Letter from Helen Leach Reed to John Muir, 1895 Feb 2.

74 Huntington Ave.,Boston, Feb. 2, \u2795.Mr. John Muir,Dear Sir:Your reputation as a naturalist, and the fact that I have just read with interest your Century communication on forest preservation induces me to trouble you with this letter.I own 160 acres of redwood land in Mendocino Co. about 10 miles east of Point Arena. I bought it in 1886, hoping at some time to sell it to some mill. I find it very hard, however, to get any satisfactory information from California, 1, as to whether redwood land is in general danger from people who would cut down trees not belonging to them; 2, as to whether such land has a prospective value large enough to warrant my paying taxes and holding it indefinitely. If you could refer me to any reliable person in San Francisco or Ukiah who could inform me about this I should be greatly obliged. Or I should be glad to hear of any pamphlets or maps published in California dealing with the redwood region. Begging that you will not answer unless perfectly convenient,Very truly,Helen Leach Ree

Age differences in mental health literacy

BACKGROUND: The community's knowledge and beliefs about mental health problems, their risk factors, treatments and sources of help may vary as a function of age. METHODS: Data were taken from an epidemiological survey conducted during 2003–2004 with a national clustered sample of Australian adults aged 18 years and over. Following the presentation of a vignette describing depression (n = 1001) or schizophrenia (n = 997), respondents were asked a series of questions relating to their knowledge and recognition of the disorder, beliefs about the helpfulness of treating professionals and medical, psychological and lifestyle treatments, and likely causes. RESULTS: Participant age was coded into five categories and cross-tabulated with mental health literacy variables. Comparisons between age groups revealed that although older adults (70+ years) were poorer than younger age groups at correctly recognising depression and schizophrenia, young adults (18–24 years) were more likely to misidentify schizophrenia as depression. Differences were also observed between younger and older age groups in terms of beliefs about the helpfulness of certain treating professionals and medical and lifestyle treatments for depression and schizophrenia, and older respondents were more likely to believe that schizophrenia could be caused by character weakness. CONCLUSION: Differences in mental health literacy across the adult lifespan suggest that more specific, age appropriate messages about mental health are required for younger and older age groups. The tendency for young adults to 'over-identify' depression signals the need for awareness campaigns to focus on differentiation between mental disorders

Activities of organic farmers succeeding in reducing lameness in dairy cows

Sixty-seven organic producers were among 189 dairy farmers completing the “Healthy Feet Project” in the UK. This aimed to reduce lameness in dairy herds by implementing existing knowledge. Participants received input at two levels: monitoring alone, or monitoring with extra support through a single veterinary advisory visit, annual visits from a trained non-veterinary facilitator and materials and contacts to encourage change. On average lameness on organic farms reduced by 12 percentage points over the three year period. On the farms achieving the greatest reduction,the most common changes were improvements to tracks and cubicle comfort, and more frequent footbathing or foot trimming. Practices to improve foot cleanliness, such as more frequent removal of slurry, were less often adopted. Further progress might be achieved by improvements of foot hygiene. Several farms with low lameness that reduced prevalence further improved their handling facilities and treated cows more promptly

Young people's views on the design of adrenaline auto-injectors: A qualitative study

Background: Young people’s compliance with carriage of adrenaline auto-injectors (AAI) may be as low as 41%, yet we lack research exploring their preferences regarding these devices. Objective: This qualitative study explored young people’s ideas about AAI design and features which may facilitate their carriage and use. Methods: Young people aged 13-18 years prescribed an AAI for severe allergic reaction were invited to participate in in-depth, semi-structured, face-to-face interviews about AAI design. Interviews were recorded, transcribed verbatim and analyzed using thematic content analysis. Results: From 23 interviews, seven major themes were identified: accessibility and carriage, comprehensibility of instructions, indication of correct administration, safety, speed of administration, visibility and identification and precise drug delivery. Young people made several suggestions for how AAIs may be adapted to improve carriage, including reduced size to enable pocket-carriage. Comprehensibility was thought to be enhanced by the use of pictographic instructions and audio-prompts to encourage prompt and accurate administration. Needle guards were seen as beneficial to reduce needle phobia, prevent accidental injury and provide reassurance that the device had been administered. Young people were conflicted between wanting a device which enabled discreet carriage, versus an AAI which was bold and clearly identifiable as a medical device in case of emergency. Conclusion: This study identified key AAI features important to young people, together with design issues deterring day-to-day carriage of AAIs and their emergency, time-pressured usage. We demonstrated considerable scope for AAI design modifications to improve young peoples’ perception of devices and facilitate their carriage and use

