Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women

While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5×10−8), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1×10−29) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes

Economic segregation and urban growth

Many studies have investigated the socioeconomic consequences of residential economic segregation in U.S. urban areas. These studies mainly focus on the impact of economic segregation on the poor or minorities and almost universally find that economic segregation hurts these groups in many ways. However, few studies investigate how economic segregation relates to the economic growth of an urban area as a whole. While there are papers that study this issue theoretically, empirical evidence is lacking. The motivation of this paper is to fill this gap. Using U.S. census data, this study documents a significant negative relationship between the initial levels of economic segregation in 1980 and the subsequent economic growth, indexed by metropolitan population growth, in 1980-2000 in U.S. metropolitan statistical areas (MSAs). Holding other things constant, MSAs having higher initial levels of economic segregation experienced substantially slower subsequent population growth