A single locus determines praziquantel response in Schistosoma mansoni

We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information

BALB/c_LE_Trichrome_images

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 19/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

C57BL/6_LE_H&E_images 2/2

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 24/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

C57BL/6_control_H&E_images

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 1/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

C57BL/6_EG_Trichrome_images

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 18/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

BALB/c_OR_Trichrome_images 1/2

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 20/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

C57BL/6_OR_Trichrome_images 1/2

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 12/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

BALB/c_EG_H&E_images

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 14/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

C57BL/6_EG_Trichrome_images 1/2

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 10/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt

C57BL/6_OR_Trichrome_images 2/2

<p>The present dataset contains all histopathology images used to quantify fibrotic and granuloma area in livers of uninfected control mice. These data are presented in the manuscript entitled "<strong>Contribution of parasite and host genotype to immunopathology of schistosome infections" </strong>(dataset # 26/27)</p><p>Each file name is in the following format: (Project ID)_(Sampe_ID)_(Slide_number)_(Species)_(Slide_per_sample).czi</p> <p>Example: 22_0670_3C_19_MUS_1.czi </p> <p>Project = 22_0670</p> <p>Sample = 3C</p> <p>Slide number = 19</p> <p>Species = MUS</p> <p>Slide number for this sample: 3</p&gt