, 6.0 K??? ?????? ??? ??????????????? ????????? ?????? ????????? ???????????????. 0.5 wt% polyvinylpyrrolidone (PVP)??? ?????? ?????? ????????? ?????? ????????? ????????????, polyacrylamide-co-acrylic acid partial sodium salt (PAM-co-AA)??? ?????? ?????? 0.5 wt%??? 5.0 wt%??? ???????????? ????????? ?????????????????? ?????? ????????? ?????????. ????????? ????????? ?????????????????? ????????? ??????????????? ?????? ???????????? PAM-co-AA??? PVCap??? ????????? ?????? ????????? ?????? ????????? ???????????????. ??? ?????? ?????? ?????? ?????? ?????? ??? ????????? ?????? ????????? ???????????? PVCap??? ?????? ?????? 6.4 N cm??? ?????? ?????? ????????? ????????????, 0.5 wt%??? PAM-co-AA ???????????? ?????? 7.2 N cm??? ????????? ??? ?????? ?????????. ?????? ???????????? ???????????? ????????? ????????? ????????? ????????? ?????? ?????? ?????? ????????? ????????? autoclave ????????? ????????? ???????????????. PVCap??? ????????? ?????? ????????????????????? ????????????????????? ??????????????? ?????? ????????? ??????????????? ????????? ?????? ???????????????.clos

Cumulative incidence of NTM in the depression group and non-depression group for matched cohorts.

Cumulative incidence of NTM in the depression group and non-depression group for matched cohorts.</p

aHR for NTM-PD in the depression group compared to the non-depression group.

aHR for NTM-PD in the depression group compared to the non-depression group.</p

Risks of NTM-PD measured by age and sex for matched cohorts.

Risks of NTM-PD measured by age and sex for matched cohorts.</p

Unprocessed Meat Consumption and Incident Cardiovascular Diseases in Korean Adults: The Korean Genome and Epidemiology Study (KoGES)

Meat consumption has been shown to be associated with cardiovascular disease (CVD) risk in Western societies; however, epidemiological data are limited on the Korean population. Therefore, we examined the associations between unprocessed meat consumption and CVD incidence in Korea. Data were derived from the Ansung-Ansan cohort (2001–2012), including 9370 adults (40–69 years) without CVD or cancer at baseline. Total unprocessed meat consumption was estimated as the sum of unprocessed red meat (beef, pork, and organ meat) and poultry consumption. In the fully adjusted Cox regression model, the relative risks of CVD across increasing quintiles of total unprocessed meat intake were 1.0 (reference), 0.72 (95% confidence interval (CI): 0.55, 0.95), 0.57 (95% CI: 0.42, 0.78), 0.69 (95% CI: 0.51, 0.95), and 0.69 (95% CI: 0.48, 0.97), but no significant linear trend was detected (p for trend = 0.14). Frequent poultry consumption was significantly associated with a decreased CVD risk; this association showed a dose-response relationship (p for trend = 0.04). This study showed that a moderate intake of total unprocessed meat was inversely associated with CVD risk. A significant inverse association between poultry consumption and incident CVD was observed in Korean adults, requiring further confirmation in other populations

The rice gene DEFECTIVE TAPETUM AND MEIOCYTES 1 (DTM1) is required for early tapetum development and meiosis

Tapetum development and meiosis play crucial roles in anther development. Here we identified a rice gene, DEFECTIVE TAPETUM AND MEIOCYTES 1 (DTM1), which controls the early stages of that development. This gene encodes for an endoplasmic reticulum (ER) membrane protein that is present only in cereals. Our T-DNA insertion mutations gave rise to abnormal tapetal formation. Cellular organelles, especially the ER, were underdeveloped, which led to hampered differentiation and degeneration of the tapetum. In addition, the development of pollen mother cells was arrested at the early stages of meiotic prophase I. RNA in-situ hybridization analyses showed that DTM1 transcripts were most abundant in tapetal cells at stages 6 and 7, and moderately in the pollen mother cells and meiocytes. Transcripts of UDT1, which functions in tapetum development during early meiosis, were reduced in dtm1 anthers, as were those of PAIR1, which is involved in chromosome pairing and synapsis during meiosis. However, expression of MSP1 and MEL1, which function in anther wall specification and germ cell division, respectively, was not altered in the dtm1 mutant. Moreover, transcripts of DTM1 were reduced in msp1 mutant anthers, but not in udt1 and pair1 mutants. These results, together with their mutant phenotypes, suggest that DTM1 plays important roles in the ER membrane during early tapetum development, functioning after MSP1 and before UDT1, and also in meiocyte development, after MEL1 and before PAIR1.X111211sciescopu

Flow chart of study population from the Korean National Health Insurance Service—National Sample Cohort.

Flow chart of study population from the Korean National Health Insurance Service—National Sample Cohort.</p

Baseline characteristics of the study population before and after exact matching.

Baseline characteristics of the study population before and after exact matching.</p

Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases.

Antiangiogenic agents have been widely investigated in combination with standard chemotherapy or targeted cancer agents for better management of advanced cancers. Therapeutic agents that concurrently inhibit epidermal growth factor receptor and other angiokinases could be useful alternatives to combination therapies for epidermal growth factor receptor-dependent cancers. Here, we report the synthesis of an indole derivative of pazopanib using a bioisosteric replacement strategy, which was designated MKP101. MKP101 inhibited not only the epidermal growth factor receptor with an IC50 value of 43 nM but also inhibited angiokinases as potently as pazopanib. In addition, MKP101 effectively inhibited vascular endothelial growth factor-induced endothelial proliferation, tube formation, migration of human umbilical vein endothelial cells and proliferation of HCC827, an epidermal growth factor receptor-addicted cancer cell line. A docking model of MKP101 and the kinase domain of the epidermal growth factor receptor was generated to predict its binding mode, and validated by synthesizing and evaluating MKP101 derivatives. Additionally, a study of structure-activity relationships of indolylamino or indolyloxy pyrimidine analogues derived from MKP101 demonstrated that selectivity for epidermal growth factor receptor and other angiokinases, especially vascular endothelial growth factor receptor 2 depends on the position of substituents on pyrimidine and the type of link between pyrimidine and the indole moiety. We believe that this study could provide a basis for developing angiokinase inhibitors having high affinity for the epidermal growth factor receptor, from the pyrimidine scaffold