Lateral error compensation for stitching-free measurement with focus variation microscopy

This paper proposes a practical methodology to quantify and compensate lateral errors for focus variation microscopy measurements without stitching. The main advantages of this new methodology are its fast and simple implementation using any uncalibrated artefact. The methodology is applied by performing measurements with multiple image fields with and without stitching on an uncalibrated artefact and using the stitched measurements as reference. To quantify the lateral errors, the determination of their geometrical components is carried out through kinematic modelling. With the quantified errors, compensation can be applied for lateral measurements without stitching. Over the entire 200mm lateral range, the lateral errors without stitching and without compensation can reach up to 180 mu m. With the proposed error compensation methodology, the lateral errors have been reduced to around 15 mu m. The proposed methodology can be applied to any Cartesian-based optical measuring instrument

Reproducibility of the lung anatomy under Active Breathing Coordinator control: Dosimetric consequences for scanned proton treatments.

Purpose/Objective The treatment of moving targets with scanning proton beams is challenging. By controlling lung volumes, Active Breathing Control (ABC) assists breath-holding for motion mitigation. The delivery of proton treatment fractions often exceeds feasible breath-hold durations, requiring high breath-hold reproducibility. Therefore, we investigated dosimetric consequences of anatomical reproducibility uncertainties in the lung under ABC, evaluating robustness of scanned proton treatments during breath-hold. Material/Methods T1-weighted MRIs of five volunteers were acquired during ABC, simulating image acquisition during four subsequent breath-holds within one treatment fraction. Deformation vector fields obtained from these MRIs were used to deform 95% inspiration phase CTs of 3 randomly selected non-small-cell lung cancer patients (Figure 1). Per patient, an intensity-modulated proton plan was recalculated on the 3 deformed CTs, to assess the dosimetric influence of anatomical breath-hold inconsistencies. Results Dosimetric consequences were negligible for patient 1 and 2 (Figure 1). Patient 3 showed a decreased volume (95.2%) receiving 95% of the prescribed dose for one deformed CT. The volume receiving 105% of the prescribed dose increased from 0.0% to 9.9%. Furthermore, the heart volume receiving 5 Gy varied by 2.3%. Figure 2 shows dose volume histograms for all relevant structures in patient 3. Conclusion Based on the studied patients, our findings suggest that variations in breath-hold have limited effect on the dose distribution for most lung patients. However, for one patient, a significant decrease in target coverage was found for one of the deformed CTs. Therefore, further investigation of dosimetric consequences from intra-fractional breath-hold uncertainties in the lung under ABC is needed

Inflationary perturbations from a potential with a step

We use a numerical code to compute the density perturbations generated during an inflationary epoch which includes a spontaneous symmetry breaking phase transition. A sharp step in the inflaton potential generates $k$ dependent oscillations in the spectrum of primordial density perturbations. The amplitude and extent in wavenumber of these oscillations depends on both the magnitude and gradient of the step in the inflaton potential. We show that observations of the cosmic microwave background anisotropy place strong constraints on the step parameters.Comment: 6 pages, Revtex - v2. reference adde

Electrocatalytic Site Activity Enhancement via Orbital Overlap in A ₂MnRuO ₇(A = Dy ³⁺, Ho ³⁺, and Er ³⁺) Pyrochlore Nanostructures

Oxygen electrocatalysis at transition metal oxides is one of the key challenges underpinning electrochemical energy conversion systems, involving a delicate interplay of the bulk electronic structure and surface coordination of the active sites. In this work, we investigate for the first time the structure-activity relationship of A2RuMnO7 (A = Dy3+, Ho3+, and Er3+) nanoparticles, demonstrating how orbital mixing of Ru, Mn, and O promotes high density of states at the appropriate energy range for oxygen electrocatalysis. The bulk structure and surface composition of these multicomponent pyrochlores are investigated by high-resolution transmission electron microscopy, X-ray diffraction, X-ray absorption spectroscopy, X-ray emission spectroscopy (XES), and X-ray photoemission spectroscopy (XPS). The materials exhibit high phase purity (cubic fcc with a space group Fd3\uaf m) in which variations in M-O bonds length are less than 1% upon replacing the A-site lanthanide. XES and XPS show that the mean oxidation state at the Mn-site as well as the nanoparticle surface composition was slightly affected by the lanthanide. The pyrochlore nanoparticles are significantly more active than the binary RuO2 and MnO2 toward the 4-electron oxygen reduction reaction in alkaline solutions. Interestingly, normalization of kinetic parameters by the number density of electroactive sites concludes that Dy2RuMnO7 shows twice higher activity than benchmark materials such as LaMnO3. Analysis of the electrochemical profiles supported by density functional theory calculations reveals that the origin of the enhanced catalytic activity is linked to the mixing of Ru and Mn d-orbitals and O p-orbitals at the conduction band which strongly overlap with the formal redox energy of O2 in solution. The activity enhancement strongly manifests in the case of Dy2RuMnO7 where the Ru/Mn ratio is closer to 1 in comparison with the Ho3+ and Er3+ analogs. These electronic effects are discussed in the context of the Gerischer formalism for electron transfer at the semiconductor/electrolyte junctions

Single-field inflation constraints from CMB and SDSS data

We present constraints on canonical single-field inflation derived from WMAP five year, ACBAR, QUAD, BICEP data combined with the halo power spectrum from SDSS LRG7. Models with a non-scale-invariant spectrum and a red tilt n_s < 1 are now preferred over the Harrison-Zel'dovich model (n_s = 1, tensor-to-scalar ratio r = 0) at high significance. Assuming no running of the spectral indices, we derive constraints on the parameters (n_s, r) and compare our results with the predictions of simple inflationary models. The marginalised credible intervals read n_s = 0.962^{+0.028}_{-0.026} and r < 0.17 (at 95% confidence level). Interestingly, the 68% c.l. contours favour mainly models with a convex potential in the observable region, but the quadratic potential model remains inside the 95% c.l. contours. We demonstrate that these results are robust to changes in the datasets considered and in the theoretical assumptions made. We then consider a non-vanishing running of the spectral indices by employing different methods, non-parametric but approximate, or parametric but exact. With our combination of CMB and LSS data, running models are preferred over power-law models only by a Delta chi^2 ~ 5.8, allowing inflationary stages producing a sizable negative running -0.063^{+0.061}_{-0.049} and larger tensor-scalar ratio r < 0.33 at the 95% c.l. This requires large values of the third derivative of the inflaton potential within the observable range. We derive bounds on this derivative under the assumption that the inflaton potential can be approximated as a third order polynomial within the observable range.Comment: 32 pages, 7 figures. v2: additional references, some typos corrected, passed to JCAP style. v3: minor changes, matches published versio