1,518 research outputs found
‘Stick that knife in me’: Shane Meadows’ children
This article brings Shane Meadows’ Dead Man's Shoes (2004) into dialogue with the history of the depiction of the child on film. Exploring Meadows’ work for its complex investment in the figure of the child on screen, it traces the limits of the liberal ideology of the child in his cinema and the structures of feeling mobilised by its uses – at once aesthetic and sociological – of technologies of vision
Rarefaction effects on Galileo probe aerodynamics
Solutions of aerodynamic characteristics are presented for the Galileo Probe entering Jupiter's hydrogen-helium atmosphere at a nominal relative velocity of 47.4 km/s. Focus is on predicting the aerodynamic drag coefficient during the transitional flow regime using the direct simulation Monte Carlo (DSMC) method. Accuracy of the probe's drag coefficient directly impacts the inferred atmospheric properties that are being extracted from the deceleration measurements made by onboard accelerometers as part of the Atmospheric Structure Experiment. The range of rarefaction considered in the present study extends from the free molecular limit to continuum conditions. Comparisons made with previous calculations and experimental measurements show the present results for drag to merge well with Navier-Stokes and experimental results for the least rarefied conditions considered
Nonlinear Seebeck Effect in a Model Granular Superconductor
The change of the Josephson supercurrent density of a weakly-connected
granular superconductor in response to externally applied arbitrary thermal
gradient dT/dx (nonlinear Seebeck effect) is considered within a model of 3D
Josephson junction arrays. For dT/dx>(dT/dx)_c, where (dT/dx)_c is estimated to
be of the order of 10^4 K/m for YBCO ceramics with an average grain's size of
10 microns, the weak-links-dominated thermopower S (Seebeck coefficient) is
predicted to become strongly dT/dx-dependent.Comment: REVTEX, no figure
Analog of Magnetoelectric Effect in High-Tc Granular Superconductors
We propose the existence of an electric-field induced nonlinear magnetization
in a weakly coupled granular superconductor due to time-parity violation. As
the field increases the induced magnetization passes from para- to dia-magnetic
behavior. We discuss conditions under which this effect could be experimentally
measured in high-temperature superconductors.Comment: REVTEX (epsf style), 1 PS figure; to appear in Europhysics Letter
Limiting Carleman weights and anisotropic inverse problems
In this article we consider the anisotropic Calderon problem and related
inverse problems. The approach is based on limiting Carleman weights,
introduced in Kenig-Sjoestrand-Uhlmann (Ann. of Math. 2007) in the Euclidean
case. We characterize those Riemannian manifolds which admit limiting Carleman
weights, and give a complex geometrical optics construction for a class of such
manifolds. This is used to prove uniqueness results for anisotropic inverse
problems, via the attenuated geodesic X-ray transform. Earlier results in
dimension were restricted to real-analytic metrics.Comment: 58 page
Interaction of oestrogen and progesterone receptors with specific subfractions of laying-hen oviduct chromatin
HER2 testing in breast cancer: Opportunities and challenges
Human epidermal growth factor receptor 2 (HER2) is overexpressed in 15-25% of breast cancers, usually as a result of HER2 gene amplification. Positive HER2 status is considered to be an adverse prognostic factor. Recognition of the role of HER2 in breast cancer growth has led to the development of anti-HER2 directed therapy, with the humanized monoclonal antibody trastuzumab (Herceptin (R)) having been approved for the therapy of HER2-positive metastatic breast cancer. Clinical studies have further suggested that HER2 status can provide important information regarding success or failure of certain hormonal therapies or chemotherapies. As a result of these developments, there has been increasing demand to perform HER2 testing on current and archived breast cancer specimens. This article reviews the molecular background of HER2 function, activation and inhibition as well as current opinions concerning its role in chemosensitivity and interaction with estrogen receptor biology. The different tissue-based assays used to detect HER2 amplification and overexpression are discussed with respect to their advantages and disadvantages, when to test (at initial diagnosis or pre-treatment), where to test (locally or centralized) and the need for quality assurance to ensure accurate and valid testing results
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