THE EFFECT OF APPLIED DIRECTION OF KINESIO TAPING IN ANKLE MUSCLE STRENGTH AND FLEXIBILITY

The purpose of this study was to examine the effect of applied direction of Kinesio taping (KT) in ankle range of motion and calf muscle strength. Twenty healthy subjects voluntarily participated in this study. The ankle plantar flexor muscle strength and ankle dorsiflexion ROM were assessed in knee flexion and knee extension before and after taping applied. Two applied directions, heel to posterior of knee cap (insertion to origin of calf muscles) and posterior of knee cap to heel (origin to insertion of calf muscles) were applied over both side of calf muscles, respectively. The results had not showed significantly difference in any of the results. The beneficial effects of applied direction of KT has not provided scientific evidence in this study. Future study may be able to seek other methods to identify the effect on strength or flexibility while KT applied

3,3′-Bis(4-fluoro­benz­yl)-1,1′-ethyl­enediimidazolium tribromidocuprate(I)

The title compound, (C22H22F2N4)[CuBr3], crystallizes with the cation situated on an inversion center and the anion on a twofold rotation axis along one Cu—Br bond. The two imidazole rings are in an anti configuration. The anion has a trigonal planar coordination geometry

Characterizing First Arrival Position Channels: Noise Distribution and Capacity Analysis

This paper addresses two fundamental problems in diffusive molecular communication: characterizing the first arrival position (FAP) density and bounding the information transmission capacity of FAP channels. Previous studies on FAP channel models, mostly captured by the density function of noise, have been limited to specific spatial dimensions, drift directions, and receiver geometries. In response, we propose a unified solution for identifying the FAP density in molecular communication systems with fully-absorbing receivers. Leveraging stochastic analysis tools, we derive a concise expression with universal applicability, covering any spatial dimension, drift direction, and receiver shape. We demonstrate that several existing FAP density formulas are special cases of this innovative expression. Concurrently, we establish explicit upper and lower bounds on the capacity of three-dimensional, vertically-drifted FAP channels, drawing inspiration from vector Gaussian interference channels. In the course of deriving these bounds, we unravel an explicit analytical expression for the characteristic function of vertically-drifted FAP noise distributions, providing a more compact characterization compared to the density function. Notably, this expression sheds light on a previously undiscovered weak stability property intrinsic to vertically-drifted FAP noise distributions.Comment: 30 pages; 3 figures, 1 table; this paper is submitted to IEEE Transactions on Communication

Derived pp-adic heights and the leading coefficient of the Bertolini--Darmon--Prasanna pp-adic LL-function

Let $E/\mathbf{Q}$ be an elliptic curve and let $p$ be an odd prime of good reduction for $E$. Let $K$ be an imaginary quadratic field satisfying the classical Heegner hypothesis and in which $p$ splits. In a previous work, Agboola--Castella formulated an analogue of the Birch--Swinnerton-Dyer conjecture for the $p$-adic $L$-function $L_{\mathfrak{p}}^{\rm BDP}$ of Bertolini--Darmon--Prasanna attached to $E/K$, assuming the prime $p$ to be ordinary for $E$. The goal of this paper is two-fold: (1) We formulate a $p$-adic BSD conjecture for $L_{\mathfrak{p}}^{\rm BDP}$ for all odd primes $p$ of good reduction. (2) For an algebraic analogue $F_{\overline{\mathfrak{p}}}^{\rm BDP}$ of $L_{\mathfrak{p}}^{\rm BDP}$, we show that the ``leading coefficient'' part of our conjecture holds, and that the ``order of vanishing'' part follows from the expected ``maximal non-degeneracy'' of an anticyclotomic $p$-adic height. In particular, when the Iwasawa--Greenberg Main Conjecture $(F_{\overline{\mathfrak{p}}}^{\rm BDP})=(L_{\mathfrak{p}}^{\rm BDP})$ is known, our results determine the leading coefficient of $L_{\mathfrak{p}}^{\rm BDP}$ at $T=0$ up to a $p$-adic unit. Moreover, by adapting the approach of Burungale--Castella--Kim in the $p$-ordinary case, we prove the main conjecture for supersingular primes $p$ under mild hypotheses.Comment: 34 page

The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates.

