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Seasonal changes in serum testosterone, 11-ketotestosterone, and 1713-estradiol levels in the brown bullhead, Ictalurus nebuIosus Lesueur
The seasonal changes in gonadosomatic index (GSI) and strum testosterone, I I-ketotestosterone, and 17&estmdiol levels
were measured in adult feral brown bullheads, Ictalurus nebulosus Lzsueur. The maximum GSI of both male and femalz brown
bullheads was consjderably lower than that of most other teleostean species investigated. lo males, the GSI began to increase
in April concomitant with an increase in water temperature from 3 to 6°C. The maximum GSI levels were evident throu_ghout
May and June (during the prespawning and spawning periods). Peaks of serum testosterone and serum 11-ketotesrosterone
leveb were evident in mid-April and late May to June, and in mid-April and mid-May, respxtively. In females here was a
rapid increase in GSI during May, when the ambient water temperamre reached 16°C. The peak GSI was evident in mid- to
late-May and had declined by early June. Peak serum testosterone and I 1-ketotestosterone levels were evident .in mid-April
and again in late May. wbereas peak 17P-estradiol levels were fou.nd in mid-May and mid-June. The peak serum teswsterone
levels in females were 4.5-fold higher than in the males, whereas che I I-ketotestosterone levels were similar in males and
females
Temperature-Induced Phase Shift of Daily Rhythm of Serum Prolactin in Gulf Killifish
Daily variations in circulating levels of the pituitary hormone prolactin have been reported in several vertebrates, including fishes. In some animals, the 24-h rhythm changes seasonally with respect to the time of day that maximum and minimum prolactin levels occur. It has been hypothesised that this seasonal change in phase of prolactin rhythm is an important component of the mechanism controlling seasonality in vertebrates. Because water temperature is generally considered the principal environmental regulator of seasonal changes in reproduction and metabolism in many fishes, including the gulf killifish Fundulus grandis, we determined the daily rhythm of serum prolactin concentrations in fish held at temperatures that are stimulatory (20 °C) or inhibitory (28 °C) for reproductive development. We found that an increase in water temperature from 20° to 28 °C phase shifts the daily variation of serum prolactin with respect to the daily photoperiod in F. grandis
Male reproductive health and environmental xenoestrogens
EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright.
Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or figures copyrighted by other commercial organizations and individuals that may not be used without obtaining prior approval from both the EHP editors and the holder of the copyright.
Use of any materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives") and a reference provided for the article from which the material was reproduced.Male reproductive health has deteriorated in many countries during the last few decades. In the 1990s, declining semen quality has been reported from Belgium, Denmark, France, and Great Britain. The incidence of testicular cancer has increased during the same time incidences of hypospadias and cryptorchidism also appear to be increasing. Similar reproductive problems occur in many wildlife species. There are marked geographic differences in the prevalence of male reproductive disorders. While the reasons for these differences are currently unknown, both clinical and laboratory research suggest that the adverse changes may be inter-related and have a common origin in fetal life or childhood. Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects. The growing number of reports demonstrating that common environmental contaminants and natural factors possess estrogenic activity presents the working hypothesis that the adverse trends in male reproductive health may be, at least in part, associated with exposure to estrogenic or other hormonally active (e.g., antiandrogenic) environmental chemicals during fetal and childhood development. An extensive research program is needed to understand the extent of the problem, its underlying etiology, and the development of a strategy for prevention and intervention.Supported by EU Contract BMH4-CT96-0314
Lawson criterion for ignition exceeded in an inertial fusion experiment
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion