Neighborhood Matters: The Impact of Resources on Online Participation of Warsaw Residents

This study examines the relationship between individual social capital and online participation in neighborhood of residents in a metropolitan city. Based on quantitative data collected through a modified version of the Resource Generator questionnaire among 9 063 residents of Warsaw, the impact of resources embedded in personal networks on online discussions on local issues is evaluated. It is found that resources in personal networks, perceived by  respondents as embedded but not mobilizable, negatively influence online talks focus on neighborhood. However, this impact turns into positive when they are able to mobilize resources available through social ties. Although some scholars suggest that social capital in the neighborhood declines, this study shows that neighbors remain considerable source of mobilizable resources affecting online discussions on local issues. Moreover, it is established that fact of being raised indigenously, relations with neighbors and trust in them may encourage urban residents to participate in neighborhood by discussing local issues online

Identyfikacja lokalna mieszkańców Zamojszczyzny

The purpose of the study was the diagnosis of social memory of the residents of the Zamojszczyzna region. The issue how respondents declare their ties to the sub region, which is manifested in a sense of identification with Zamojszczyzna region as a cultural area and human community, was also taken into account. The research release presents partial results of the survey, that fits thematically in the scope of research of identification with own living space.Celem badan była diagnoza pamięci społecznej mieszkańców Zamojszczyzny. Podjęto również kwestie deklarowanej przez respondentów więzi z subregionem, przejawiającej się w poczuciu identyfikacji z Zamojszczyzna jako obszarem kulturowym i zbiorowością ludzka. W komunikacie badawczym została zaprezentowana część wyników, która tematycznie wpisuje się w nurt badan nad identyfikacją ze swoja przestrzenią życiową

Report from the 6th International Meeting on Bone Marrow Adiposity (BMA2020)

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Zespół ROHHAD u 9-letniego chłopca — opis przypadku

  ROHHAD syndrome (Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation) is characterised by rapid-onset obesity in young children, hypoventilation, and hypothalamic and autonomic dysfunction. The exact aetiology of the disease remains unknown, and the number of reported cases seems to be underestimated. We present the case of a nine-year-old male patient suspected of ROHHAD due to weight gain since early childhood, decreased height velocity, hypoventilation, hypodipsia, excessive perspiration, and pyrexial episodes. The presented symptoms, and laboratory and imaging findings met the criteria of ROHHAD syndrome. ROHHAD should be considered in differential diagnosis for obesity in children. Early identification of the disease prevents potential complications specific for the syndrome, in particular a life-threatening cardio-pulmonary arrest. Patients with ROHHAD require regular follow-up by a multidisciplinary team. (Endokrynol Pol 2016; 67 (2): 226–231)    ROHHAD (Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic Dysregulation) to rzadki zespół charakteryzujący się pojawiającą się we wczesnym dzieciństwie szybko narastającą otyłością, hipowentylacją oraz zaburzeniami funkcji podwzgórza i układu autonomicznego. Przyczyny zespołu pozostają nieznane, a diagnostyka i postawienie ostatecznego rozpoznania nastręcza wielu trudności. Przypuszcza się, że liczba przypadków zespołu jest znacznie niedoszacowana. W pracy zaprezentowano pierwszy w Polsce przypadek 9-letniego pacjenta z otyłością, zwolnieniem szybkości wzrastania, zaburzeniami oddychania, hipodypsją, nadmierną potliwością i epizodami gorączek. Całość obrazu klinicznego, wyniki badań laboratoryjnych i obrazowych spełniają kryteria rozpoznania zespołu ROHHAD u prezentowanego pacjenta. Zespół ROHHAD powinien być brany pod uwagę w diagnostyce różnicowej otyłości u dzieci. Wczesne postawienie rozpoznania może pomóc uniknąć powikłań wpisanych w obraz zespołu i zabezpieczyć pacjenta przed najgroźniejszym z nich — czyli nagłym zatrzymaniem krążenia i oddechu. Pacjenci z zespołem ROHHAD wymagają wielospecjalistycznej opieki i systematycznych badań kontrolnych. (Endokrynol Pol 2016; 67 (2): 226–231)

PPARγ2 Regulates a Molecular Signature of Marrow Mesenchymal Stem Cells

Bone formation and hematopoiesis are anatomically juxtaposed and share common regulatory mechanisms. Bone marrow mesenchymal stromal/stem cells (MSC) contain a compartment that provides progeny with bone forming osteoblasts and fat laden adipocytes as well as fibroblasts, chondrocytes, and muscle cells. In addition, marrow MSC provide an environment for support of hematopoiesis, including the development of bone resorbing osteoclasts. The PPARγ2 nuclear receptor is an adipocyte-specific transcription factor that controls marrow MSC lineage allocation toward adipocytes and osteoblasts. Increased expression of PPARγ2 with aging correlates with changes in the MSC status in respect to both their intrinsic differentiation potential and production of signaling molecules that contribute to the formation of a specific marrow micro-environment. Here, we investigated the effect of PPARγ2 on MSC molecular signature in respect to the expression of gene markers associated exclusively with stem cell phenotype, as well as genes involved in the formation of a stem cell supporting marrow environment. We found that PPARγ2 is a powerful modulator of stem cell-related gene expression. In general, PPARγ2 affects the expression of genes specific for the maintenance of stem cell phenotype, including LIF, LIF receptor, Kit ligand, SDF-1, Rex-1/Zfp42, and Oct-4. Moreover, the antidiabetic PPARγ agonist TZD rosiglitazone specifically affects the expression of “stemness” genes, including ABCG2, Egfr, and CD44. Our data indicate that aging and anti-diabetic TZD therapy may affect mesenchymal stem cell phenotype through modulation of PPARγ2 activity. These observations may have important therapeutic consequences and indicate a need for more detailed studies of PPARγ2 role in stem cell biology

Structural Features of 1,3,4-Thiadiazole-Derived Ligands and Their Zn(II) and Cu(II) Complexes Which Demonstrate Synergistic Antibacterial Effects with Kanamycin

Classical synthetic protocols were applied for the isolation of three novel 1,3,4-thiadiazole derivatives which were then complexed with the biologically important Cu(II) and Zn(II) ions. All free ligands and their corresponding complexes were characterized using a number of spectroscopic techniques including Ultraviolet-visible (UV–vis), Fluorescence, Infrared (FT-IR), tandem liquid chromatography-mass (LC-MS), X-ray diffraction (XRD), and Nuclear Magnetic Resonance (NMR) spectroscopy (1H, 13C, HSQC, HMBC). The results obtained are consistent with the formation of dihydrate complexes, in which the chelation of the metal ion occurs via one of the thiadiazole nitrogen atoms and the deprotonated hydroxyl group of the neighboring resorcynyl moiety. The Zn(II) complexes utilize a 1:1 ligand–metal ratio, while in the Cu(II) complexes the ligand–metal ratio is 2:1. Although the antibacterial testing identified moderate activity of the compounds against the tested bacterial strains and additionally modest antioxidant activity, a strong synergistic antibacterial effect against Staphylococcus aureus, using concomitant treatment of thiadiazole derivatives with the commercial antibiotic kanamycin, was observed. The most active thiadiazole derivative demonstrated a minimal inhibitory concentration (MIC) of 500 μg/mL while it was 125 μg/mL in the presence of kanamycin. Moreover, in the presence of few thiadiazole derivatives the MIC value of kanamycin decreased from 0.39 μg/mL to 0.5 μg/mL. The antioxidant activity (IC50) of the most active thiadiazole derivative was determined as 0.13 mM which was nearly three-fold lower compared to that of TROLOX (0.5 mM)