The Impact of Training on Women's Micro-Enterprise Development

Community/Rural/Urban Development,

Potential Impact of Antiviral Drug Use during Influenza Pandemic

Impact of different antiviral treatment strategies on hospitalizations during an influenza pandemic is evaluated

A longitudinal test of the predictions of the interpersonal-psychological theory of suicidal behaviour for passive and active suicidal ideation in a large community-based cohort

BACKGROUND The Interpersonal-Psychological Theory of Suicide (IPTS) aims to elucidate the key antecedents of suicide deaths. Limited research has tested the IPTS in a community setting, and very little longitudinal research has been conducted. The current study longitudinally tested the predictions of the IPTS for suicidal ideation in a large population-based sample. METHODS The PATH through Life study assesses three age cohorts (20's, 40's, 60's) every four years. Two interpersonal factors were estimated at the third wave of assessment: thwarted belongingness (TB) and perceived burdensomeness (PB). The roles of these factors in suicide ideation (active and passive) four years later were estimated using logistic regression models (n = 4545). RESULTS A one SD increase in TB was associated with increased odds of 37% for passive ideation and 24% for active ideation. For PB, odds were increased 2.5-fold for passive ideation and 2.4-fold for active ideation. A significant negative PB × TB interaction was found for passive but not active ideation. Effects were not consistent by age group or gender. LIMITATIONS Proxy measures were used to assess the constructs. The extended timeframe and low prevalence of suicidal ideation limited power to find effects within subgroups. CONCLUSIONS Although TB and PB were individually associated with suicidal thoughts, little evidence was found for the key predictions of the IPTS longitudinally. Further investigation of the dynamic interplay between interpersonal factors over time is needed.The study was supported by National Health and Medical Research Council (NHMRC) grants 973302, 179805, 350833, 157125 and Australian Research Council grant 130101705. PJB, ALC and HC are supported by NHMRC Fellowships 1083311, 1122544 and 1056964

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells

Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid organs is essential for limiting CLL progression and ultimately developing a cure. Experimental Design: We assessed the potency of cyclin-dependent kinase (CDK) inhibitor CR8, a roscovitine analog, to induce apoptosis in primary CLL from distinct prognostic subsets using flow cytometry–based assays. CLL cells were cultured in in vitro prosurvival and proproliferative conditions to mimic microenvironmental signals in the lymphoid organs, to elucidate the mechanism of action of CR8 in quiescent and proliferating CLL cells using flow cytometry, Western blotting, and quantitative real-time PCR. Results: CR8 was 100-fold more potent at inducing apoptosis in primary CLL cells than roscovitine, both in isolated culture and stromal-coculture conditions. Importantly, CR8 induced apoptosis in CD40-ligated CLL cells and preferentially targeted actively proliferating cells within these cultures. CR8 treatment induced downregulation of the antiapoptotic proteins Mcl-1 and XIAP, through inhibition of RNA polymerase II, and inhibition of NF-κB signaling at the transcriptional level and through inhibition of the inhibitor of IκB kinase (IKK) complex, resulting in stabilization of IκBα expression. Conclusions: CR8 is a potent CDK inhibitor that subverts pivotal prosurvival and proproliferative signals present in the tumor microenvironment of CLL patient lymphoid organs. Our data support the clinical development of selective CDK inhibitors as novel therapies for CLL

Commentary:considerations for using the 'Trials within Cohorts' design in a clinical trial of an investigational medicinal product

Abstract Background The ‘trials within cohorts’ (TwiC) design is a pragmatic approach to randomised trials in which trial participants are randomly selected from an existing cohort. The design has multiple potential benefits, including the option of conducting multiple trials within the same cohort. Main text To date, the TwiC design methodology been used in numerous clinical settings but has never been applied to a clinical trial of an investigational medicinal product (CTIMP). We have recently secured the necessary approvals to undertake the first CTIMP using the TwiC design. In this paper, we describe some of the considerations and modifications required to ensure such a trial is compliant with Good Clinical Practice and international clinical trials regulations. We advocate using a two-stage consent process and using the consent stages to explicitly differentiate between trial participants and cohort participants who are providing control data. This distinction ensured compliance but had consequences with respect to costings, recruitment and the trial assessment schedule. Conclusion We have demonstrated that it is possible to secure ethical and regulatory approval for a CTIMP TwiC. By including certain considerations at the trial design stage, we believe this pragmatic and efficient methodology could be utilised in other CTIMPs in future