The search for the 'next' euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning

Purpose: A detailed review on the chemistry and pharmacology of non-fentanil novel synthetic opioid receptor agonists, particularly N-substituted benzamides and acetamides (known colloquially as U-drugs) and 4-aminocyclohexanols, developed at the Upjohn Company in the 1970s and 1980s is presentedMethod: Peer-reviewed literature, patents, professional literature, data from international early warning systems and drug user fora discussion threads have been used to track their emergence as substances of abuse.Results: In terms of impact on drug markets, prevalence and harm, the most significant compound of this class to date has been U-47700 (trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide), reported by users to give short-lasting euphoric effects and a desire to re-dose. Since U-47700 was internationally controlled in 2017, a range of related compounds with similar chemical structures, adapted from the original patented compounds, have appeared on the illicit drugs market. Interest in a structurally unrelated opioid developed by the Upjohn Company and now known as BDPC/bromadol appears to be increasing and should be closely monitored.Conclusions: International early warning systems are an essential part of tracking emerging psychoactive substances and allow responsive action to be taken to facilitate the gathering of relevant data for detailed risk assessments. Pre-emptive research on the most likely compounds to emerge next, so providing drug metabolism and pharmacokinetic data to ensure that new substances are detected early in toxicological samples is recommended. As these compounds are chiral compounds and stereochemistry has a large effect on their potency, it is recommended that detection methods consider the determination of configuration

A critical assessment of UH-60 main rotor blade airfoil data

Many current comprehensive rotorcraft analyses employ lifting-line methods that require main rotor blade airfoil data, typically obtained from wind tunnel tests. In order to effectively evaluate these lifting-line methods, it is of the utmost importance to ensure that the airfoil section data are free of inaccuracies. A critical assessment of the SC1095 and SC1094R8 airfoil data used on the UH-60 main rotor blade was performed for that reason. Nine sources of wind tunnel data were examined, all of which contain SC1095 data and four of which also contain SC1094R8 data. Findings indicate that the most accurate data were generated in 1982 at the 11-Foot Wind Tunnel Facility at NASA Ames Research Center and in 1985 at the 6-inch by 22-inch transonic wind tunnel facility at Ohio State University. It has not been determined if data from these two sources are sufficiently accurate for their use in comprehensive rotorcraft analytical models of the UH-60. It is recommended that new airfoil tables be created for both airfoils using the existing data. Additional wind tunnel experimentation is also recommended to provide high quality data for correlation with these new airfoil tables