5,271 research outputs found

    Chern classes and extraspecial groups

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    The mod-p cohomology ring of the extraspecial p-group of exponent p is studied for odd p. We investigate the subquotient ch(G) generated by Chern classes modulo the nilradical. The subring of ch(G) generated by Chern classes of one-dimensional representations was studied by Tezuka and Yagita. The subring generated by the Chern classes of the faithful irreducible representations is a polynomial algebra. We study the interplay between these two families of generators, and obtain some relations between them

    Realising fusion systems

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    We show that every fusion system on a p-group S is equal to the fusion system associated to a discrete group G with the property that every p-subgroup of G is conjugate to a subgroup of S

    Groups of type FPFP via graphical small cancellation

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    We construct an uncountable family of groups of type FPFP. In contrast to every previous construction of non-finitely presented groups of type FPFP we do not use Morse theory on cubical complexes; instead we use Gromov's graphical small cancellation theory.Comment: 3 figures. Second version: two paragraphs added emphasizing the difference between our construction and Morse theoretic one

    Realising fusion systems

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    We show that every fusion system (saturated or not) on a p-group S is equal to the fusion system associated to a discrete group G containing S as a subgroup and such that every finite subgroup of G is conjugate to a subgroup of S

    Human embryos from overweight and obese women display phenotypic and metabolic abnormalities

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    STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization they reach the morula stage faster and, as blastocysts, show reduced glucose consumption and elevated endogenous triglyceride levels. WHAT IS KNOWN ALREADY Female overweight and obesity is associated with infertility. Moreover, being overweight or obese around conception may have significant consequences for the unborn child, since there are widely acknowledged links between events occurring during early development and the incidence of a number of adult disorders. STUDY DESIGN, SIZE, DURATION We have performed a retrospective, observational analysis of oocyte size and the subsequent developmental kinetics of 218 oocytes from 29 consecutive women attending for ICSI treatment and have related time to reach key developmental stages to maternal bodyweight. In addition, we have measured non-invasively the metabolic activity of 150 IVF/ICSI embryos from a further 29 consecutive women who donated their surplus embryos to research, and have related the data retrospectively to their body mass index (BMI). PARTICIPANTS/MATERIALS, SETTING, METHODS In a clinical IVF setting, we compared oocyte morphology and developmental kinetics of supernumerary embryos collected from overweight and obese women, with a BMI in excess of 25 kg/m2 to those from women of healthy weight. A Primovision Time-Lapse system was used to measure developmental kinetics and the non-invasive COnsumption/RElese of glucose, pyruvate, amino acids and lactate were measured on spent droplets of culture medium. Total triglyceride levels within individual embryos were also determined. MAIN RESULTS AND THE ROLE OF CHANCE Human oocytes from women presenting for fertility treatment with a BMI exceeding 25 kg/m2 are smaller (R2 = −0.45; P = 0.001) and therefore less likely to complete development post-fertilization (P < 0.001). Those embryos that do develop reach the morula stage faster than embryos from women of a BMI < 25 kg/m2
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