The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant neuronal deubiquitinase that is associated with Parkinson's disease. It contains a complex Gordian knot topology formed by the polypeptide chain alone. Using a combination of fluorescence-based kinetic measurements, we show that UCH-L1 has two distinct kinetic folding intermediates that are transiently populated on parallel pathways between the denatured and native states. NMR hydrogen-deuterium exchange (HDX) experiments indicate the presence of partially unfolded forms (PUFs) of UCH-L1 under native conditions. HDX measurements as a function of urea concentration were used to establish the structure of the PUFs and pulse-labelled HDX NMR was used to show that the PUFs and the folding intermediates are likely the same species. In both cases, a similar stable core encompassing most of the central β-sheet is highly structured and α-helix 3, which is partially formed, packs against it. In contrast to the stable β-sheet core, the peripheral α-helices display significant local fluctuations leading to rapid exchange. The results also suggest that the main difference between the two kinetic intermediates is structure and packing of α-helices 3 and 7 and the degree of structure in β-strand 5. Together, the fluorescence and NMR results establish that UCH-L1 neither folds through a continuum of pathways nor by a single discrete pathway. Its folding is complex, the β-sheet core forms early and is present in both intermediate states, and the rate-limiting step which is likely to involve the threading of the chain to form the 52-knot occurs late on the folding pathway.This work was supported by the National Science Council (99-2911-I-007-034 and 104-2113-M-001-016), National Tsing Hua University and Academia Sinica, Taiwan. S.-T.D.H. was supported by a Career Development Award (CDA- 00025/2010-C) from the International Human Frontier Science Program. The NMR spectra were obtained at the NMR facility of the Department of Chemistry, University of Cambridge and at the Core Facility for Protein Structural Analysis, supported by the National Core Facility Program for Biotechnology, Taiwan.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.jmb.2016.04.00

Cryptosporidiosis in a Leukemia Child with Severe Diarrhea

Protozoa of the genus Cryptoporidium are smallc occidian parasites that infect the mucosal epithelium of a variety of animals and humans, causing protracted diarrhea in immunodeficient or malnourished patients as well as selflimited illness in previously healthy individuals. Cryptosporidiosis in a resected appendix from a child with acute lymphoblastic leukemia is reported. He had had severe protracted watery diarrhea with abdominal pain for one month. The standard hematoxylin and eosin stain revealed many spherical, basophilic organisms on the apical surface of the mucosal epithelial cells. The various stages of the Cryptosporidium paroum were identified by electron microscopy. It is important to recognize this organism because it is a widespread pathogen of diarrheal illness and may cause life-threatening disease in immunocompromised patients especially in acquired immune deficiency syndrome patients

Manumycin from a new Streptomyces strain shows antagonistic effect against methicillin-resistant Staphylococcus aureus (MRSA)/vancomycin-resistant enterococci (VRE) strains from Korean Hospitals

An antimicrobial compound, highly effective against multidrug-resistant (MDR) bacteria, purified from a Streptomyces strain was identified as manumycin. The minimal inhibitory concentrations (MICs) of manumycin against 8 different strains of methicillin-resistant Staphylococcus aureus (MRSA) were ranged 2 to 32 μg/ml. Similarly, MICs of manumycin against 4 vancomycin-resistant enterococci (VRE) strains were ranged 8 to 32 μg/ml while it remained ineffective against 4 other VRE strains. Compared to vancomycin, manumycin provided slightly weaker activity against MRSA strains but stronger activity against 4 VRE strains. This is the first report of antagonistic effect of manumycin against MDR pathogens.Keywords: Manumycin, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE)African Journal of Biotechnology Vol. 12(17), pp. 2249-225