Evaluation of Moisture Content Changes in Taiwan Red Cypress During Drying Using Ultrasonic and Tap-Tone Testing

Moisture content affects most of the important properties of wood, therefore it is important to control during drying and in use. The purpose of this study was to investigate moisture content changes in Taiwan red cypress during drying. Two types of nondestructive testing were used, ultrasonic and tap-tone. The results showed that ultrasonic and tap-tone velocities increased with decreasing moisture content with the major effect below the FSP. A second-order regression relationship was found between ultrasonic and tap-tone velocities with moisture content desorption during drying with a coefficient of determination of 0.77 and 0.88, respectively. Moreover, the effects of moisture content desorption on dynamic moduli, calculated from ultrasonic and tap-tone methods, were demonstrated. Finally, a new parameter (Vi/Vx), the ratio of initial velocity (before drying) to the velocity at any moisture content, was effectively applied to evaluate moisture content changes in wood during drying. The tap-tone method was found to be a reliable tool to measure moisture content changes during the drying of wood

Risk factors and clinical significance of bacteremia caused by Pseudomonas aeruginosa resistant only to carbapenems

Background/purposeCarbapenem-resistant Pseudomonas aeruginosa infections have been a challenge and issue in hospital settings. However, the clinical impact of P. aeruginosa blood isolates resistant only to carbapenems has never been discussed previously.MethodsTo assess the risk factors and clinical significance of bacteremia caused by carbapenem resistance only P. aeruginosa (CROPA), a 6-year retrospective case–control study was conducted. The CROPA strains were defined as isolates susceptible to ciprofloxacin, antipseudomonal penicillins and cephalosporins, and aminoglycosides but resistant to one antipseudomonal carbapenem (imipenem or meropenem) or both. The controls were selected among patients with bacteremia due to P. aeruginosa susceptible to all above classes of antipseudomonal antibiotics, which was defined as all-susceptible P. aeruginosa.ResultsTwenty-five patients had at least one blood culture positive for CROPA, and 50 controls had all-susceptible P. aeruginosa bacteremia. CROPA bacteremia had a high 30-day mortality rate (72.0%), as compared to 26.0% for the controls (p < 0.001). Through multivariate analysis, carbapenem exposure was the only risk factor for developing CROPA bacteremia (p = 0.002). A comparison between the surviving and deceased patients with CROPA bacteremia showed that nine (50%) of those who died, but none of the survivors, received carbapenems as the initial empirical therapy (p = 0.027).ConclusionCarbapenem exposure was associated with emergence of CROPA infections. Repeated carbapenem use in such patients might increase rates of inappropriate initial empirical treatment and mortality. Prudent carbapenem use is important to reduce the emergence of CROPA

Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression

The regulation of cell cycle entry is critical for cell proliferation and tumorigenesis. One of the key players regulating cell cycle progression is the F-box protein Skp2. Skp2 forms a SCF complex with Skp1, Cul-1, and Rbx1 to constitute E3 ligase through its F-box domain. Skp2 protein levels are regulated during the cell cycle, and recent studies reveal that Skp2 stability, subcellular localization, and activity are regulated by its phosphorylation. Overexpression of Skp2 is associated with a variety of human cancers, indicating that Skp2 may contribute to the development of human cancers. The notion is supported by various genetic mouse models that demonstrate an oncogenic activity of Skp2 and its requirement in cancer progression, suggesting that Skp2 may be a novel and attractive therapeutic target for cancers

Machine Learning-based Indoor Positioning Systems Using Multi-Channel Information

The received signal strength indicator (RSSI) is a metric of the power measured by a sensor in a receiver. Many indoor positioning technologies use RSSI to locate objects in indoor environments. Their positioning accuracy is significantly affected by reflection and absorption from walls, and by non-stationary objects such as doors and people. Therefore, it is necessary to increase transceivers in the environment to reduce positioning errors. This paper proposes an indoor positioning technology that uses the machine learning algorithm of channel state information (CSI) combined with fingerprinting. The experimental results showed that the proposed method outperformed traditional RSSI-based localization systems in terms of average positioning accuracy up to 6.13% and 54.79% for random forest (RF) and back propagation neural networks (BPNN), respectively

