Case management of persons with acquired immunodeficiency syndrome in San Francisco.

The acquired immunodeficiency syndrome (AIDS) epidemic represents a growing challenge for the health care system and for case management models applied to persons with AIDS. The experience of San Francisco highlights some of the issues involved in developing a case management system appropriate to the needs of persons with AIDS, as well as providers, and payers. Dramatic growth in the size and complexity of the AIDS caseload and the involvement of public, health maintenance organization, and community providers has required the increasing formalization and centralization of case management roles. Persistent questions about the definition and goals of case management complicate development of these services

Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.

Members of the TGF-beta superfamily appear to modulate mesenchymal differentiation, including the processes of cartilage and bone formation. Nothing is yet known about the function of the TGF-beta-related factor vgr-1, also called bone morphogenetic protein-6 (BMP-6), and only limited studies have been conducted on the most closely related factors BMP-5, osteogenic protein-1 (OP-1) or BMP-7, and OP-2. Because vgr-1 mRNA has been localized in hypertrophic cartilage, this factor may play a vital role in endochondral bone formation. We developed antibodies to vgr-1, and documented that vgr-1 protein was expressed in hypertrophic cartilage of mice. To further characterize the role of this protein in bone differentiation, we generated CHO cells that overexpressed recombinant murine vgr-1 protein. Western blot analysis documented that recombinant vgr-1 protein was secreted into the media and was proteolytically processed to yield the mature vgr-1 molecule. To assess the biological activity of recombinant vgr-1 in vivo, we introduced the vgr-1-expressing CHO cells directly into the subcutaneous tissue of athymic nude mice. CHO-vgr-1 cells produced localized tumors, and the continuous secretion of vgr-1 resulted in tumors with a strikingly different gross and histological appearance as compared to the parental CHO cells. The tumors of control CHO cells were hemorrhagic, necrotic, and friable, whereas the CHO-vgr-1 tumors were dense, firm, and fibrotic. In contrast with control CHO tumors, the nests of CHO-vgr-1 tumor cells were surrounded by extensive connective tissue, which contained large regions of cartilage and bone. Further analysis indicated that secretion of vgr-1 from the transfected CHO tumor cells induced the surrounding host mesenchymal cells to develop along the endochondral bone pathway. These findings suggest that endochondral bone formation

Effect of antenna element properties and array orientation on performance of MIMO systems

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Anomalous centrality variation of minijet angular correlations in Au-Au collisions at 62 and 200 GeV from STAR

We have measured 2D autocorrelations for all charged hadrons in STAR with $p_{t}$ $>$ 0.15 GeV/c and $| \eta |$ $<$ 1 from Au+Au collisions at 62 and 200 GeV. The correlation structure is dominated by a peak centered at zero relative opening angles on $\eta$ and $\phi$ which we hypothesize is caused by minimum-bias jets (minijets). We observe a large excess of minijet correlations in more-central Au-Au collisions relative to binary-collision scaling (more correlated pairs than expected from surface emission or even volume emission). We also observe a sudden increase of the minijet peak amplitude and $\eta$ width relative to binary-collision scaling of scattered partons which occurs at an energy-dependent centrality point. There is a possible scaling of the transition point with transverse particle density.Comment: Quark Matter 2008 proceedings, submitted to Journal of Physics G. v2: added STAR Collaboration to author lis

K* production in Cu+Cu and Au+Au collisions at sqrt(s_{NN}) = 62.4 GeV and 200 GeV in STAR

We report the measurements of $p_T$ spectra of $K^*$ up to intermediate $p_T$ region in mid-rapidity through its hadronic decay channel using the STAR detector in Au+Au and Cu+Cu collisions at $\sqrt{s_{\mathrm{NN}}}$= 62.4 GeV and 200 GeV. Particle ratios such as $K^{*}/K$ and $K^{*}/\phi$ is used to understand the rescattering and regeneration effect on $K^{*}$ production in the hadronic medium. The $K^*$ $v_{2}$ measurement using a high statistics Au+Au 200 GeV dataset and nuclear modification factor measurement supports the quark coalescence model of particle production in the intermediate $p_T$ range.Comment: 5 page

STAR's measurement of Long-range forward-backward multiplicity correlations as the signature of "dense partonic matter" in the Heavy Ion collisions at sNN=\sqrt{s_{NN}}=200 GeV.}

Forward-backward multiplicity correlations have been measured with the STAR detector for Au+Au, Cu+Cu and {\it p+p} collisions at $\sqrt{s_{NN}}$ = 200 GeV. A strong, long-range correlation is observed for central heavy ion collisions that vanishes in semi-peripheral events and {\it pp} collisions. There is no apparent scaling of correlation strength with the number of participants involved in the collision. Both the Dual Parton Model and the Color Glass condensate indicate that the long range correlations are due to multiple parton interactions. This suggests that the dense partonic matter might have been created in mid-central and central Au+Au collisions at $\sqrt{s_{NN}}$ = 200 GeV.Comment: 4 pages, 3 figures,presented at the 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions, "Quark Matter 2008", Jaipur, India, February 4-10, 200