Inquérito sorológico para doença de Chagas em áreas rurais de Manaus, Coari e Tefé na Amazônia Ocidental

Submitted by Sandra Infurna ([email protected]) on 2017-06-13T16:28:06Z No. of bitstreams: 1 josecoura_etal_IOC_2011.pdf: 713583 bytes, checksum: 4b85288d95ee4f1ee962b5f383123892 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2017-06-13T16:43:07Z (GMT) No. of bitstreams: 1 josecoura_etal_IOC_2011.pdf: 713583 bytes, checksum: 4b85288d95ee4f1ee962b5f383123892 (MD5)Made available in DSpace on 2017-06-13T16:43:07Z (GMT). No. of bitstreams: 1 josecoura_etal_IOC_2011.pdf: 713583 bytes, checksum: 4b85288d95ee4f1ee962b5f383123892 (MD5) Previous issue date: 2011Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Escola Superior de Ciências da Saúde. Manaus, AM, Brasil.Fundação de Medicina Tropical Heitor Vieira Dourado. Gerência de Entolomogia e Leishmaniose. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Medicina. Manaus, AM, BrasilUniversidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Escola Superior de Ciências da Saúde. Manaus, AM, Brasil.Universidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, Brasil / Universidade Federal do Amazonas. Faculdade de Medicina. Manaus, AM, BrasilInstituto de Medicina Tropical de São Paulo. Laboratório de Doenças Parasitárias. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Escola Superior de Ciências da Saúde. Manaus, AM, Brasil./ Fundação de Medicina Tropical Heitor Vieira Dourado. Gerência de Entolomogia e Leishmaniose. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-graduação em Medicina Tropical. Escola Superior de Ciências da Saúde. Manaus, AM, Brasil./ Fundação de Medicina Tropical Heitor Vieira Dourado. Gerência de Entolomogia e Leishmaniose. Manaus, AM, Brasil / Universidade Nilton Lins. Departamento de Biologia. Manaus, AM, Brasil.Introduction: Deforestation, uncontrolled forest, human population migration from endemic areas, and the large number of reservoirs and wild vectors naturally infected by Trypanosoma cruzi promote the endemicity of Chagas disease in the Amazon region. Methods: We conducted an initial serological survey (ELISA) in a sample of 1,263 persons; 1,095 (86.7%) were natives of the state of Amazonas, 666 (52.7%) were male, and 948 (75.1%) were over 20 years old. Serum samples that were found to be reactive, indeterminate, or inconclusive by indirect immunofluorescence (IFI) or positive with low titer by IFA were tested by Western blot (WB). Serologically confirmed patients (WB) were evaluated in terms of epidemiological, clinical, ECG, and echocardiography characteristics. Results: Fifteen patients had serologically confirmed T. cruzi infection, and 12 of them were autochthonous to the state of Amazonas, for an overall seroprevalence of 1.2% and 0.9% for the state of Amazonas. Five of the 15 cases were males, and the average age was 47 years old; most were farmers with low education. One patient who was not autochthonous, having originated from Alagoas, showed right bundle branch block, bundle branch block, and anterosuperior left ventricular systolic dysfunction with an ejection fraction of 54%. Conclusions: The results of this study ratify the importance of monitoring CD cases in Amazonia, particularly in the state of Amazonas

Serological survey for Chagas disease in the rural areas of Manaus, Coari, and Tefé in the Western Brazilian Amazon

INTRODUCTION: Deforestation, uncontrolled forest, human population migration from endemic areas, and the large number of reservoirs and wild vectors naturally infected by Trypanosoma cruzi promote the endemicity of Chagas disease in the Amazon region. METHODS: We conducted an initial serological survey (ELISA) in a sample of 1,263 persons; 1,095 (86.7%) were natives of the State of Amazonas, 666 (52.7%) were male, and 948 (75.1%) were over 20 years old. Serum samples that were found to be reactive, indeterminate, or inconclusive by indirect immunofluorescence (IFI) or positive with low titer by IFA were tested by Western blot (WB). Serologically confirmed patients (WB) were evaluated in terms of epidemiological, clinical, ECG, and echocardiography characteristics. RESULTS: Fifteen patients had serologically confirmed T. cruzi infection, and 12 of them were autochthonous to the state of Amazonas, for an overall seroprevalence of 1.2% and 0.9% for the state of Amazonas. Five of the 15 cases were males, and the average age was 47 years old; most were farmers with low education. One patient who was not autochthonous, having originated from Alagoas, showed right bundle branch block, bundle branch block, and anterosuperior left ventricular systolic dysfunction with an ejection fraction of 54%. CONCLUSIONS: The results of this study ratify the importance of monitoring CD cases in Amazonia, particularly in the state of Amazonas