Machine Learning-based Indoor Positioning Systems Using Multi-Channel Information

The received signal strength indicator (RSSI) is a metric of the power measured by a sensor in a receiver. Many indoor positioning technologies use RSSI to locate objects in indoor environments. Their positioning accuracy is significantly affected by reflection and absorption from walls, and by non-stationary objects such as doors and people. Therefore, it is necessary to increase transceivers in the environment to reduce positioning errors. This paper proposes an indoor positioning technology that uses the machine learning algorithm of channel state information (CSI) combined with fingerprinting. The experimental results showed that the proposed method outperformed traditional RSSI-based localization systems in terms of average positioning accuracy up to 6.13% and 54.79% for random forest (RF) and back propagation neural networks (BPNN), respectively

Effect on Spasticity After Performance of Dynamic-Repeated-Passive Ankle Joint Motion Exercise in Chronic Stroke Patients

Spasticity associated with abnormal muscle tone is a common motor disorder following stroke, and the spastic ankle may affect ambulatory function. The purpose of this study was to investigate the short-term effect of dynamic-repeated-passive ankle movements with weight loading on ambulatory function and spastic hypertonia of chronic stroke patients. In this study, 12 chronic stroke patients with ankle spasticity and inefficient ambulatory ability were enrolled. Stretching of the plantar-flexors of the ankle in the standing position for 15 minutes was performed passively by a constant-speed and electrically powered device. The following evaluations were done before and immediately after the dynamic-repeated-passive ankle movements. Spastic hypertonia was assessed by the Modified Ashworth Scale (MAS; range, 0–4), Achilles tendon reflexes test (DTR; range, 0–4), and ankle clonus (range, 0–5). Improvement in ambulatory ability was determined by the timed up-and-go test (TUG), the 10-minute walking test, and cadence (steps/minute). In addition, subjective experience of the influence of ankle spasticity on ambulation was scored by visual analog scale (VAS). Subjective satisfaction with the therapeutic effect of spasticity reduction was evaluated by a five-point questionnaire (1 = very poor, 2 = poor, 3 = acceptable, 4 = good, 5 = very good). By comparison of the results before and after intervention, these 12 chronic stroke patients presented significant reduction in MAS and VAS for ankle spasticity, the time for TUG and 10-minute walking speed (p < 0.01). The cadence also increased significantly (p < 0.05). In addition, subjective satisfaction with the short-term therapeutic effect was mainly good (ranging from acceptable to very good). In conclusion, 15 minutes of dynamic-repeated-passive ankle joint motion exercise with weight loading in the standing position by this simple constant-speed machine is effective in reducing ankle spasticity and improving ambulatory ability

Risk factors for pulmonary tuberculosis in patients with chronic obstructive airway disease in Taiwan: a nationwide cohort study

BACKGROUND: An association between chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) has been described, mainly due to smoking and corticosteroid use. Whether inhaled corticosteroid (ICS) therapy is associated with an increased risk of TB remains unclear. METHODS: We selected COPD cases by using six diagnostic scenarios and control subjects from a nationwide health insurance database, and applied time-dependent Cox regression analysis to identify the risk factors for TB. RESULTS: Among 1,000,000 beneficiaries, 23,594 COPD cases and 47,188 non-COPD control subjects were selected. Cox regression analysis revealed that age, male gender, diabetes mellitus, end-stage renal disease, and cirrhosis, as well as COPD (hazard ratio = 2.468 [2.205–2.762]) were independent risk factors for TB. Among the COPD cases, those who developed TB received more oral corticosteroids and oral β-agonists. Time-dependent Cox regression analysis revealed that age, male gender, diabetes mellitus, low income, oral corticosteroid dose, and oral β-agonist dose, but not ICS dose, were independent risk factors for TB. The identified risk factors and their hazard ratios were similar among the COPD cases selected using different scenarios. CONCLUSION: Keeping a high suspicion and regularly monitoring for the development of pulmonary TB in COPD patients are necessary, especially for those receiving higher doses of oral corticosteroids and other COPD medications. Although ICS therapy has been shown to predispose COPD patients to pneumonia in large randomized clinical trials, it does not increase the risk of TB in real world practice