42 research outputs found
Tap: A Novel Cellular Protein That Interacts with Tip of Herpesvirus Saimiri and Induces Lymphocyte Aggregation
AbstractTip of herpesvirus saimiri associates with Lck and down-regulates Lck-mediated activation. We identified a novel cellular Tip-associated protein (Tap) by a yeast two-hybrid screen. Tap associated with Tip following transient expression in COS-1 cells and stable expression in human Jurkat-T cells. Expression of Tip and Tap in Jurkat-T cells induced dramatic cell aggregation. Aggregation was likely caused by the up-regulated surface expression of adhesion molecules including integrin α, L-selectin, ICAM-3, and H-CAM. Furthermore, NF-ÎșB transcriptional factor of aggregated cells had approximately 40-fold higher activity than that of parental cells. Thus, Tap is likely to be an important cellular mediator of Tip function in T cell transformation by herpesvirus saimiri
Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1
An Antiviral Small-Interfering RNA Simultaneously Effective against the Most Prevalent Enteroviruses Causing Acute Hemorrhagic Conjunctivitis
Dual-Design Expandable Colorectal Stent for a Malignant Colorectal Obstruction: Preliminary Prospective Study Using New 20-mm Diameter Stents
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